Reconciling model predictions with low reported cases of COVID-19 in Sub-Saharan Africa: insights from MadagascarResearch Article Published on 2020-10-052022-10-31 Journal: Global Health Action [Category] COVID-19, MERS, [키워드] age-structured contacts Analysis clinical trial Combination conditions Conventional country COVID-19 COVID-19 case COVID-19 epidemic Epidemic Epidemiology explained fatality Final Government Health health systems healthcare implementation implication incidence incidence of COVID-19 infect Infectious disease modelling Intervention lack madagascar majority Non-pharmaceutical interventions NPI NPIs Outbreak response predict public health threat Region reported risk SSA sub-Saharan Africa the epidemic Therapies Vaccine [DOI] 10.1080/16549716.2020.1816044 PMC 바로가기 [Article Type] Research Article
The Current Status of COVID-19 VaccinesGenome Editing Published on 2020-10-022022-10-31 Journal: Frontiers in Genome Editing [Category] COVID-19, [키워드] accelerated Adenovirus approach candidate clinical trial COVID-19 COVID-19 pandemic COVID-19 patients current demonstrated DNA DNA vaccines healthy volunteers immune response immune responses inactivated inactivated viruses include individual live-attenuated mRNA mRNA-based vaccine mRNA-based vaccines neutralizing antibody participant peptides phase phase III trial plasmids preclinical study preliminary finding Protein subunit reduced viral load robust rodent SARS-CoV-2 self-amplifying RNA status Study protocol Tolerability Vaccines viral vector-based viral vectors [DOI] 10.3389/fgeed.2020.579297 PMC 바로가기 [Article Type] Genome Editing
Progress and Pitfalls in the Quest for Effective SARS-CoV-2 (COVID-19) VaccinesImmunology Published on 2020-10-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adverse effects adverse events of special interest (AESI) antibody antibody dependent enhancement (ADE) approach approaches Bacillus Calmette-Guérin (BCG) candidate candidate vaccine Cell mediated immunity clinical trial Coalition for Epidemic Preparedness Innovations (CEPI) COVID-19 Critical effective Efficacy effort Ensuring globe groups Human immune immune response immunize immunogenic impacts in healthy individual Innate immunity knowledge likelihood Neutralizing antibodies occur pandemic Progress PROTECT quest required Safe safety profile SARS-CoV-2 SARS-CoV-2 vaccine shown Spike protein stimulate Surveillance T cell response Trial Vaccine Vaccine development virus [DOI] 10.3389/fimmu.2020.579250 PMC 바로가기 [Article Type] Immunology
Health Communication and Decision Making about Vaccine Clinical Trials during a Pandemic팬데믹 기간 동안 백신 임상 시험에 대한 건강 커뮤니케이션 및 의사 결정Article Published on 2020-10-022022-09-11 Journal: Journal of health communication [Category] 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach cause clinical clinical trial clinical trials communication coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine Decision making Decision-making disinformation effective ENhance health information help highlight IMPROVE literacy misinformation pandemic Participation Patient PROTECT raised reduce resource respiratory Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus Vaccine Vaccine hesitancy virus [DOI] 10.1080/10810730.2020.1864520 PMC 바로가기 [Article Type] Article
A multi-center, randomized controlled trial by the Integrative Management in Japan for Epidemic Disease (IMJEDI study-RCT) on the use of Kampo medicine, kakkonto with shosaikotokakikyosekko, in mild-to-moderate COVID-19 patients for symptomatic relief and prevention of severe stage: a structured summary of a study protocol for a randomized controlled trialLetter Published on 2020-10-022022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 Ability to communicate acute respiratory syndrome addition administration age Analysis antipyretics Arm Blinding calculated clinical clinical trial Combination common cold-like symptom control group coronavirus cough COVID-19 COVID-19 patient criteria decrease defined Dementia difficulty dissemination effective Efficacy element exclusion criteria fatigue female Fever Follow-up group H1N1 influenza hospitals Hypothesis IMPROVE in both group include Inclusion Infection Inpatient Japan Japanese Kampo Kampo medicines lactating less malaise Medicine Mild-to-moderate number objective occurred outcome Outpatient parallel-group participant Patient patients positive Prevention for severe stage previous study protocol Psychiatric random Randomized Randomized controlled trial receive recruited registry required Research Sample size SARS-CoV-2 Severe infection Severity of disease Shortness of breath significance level significantly sputum Stage steroid Study protocol survival survival curve Symptom Symptom relief symptomatic temperature the Kaplan-Meier method the log-rank test the median the primary endpoint the SARS-CoV-2 to define treated Treatment Two-arm website [DOI] 10.1186/s13063-020-04746-9 PMC 바로가기 [Article Type] Letter
Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID)Research article Published on 2020-10-012022-10-05 Journal: Engineering [Category] 임상, [키워드] 2019 novel coronavirus 2019-nCoV addition all-cause mortality carried categories Chinese clinical Clinical outcome clinical pharmacology Clinical symptoms clinical trial clinical trials collected conducted Consensus core Core outcome set coronavirus disease COVID-19 Critical DelPhi develop events Evidence FiO2 FIVE heterogeneity Hospital stay include intervention effect less measure mechanical ventilation Mild negativity outbreak outcome oxygen protocol Pulmonary function Registered rehabilitation Research resources RT-PCR searched selected Seven Standardization TCM Trial Version website [DOI] 10.1016/j.eng.2020.03.002 [Article Type] Research article
Selecting appropriate endpoints for assessing treatment effects in comparative clinical studies for COVID-19COVID-19에 대한 비교 임상 연구에서 치료 효과를 평가하기 위한 적절한 종료점 선택Article Published on 2020-10-012022-09-11 Journal: Contemporary clinical trials [Category] SARS, 임상, 치료법, [키워드] Analysis appear approach circumvent clinical study clinical trial COVID-19 death duration of hospitalization effective Efficacy Efficacy and safety Endpoint evaluate events example Follow-up hospital Hospitalization ICU lead outcome oxygen Patient receipt reconstructed standard care supplemental oxygen survival survival analysis survival time Treatment treatment effect treatment for COVID-19 treatment group [DOI] 10.1016/j.cct.2020.106145 PMC 바로가기 [Article Type] Article
Intention to participate in a COVID-19 vaccine clinical trial and to get vaccinated against COVID-19 in France during the pandemicResearch article Published on 2020-10-012022-10-05 Journal: Vaccine [Category] SARS, 임상, [키워드] 95% CI accounted age clinical trial conducted COVID-19 COVID-19 pandemic COVID-19 vaccine decrease determine Endpoint FIVE France Gender healthcare worker individual Intention male nine pandemic Pandemics participant Perceived risk proportion refusal Result SARS-CoV-2 vaccinated against COVID-19 vaccination Vaccine Vaccine hesitancy with COVID-19 women [DOI] 10.1016/j.vaccine.2020.09.041 [Article Type] Research article
Stem Cell Based Therapy Option in COVID-19: Is It Really Promising?Review Article Published on 2020-10-012022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] Anti-inflammatory effects Cell cellular therapy China clinical clinical trial COVID-19 COVID-19 patient Efficacy Evidence feature ICTRP information investigated option other disease pharmacological agent Pneumonia public health registry respiratory problems Spread STEM stem cell the disease therapy Treatment trials virus WHO World Health Organization [DOI] 10.14336/AD.2020.0608 PMC 바로가기 [Article Type] Review Article
Clinical trial to test the efficacy of melatonin in COVID-19Article Published on 2020-10-012023-07-06 Journal: Journal of pineal research [Category] SARS, [키워드] clinical trial COVID-19 intravenous melatonin SARS-CoV-2 Sepsis [DOI] 10.1111/jpi.12683 PMC 바로가기