Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease SeverityArticle Published on 2020-11-122022-10-04 Journal: Cell [Category] Fulltext, SARS, 유전자 메커니즘, [키워드] acute COVID-19 adaptive Adaptive immune response Adaptive immunity aging antibody Antibody Response Arm Biomarker CD4 CD8 connection convalescent coronavirus COVID-19 COVID-19 disease severity CXCL10 disease disease severity Epitopes highlighting identify immune response Immunity individual IP-10 knowledge limit Limited Multiple Neutralizing antibodies Neutralizing antibody response outcomes Protective protective immunity response responses risk factor SARS-CoV-2 scarcity severe COVID-19 spike subjects T cells [DOI] 10.1016/j.cell.2020.09.038 PMC 바로가기 [Article Type] Article
SARS-CoV-2 and interferon blockadeReview Published on 2020-11-092022-10-30 Journal: Molecular Medicine [Category] COVID-19, SARS, [키워드] activate Activation Adaptive immune response block blockade Cytotoxic T cell effective Implications include innate immune system interferon Neutralizing antibodies Pathways reduce SARS-CoV-2 therapeutic viral infection [DOI] 10.1186/s10020-020-00231-w PMC 바로가기 [Article Type] Review
Bovine Interferon Lambda Is a Potent Antiviral Against SARS-CoV-2 Infection in vitroVeterinary Science Published on 2020-11-062022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] absence Adaptive immune response Against Antiviral antivirals biotherapeutic agent bovine bovine IFN-λ Cell cells circulating COVID-19 demonstrated effective epithelial expressed Health HEK-293 cell higher affinity Human human PBMC IC50 identity IFN IFN-λ in silico in vitro inhibitory concentration Interaction lack Lambda lung mucosal surfaces non-specific other respiratory virus polymorphism potent produced proinflammatory receptor reduce reduced respiratory viral infections respiratory viruses SARS-CoV-2 SARS-COV-2 infection tested therapeutic therapy These cells Toxicity Transmission Type I IFN type I IFNs variants viral infections virus [DOI] 10.3389/fvets.2020.603622 PMC 바로가기 [Article Type] Veterinary Science
Conjugation of Human β-Defensin 2 to Spike Protein Receptor-Binding Domain Induces Antigen-Specific Protective Immunity against Middle East Respiratory Syndrome Coronavirus Infection in Human Dipeptidyl Peptidase 4 Transgenic MiceArticle Published on 2020-11-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Activation acute respiratory symptoms Adaptive immune response addition adjuvant administration antibody Antigen can be used candidate vaccine cause conjugation defensin Dipeptidyl peptidase 4 domain dose effective Endoplasmic reticulum ENhance enhancing the immunogenicity HBD Human human β-defensin 2 immune response immunization intramuscular intranasal investigated lack lung Medical countermeasures MERS-CoV MERS-CoV infection mice Middle East mucosal IgA response peptidase provided pulmonary fibrosis required respiratory respiratory syndrome coronavirus S RBD Safe Signaling spike Spike protein Stress subunit suppressed vaccination Vaccine vaccine candidate viral infection [DOI] 10.3390/vaccines8040635 PMC 바로가기 [Article Type] Article
Potentials of Interferons and Hydroxychloroquine for the Prophylaxis and Early Treatment of COVID-19Article Published on 2020-10-312022-10-30 Journal: Journal of cellular immunology [Category] COVID-19, [키워드] Activation activation of inflammasome acute respiratory distress Adaptive immune response ARDS Asymptomatic benefit cause cells clinical study COVID-19 disease early stage eventually death exacerbated failure hallmark HCQ Hydroxychloroquine hyperinflammatory state IFN IFN response induce Infection Inflammatory cytokines Inflammatory response inhibit interferon ISGs Mild mild cases molecular mechanism Mortality NFκB NLRP3 obesity ongoing trial pandemic of COVID-19 Postexposure Prophylaxis Potential progression Prophylaxis randomized clinical trial RCTs responsible risk factor Severe case severe COVID-19 severe disease shown stimulate stimulated Symptom syndrome tissue damage transcription factor Treatment Type type I Type III IFN understanding viral entry Viral load [DOI] 10.33696/immunology.2.063 PMC 바로가기 [Article Type] Article
I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older PeopleI 면역노화와 염증: 고령자의 중증 COVID-19 위험 요인Review Published on 2020-10-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Adaptive immune response addition advanced age aging aging process change condition coronavirus correlation COVID-19 Cytokines decrease decreases disease disease pathogenesis dysfunction exacerbated Factor immune responses immunological immunological change immunological changes immunosenescence include individual Infection inflammaging Inflammatory cytokines Influenza involved main mechanism main mechanisms mechanism occur Older SARS-CoV-2 SARS-COV-2 infection susceptibility susceptible the disease [DOI] 10.3389/fimmu.2020.579220 PMC 바로가기 [Article Type] Review
Innate and adaptive immune responses against coronavirusReview Published on 2020-10-222023-06-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS, [키워드] Adaptive immune response Convalescent plasma therapy COVID-19 innate immune response monoclonal antibody therapy [DOI] 10.1016/j.biopha.2020.110859 PMC 바로가기 [Article Type] Review
Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation530 Published on 2020-10-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory syndrome Adaptive immune response adaptive immune system adult COVID-19 patient adult COVID-19 patients Bacterial binding binding epitope caused children complex coronavirus Coronaviruses COVID-19 COVID-19 patient Cytokine storm disease Escalation European Excessive activation exhibit explain glycoprotein histocompatibility complex hyperinflammation Hyperinflammatory Hyperinflammatory syndrome implication include Infection Interaction intercellular MHCII MIS-C motif Mutation Pandemics pathogenic Patient residue SARS virus SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike SARS-related coronaviruses selected sequence severe COVID-19 patients Shock Significance skewed staphylococcal superantigen Support supported Symptom syndrome T cell T cell receptor T cell receptors TCR TCR binding TCRs the cytokine storm the receptor-binding domain the SARS-CoV-2 therapeutic approaches Toxic shock syndrome triggered TSS unique virus with COVID-19 [DOI] 10.1073/pnas.2010722117 PMC 바로가기 [Article Type] 530
Recent findings on the Coronavirus disease 2019 (COVID-19); immunopathogenesis and immunotherapeuticsArticle Published on 2020-10-102022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 유전자 메커니즘, [키워드] activated acute respiratory syndrome Adaptive immune response adipose administration ancestor antiviral drug clinical manifestation compounds connection contributing to Coronavirus disease 2019 coronavirus disease-2019 correlated COVID-19 COVID-19 patients current Cytokine storm Defense distribution event Exhaustion extreme faster fatality favor form gut microbiota immune response immune system Immunopathogenesis Immunotherapeutics inefficient Inflammatory responses innate immune response Interaction knowledge lethal manifestation marker MERS Middle East modulate Mortality NK cell occur patients public health emergency recent recognize respiratory response responses responsible SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 severity of COVID-19 similarity T cell tested the disease Therapeutic approach tissue Transmission Treatment upregulated virus virus entry [DOI] 10.1016/j.intimp.2020.107082 PMC 바로가기 [Article Type] Article
Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis2019년 중증 또는 중대한 신종 코로나바이러스 감염증(COVID-19)과 관련된 임상 실험실 매개변수: 체계적인 검토 및 메타 분석Research Article Published on 2020-10-012022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval Adaptive immune response articles C-reactive protein calculated carried CD4 CD8 T cell cell counts children CINAHL Clinical course clinical laboratory conducted confirmed case confirmed cases coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 cases Critical Critical disease D-dimer data extraction database databases dimer eligible excluded Google Scholar innate immune response interleukin interleukin-6 Laboratory laboratory parameter lymphocyte marker meta-analyses Meta-analysis MMD MONITOR neutrophil neutrophil count notable novel coronavirus disease observational studies observational study Organ failure Other parameter predictor pregnant women proportion random effect relative reported severity systematic review systematic reviews T cell tissue damage troponin troponin I Web of Science [DOI] 10.1371/journal.pone.0239802 PMC 바로가기 [Article Type] Research Article