Effects of the Coronavirus Disease 2019 Pandemic on Human Immunodeficiency Virus Services: Findings from 11 Sub-Saharan African Countries코로나바이러스 질병 2019 팬데믹이 인간 면역결핍 바이러스 서비스에 미치는 영향: 사하라 사막 이남의 11개 아프리카 국가의 결과Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 치료제, [키워드] Africa African analyzed Antiretroviral therapy ART change conducted coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 crisis COVID-19 pandemic declined declines declining decrease delivery of healthcare. Effect examined finding Health health facilities Health services healthcare HIV HIV testing Human Human immunodeficiency virus immunodeficiency virus increase Increases initial initiated Measures New no decrease pandemic rebound receiving Resilience SARS-CoV-2 sub-Saharan Africa tested Viral load VL testing [DOI] 10.1093/cid/ciab951 PMC 바로가기 [Article Type] Article
A simple model of COVID-19 explains disease severity and the effect of treatments Research Published on 2022-08-202022-10-05 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법, 치료제, [키워드] Administered administration Analysis Antiviral Asymptomatic Cell Clinical finding Clinical outcome condition COVID-19 damage-associated molecular pattern damaged cell DAMP DAMPs disease severity dysregulated effect of treatment effort explain expressing hyperinflammation hypoxia infected cell Infection Inflammation interferon response lack less likelihood mathematical molecular natural killer cell Neutrophil extracellular traps PAMP PAMPs pathogen pathogen-associated molecular pattern pathogenesis of COVID-19 producing SARS-COV-2 infection severe COVID-19 Treatment Treatment strategies Viral load [DOI] 10.1038/s41598-022-18244-2 [Article Type] Research
A comprehensive modelling approach to estimate the transmissibility of coronavirus and its variants from infected subjects in indoor environments실내 환경에서 감염된 대상의 코로나바이러스 및 변이체의 전파 가능성을 추정하기 위한 포괄적인 모델링 접근 방식Article Published on 2022-08-192022-09-11 Journal: Scientific Reports [Category] SARS, 변종, [키워드] addition approach being coronavirus coronavirus variant COVID-19 infections droplet droplets fluctuation fluctuations increase individual infect Infection lung Lungs methodology Multiple Particle Poisson model Poisson models Probability quantified reducing risk Risk assessment risk of COVID-19 risk of infection RNA statistical subject susceptible Transmissibility variant Viral load viral loads virion [DOI] 10.1038/s41598-022-17693-z PMC 바로가기 [Article Type] Article
Infections with the SARS-CoV-2 Delta variant exhibit fourfold increased viral loads in the upper airways compared to Alpha or non-variants of concernSARS-CoV-2 Delta 변이체 감염은 우려되는 알파 또는 비 변이체에 비해 상기도에서 4배 증가된 바이러스 부하를 나타냅니다.Article Published on 2022-08-172022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age all age group all age groups Alpha Alpha variant B.1.1.7 B.1.617.2 coronavirus Delta delta variant dominant Evidence evidenced genomic Genomic surveillance group groups in viral no difference Older age other variants reported respiratory sample Respiratory samples Sample size SARS-CoV-2 severe acute respiratory syndrome Coronavirus Sex significantly lower suggested Surveillance the SARS-CoV-2 Transmissibility upper airway vaccination variant variants Viral load viral loads Wuhan strain [DOI] 10.1038/s41598-022-18279-5 PMC 바로가기 [Article Type] Article
Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion proteinRBD-뉴클레오캡시드 융합단백질을 이용한 관심대상 야생형 및 SARS-CoV-2 변이체에 대한 중화항체 비의존성 면역 촉진Article Published on 2022-08-172022-09-11 Journal: Nature Communications [Category] SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] ablated angiotensin antibody Antigen B cell B cells Blood CD4 CD8 chimeric circumvent Clinical outcome convertase COVID-19 convalescent donors COVID-19 vaccine COVID-19 vaccines Delta Depletion detectable effector T cell effector T cells elicit elicited experimental model experimental models fusion protein generate hamster IFN-γ Immune escape Immunity immunization IMPROVE inactivated indicated individual Infection infection with SARS-CoV-2 less lethality levels of antibody Lung inflammation mice NAbs Neutralizing Neutralizing antibodies neutralizing antibody nucleocapsid omicron promote promotion PROTECT Protein protocol protocols RBD RBD protein Receptor binding domain reduction robust SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 vaccine SARS-CoV-2 variant shown spike Spin T cell T cells transferred vaccination Vaccine variants variants of concern Viral Viral load virus wild type wild-type [DOI] 10.1038/s41467-022-32547-y PMC 바로가기 [Article Type] Article
Ultrasensitive SARS-CoV-2 diagnosis by CRISPR-based screen-printed carbon electrodeCRISPR 기반 스크린 인쇄 탄소 전극으로 초고감도 SARS-CoV-2 진단Article Published on 2022-08-152022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] carbon CeO(2) nanorods cleavage COVID-19 CRISPR CRISPR/Cas12a detection Detection sensitivity detection system Diagnosis diagnosis of SARS-CoV-2 reporter required SARS-CoV-2 SARS-CoV-2 detection Screen Screen-printed carbon electrode. ssDNA Viral load [DOI] 10.1016/j.aca.2022.340120 PMC 바로가기 [Article Type] Article
A fast and sensitive absolute quantification assay for the detection of SARS-CoV-2 peptides using parallel reaction monitoring mass spectrometry병렬 반응 모니터링 질량 분석을 사용한 SARS-CoV-2 펩타이드 검출을 위한 빠르고 민감한 절대 정량 분석Article Published on 2022-08-152022-09-11 Journal: Journal of proteomics [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] Absolute quantification Clinical diagnosis clinics COVID-19 Ct values Early detection enrichment heat heat-inactivated high resolution high viral load investigated mass mass spectrometry Nasopharyngeal swab nasopharyngeal swab sample Orbitrap pandemic Patient peptide peptides positive positive patient positive patients PRM Protein quantification required RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid SARS-CoV-2 peptide sensitivity speed Surveillance swab samples the disease Viral load Viral protein Viral proteins [DOI] 10.1016/j.jprot.2022.104664 PMC 바로가기 [Article Type] Article
Improved SARS-CoV-2 sequencing surveillance allows the identification of new variants and signatures in infected patients향상된 SARS-CoV-2 시퀀싱 감시를 통해 감염된 환자의 새로운 변이체 및 서명 식별 가능Article Published on 2022-08-122022-09-11 Journal: Genome Medicine [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis applied approach Automation B.1 Campania cohorts of patients collected coronavirus correlated COVID-19 pandemic Disease progression Efficacy gain-of-function gene expression signature generate genetic variability Genome genomic Genomic surveillance highest Host host gene expression identify immune protection Improved increase in infected patient Infection Italy lab limit Metadata MONITOR Mutation nasal swab nasal swabs pandemic Patient premises principle producing prognostic biomarker Prognostic biomarkers reconstructed respiratory epithelium reverse transcribed RNA Sample SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-COV-2 infection SARS-CoV-2 sequencing scrutiny sequence sequenced sequences severe acute respiratory syndrome Coronavirus Spread Surveillance Transcriptome Treatment upper respiratory Vaccination strategies Vaccination strategy Variability variant variants of concern viral genome Viral genome sequencing viral genomes Viral load viral variant virus VoC was performed [DOI] 10.1186/s13073-022-01098-8 PMC 바로가기 [Article Type] Article
A disturbed balance between blood complement protective factors (FH, ApoE) and common pathway effectors (C5a, TCC) in acute COVID-19 and during convalesce Research Published on 2022-08-112022-10-05 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료법, [키워드] activate Activation acute COVID-19 affected Blood C-reactive protein C5a Cluster collected complement Complement activation complex conditions convalescent plasma treatment correlated COVID-19 COVID-19 patients CRP death Deep venous thrombosis demonstrated DVT effector electronic medical records element elevated event HMGB1 homeostasis IgA IgG IgM IL-6 immune response immune system immunological Immunological response incidence Increased Infection Inflammatory response investigated knowledge marker Mortality Necrosis non-specific pathway Patient patients hospitalized PCR-confirmed diagnosis protective factor RAGE remained SARS-COV-2 infection SARS-CoV-2 spike protein shown tissue Treatment viral burden Viral load was collected were assessed [DOI] 10.1038/s41598-022-17011-7 [Article Type] Research
Wastewater and marine bioindicators surveillance to anticipate COVID-19 prevalence and to explore SARS-CoV-2 diversity by next generation sequencing: One-year studyCOVID-19 유행을 예측하고 차세대 염기서열 분석을 통해 SARS-CoV-2 다양성을 탐색하기 위한 폐수 및 해양 생물지표 감시: 1년 연구Article Published on 2022-08-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료기술, [키워드] a minor Analysis Biomarker Combination COVID-19 detect discharge eliminated Epidemiology Evolution Final Forecasting health system mathematical minor outbreak pandemic plant predict Predictive model Prevalence provided quantification RNA sampling SARS-CoV-2 SARS-CoV-2 sequencing SARS-CoV-2 surveillance Seawater Spain stochastic stochastic SIR model Surveillance the marine treated Treatment Viral Viral load virus virus variants was used wastewater Wastewater-based epidemiology water [DOI] 10.1016/j.scitotenv.2022.155140 PMC 바로가기 [Article Type] Article