significantly lower – Page 20 – Communicable Diseases Research

Specific Antibody and the T-Cell Response Elicited by BNT162b2 Boosting After Two ChAdOx1 nCoV-19 in Common Variable Immunodeficiency

공통 가변성 면역 결핍증에서 2개의 ChAdOx1 nCoV-19 후 BNT162b2 부스팅에 의해 유도된 특정 항체 및 T-세포 반응

Article

Published on 2022-06-172022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술,

Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response

중증 급성 호흡기 증후군 코로나바이러스 2 환자에서 전염증성 지질 매개체 및 전문 분해 분자의 혈청 수준이 증가하고 적응 면역 반응의 마커와 상관 관계가 있습니다

Article

Published on 2022-06-152022-09-11
Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Anti-inflammatory Anti-nucleocapsid Anti-spike anti-spike antibody assays binding bioactive lipids Clinical outcome collected Concentration Control coronavirus coronavirus 2 died female hospital identify immune immune response Increased innate response Inpatient Level linoleic acid Lipid lipids male mediator molecule Omega pandemic pathogenic inflammation Pathways Patient patients positive correlation processed proinflammatory quantification Quantitative respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients serum Serum level serum levels severe acute respiratory syndrome Coronavirus Sex significantly higher significantly lower specialized proresolving molecules. symptomatic SARS-CoV-2 infection transition
[DOI] 10.1093/infdis/jiab632 PMC 바로가기 [Article Type] Article

Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination

기존 항체 수준은 단일 용량의 BBV152 백신 접종 후 항체 역가와 음의 상관관계가 있습니다

Article

Published on 2022-06-152022-09-11
Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Clinical Severity of SARS-CoV-2 Omicron Variant Compared with Delta among Hospitalized COVID-19 Patients in Belgium during Autumn and Winter Season 2021-2022

2021-2022년 가을 및 겨울 시즌 동안 벨기에의 입원한 COVID-19 환자 중 델타와 비교한 SARS-CoV-2 오미크론 변이의 임상 심각도

Multicenter Study

Published on 2022-06-142022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종,

[키워드] 95% CI added adjusted Admission Analysis Belgium clinical cohort study Combination Comorbidities confounder COVID-19 COVID-19 pathogenesis COVID-19 patient Delta delta variant demographics genomic genomic data Genomic surveillance hospital Hospital mortality hospitalized patient hospitalized patients ICU ICU admission in-hospital mortality intensive care intensive care unit multifactorial multivariable logistic regression Multivariable logistic regression analysis National not significantly different omicron Omicron variant recognize retrospective risk SARS-CoV-2 SARS-CoV-2 variant season severe COVID-19 severity significantly lower study population Surveillance the SARS-CoV-2 vaccination Vaccination Status variant were infected Winter
[DOI] 10.3390/v14061297 PMC 바로가기 [Article Type] Multicenter Study

A cross-sectional multicenter linkage study of hospital admissions and mortality due to methanol poisoning in Iranian adults during the COVID-19 pandemic

Research

Published on 2022-06-132022-10-05
Journal: Scientific Reports [Category] 치료법,

An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model

ADAM17 중화 항체는 COVID-19 마우스 모델에서 바이러스 부담을 증가시키면서 염증과 사망률을 감소시킵니다

Article

Published on 2022-06-102022-09-12
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] ACE2 ADAM17 ADAM19 adverse outcome Alter angiotensin anti-viral role antibody appear blockade blocked burden Cell cell entry receptor cellular activation cleave COVID-19 COVID-19 pathogenesis COVID-19 patients Critical ectodomain Increasing Inflammation Inflammatory inflammatory cascade K18-hACE2 less lung Lung pathology lung; metalloproteinase mice Model monoclonal antibody mouse mouse model pathway Proinflammatory cytokine promote protease Proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 viruses significantly increased significantly lower therapeutic TNF-α Transgenic mouse transmembrane viral burden virus while
[DOI] 10.3389/fimmu.2022.918881 PMC 바로가기 [Article Type] Article

Dynamic blood oxygen indices in mechanically ventilated COVID-19 patients with acute hypoxic respiratory failure: A cohort study

Observational Study

Published on 2022-06-102022-10-04
Journal: PLoS ONE [Category] COVID19(2023년), SARS, 임상,

[키워드] Admission adult COVID-19 patient adult COVID-19 patients age AHRF analysed averaged baseline characteristics Blood blood oxygen BMI changes in Clinical outcome clinical outcomes clinical variable cohort of patient cohort study collected COVID-19 COVID-19 patient COVID-19 patients dynamic evaluate evaluated exhibited exploratory study hallmark help homogenous hypoxaemia hypoxic hypoxic respiratory failure IMPROVE intensive care Invasive mechanical ventilation IQR kPa less majority mean difference mechanical ventilation mechanically ventilated men morbidity and mortality non-survivor Non-survivors Observational cohort study offer outcome oxygen PaO2 PaO2/FiO2 ratio Patient performed retrospective Severe COVID-19 pneumonia significantly higher significantly lower supplementary oxygen survival survivor therapy understanding unique while
[DOI] 10.1371/journal.pone.0269471 PMC 바로가기 [Article Type] Observational Study

Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccines

Clinical and Translational Report

Published on 2022-06-092022-10-04
Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘,

[키워드] Abstract Affect Analysis Animal experiment antibody antibody cross-reactivity antibody response against association B.1.617.2 Booster vaccine breadth China circulating clinical evidence clinical observation Cohort Commission conducted confounders Context cost-efficient strategy COVID-19 vaccination COVID-19 vaccine Department development elicit Evidence finding foundation funding Health care worker healthcare worker Heterologous heterologous prime-boost heterologous vaccination heterologous vaccine homologous homologous or heterologous immune responses immunological analysis inactivated Influenza Innovation International Laboratory test mechanism Multivariable regression natural Neutralization antibody neutralization titer Neutralizing Neutralizing activity physician PNA Program protective immunity Pseudovirus neutralization assay recipient SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Science Serum Neutralization Shenzhen shown significantly lower subsequent suggested technology the United State the vaccine vaccination vaccination schedule Vaccine Vaccines variant variants veteran Virus neutralization Wuhan-Hu-1
[DOI] 10.1016/j.medj.2022.05.003 PMC 바로가기 [Article Type] Clinical and Translational Report

Covid-19 vaccine immunogenicity in people living with HIV-1

HIV-1에 감염된 사람들의 코비드-19 백신 면역원성

Article

Published on 2022-06-092022-09-12
Journal: Vaccine [Category] MERS, 임상, 진단,

[키워드] age Analysis Anti-RBD IgG antibody baseline booster dose CD4 CD4 count CD4 counts clinical trial control group COVID-19 vaccine Covid-19 Vaccine immunogenicity Covid-19 Vaccines in Immunocompromised Patients Covid-19 Vaccines in people living with HIV effective Efficacy ELISA evaluated first dose General population Health care worker HIV HIV clinics HIV-1 HIV-positive individual HIV-positive individuals Hypothesis IgG response Immunocompromised patients Immunosuppression Increasing individual lowest Montreal mRNA mRNA vaccine mRNA vaccine immunogenicity in people living with HIV. mRNA Vaccines in people living with HIV naïve negative control participant receiving recruited response SARS CoV-2 second dose significantly lower stratified Support Vaccine vaccine immunogenicity Vaccine immunogenicity HIV was used were measured with HIV
[DOI] 10.1016/j.vaccine.2022.04.090 PMC 바로가기 [Article Type] Article

Favipiravir, camostat, and ciclesonide combination therapy in patients with moderate COVID-19 pneumonia with/without oxygen therapy: An open-label, single-center phase 3 randomized clinical trial

Research article

Published on 2022-06-032022-10-05
Journal: EClinicalMedicine [Category] 신약개발, 임상, 치료제,

[키워드] 95% CI Admission Adverse AMED assigned calculated camostat Characteristics Ciclesonide clinical Clinical finding Clinical management Combination combination therapy comparable COVID-19 COVID-19 infection deaths decrease development discharge Effectiveness enrolled evaluated event Favipiravir finding funding group groups healthcare worker hospital discharge rate Hospital stay Hospitalization Hospitalized Japan Japanese lack less limitation median time Ministry of Health monotherapy no significant difference number Open-label oxygen participant Patient patients patients with moderate Phase 3 phase 3 study Pneumonia positive Primary outcome randomized clinical trial Randomized controlled trial Randomly Registered registry Research SARS-CoV-2 Severe COVID-19 Infection significantly higher significantly lower single-center statistically supported therapy Treatment vaccination Version Welfare
[DOI] 10.1016/j.eclinm.2022.101484 [Article Type] Research article