SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patientsResearch Published on 2020-07-172022-10-31 Journal: Experimental Hematology & Oncology [Category] COVID-19, [키워드] abnormal coagulation Admission alanine aminotransferase ALT analyzed Aspartate aminotransferase AST biochemical Biomarker Blood blood platelet cardiovascular event cascade Clinical prognosis Coagulation coagulation function Coronavirus disease 2019 coronavirus nucleic acid correlated COVID-19 COVID-19 patient COVID-19 patients death death case diagnosed diagnostic DIC disease disease severity enrolled function Hospitalization Huoshenshan Hospital IgM/IgG increased mortality increased risk INR International intravascular coagulation laboratory parameter lack Liver function Mortality non-severe group normalized occurred Other parameter Patient patients with COVID-19 Platelet positive predict Prothrombin time recovered patients Result risk SARS-CoV-2 severe disease severe group significantly subgroups survival tested thrombin thrombocytopenia Thromboembolism two groups used to evaluate viral disease while Wuhan [DOI] 10.1186/s40164-020-00172-4 PMC 바로가기 [Article Type] Research
Rationale for targeting complement in COVID‐19Review Published on 2020-07-122022-11-01 Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] activated Activation acute lung injury acute respiratory distress acute respiratory illness ARDS cascade caused cell entry China clinical trials clinically collected Community complement complement pathways complement proteins component COVID‐19 COVID‐19 Cytokine storm disease dysfunction evade Evidence health emergency immunology Immunopathogenesis immunopathology Infection information innate immune lectin pathway Macrophage manifestation Microbiology, Virology & Host Pathogen Interaction Mild multiorgan failure neutrophil Novel coronavirus offer Pathogens potential therapeutic agent rationale SARS‐CoV‐1 SARS‐CoV‐2 SARS‐CoV‐2 Sepsis Spread Support syndrome therapeutic Therapeutic strategies Therapeutics virus [DOI] 10.15252/emmm.202012642 PMC 바로가기 [Article Type] Review
COVID-19 infection during autoimmune disease: study of 2 cases in Republic of GuineaResearch Published on 2020-07-012022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, [키워드] agency Autoimmune Autoimmune disease Autoimmune diseases cascade Clinical sign COVID-19 COVID-19 infection Factor Guinea Health Immunity Infection infection with COVID-19 Inflammatory Informed consent medical records Musculoskeletal National Patient patient data patients patients with COVID-19 positive Result rheumatoid arthritis RT-PCR SDS Surveillance Systemic scleroderma tested virus was obtained worsening [DOI] 10.11604/pamj.supp.2020.35.2.24616 PMC 바로가기 [Article Type] Research
A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 PandemicPharmacology Published on 2020-06-192022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 candidate cascade clinical trial Community coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 vaccine development curtail domain drug effort event global pandemic host cell immune response individuals initiated limit lockdown novel coronavirus SARS-CoV-2 optimism pandemic phase platform potential therapies public health race SARS-CoV-2 Seven spike glycoprotein Spread subsequent targeting temper treat Vaccine Vaccine development viral spread virus [DOI] 10.3389/fphar.2020.00937 PMC 바로가기 [Article Type] Pharmacology
A cascade of causes that led to the COVID-19 tragedy in Italy and in other European Union countriesViewpoints Published on 2020-06-042022-10-31 Journal: Journal of Global Health [Category] Coronavirus, SARS, [키워드] cascade cause country COVID-19 European Italy union [DOI] 10.7189/jogh-10-010335 PMC 바로가기 [Article Type] Viewpoints
Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19Research Perspective Published on 2020-05-312022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] aging Air pollution cascade cause caused COVID-19 cytokine IL-6 Infection infection rates Inflamm-aging Inflammation Inflammatory Inflammatory cytokine lung metformin mitochondrial molecular morbidity and mortality novel coronavirus SARS-CoV-2 Older outcome overlap pandemic disease Particulate matter pathological Population Prevent proinflammatory prothrombotic risk SARS-COV-2 infection severe COVID-19 severity Signaling therapeutic therapeutic strategy thrombotic Transport Trigger [DOI] 10.18632/aging.103347 PMC 바로가기 [Article Type] Research Perspective
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2Review Article Published on 2020-05-292022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 신약개발, 임상, 치료제, [키워드] “cytokine storm” adaptive adaptive immune system approved biological processe cascade change chemokine Clinical management COVID-19 COVID-19 patients cytokine Cytokine storm Defense develop drugs dysregulation effective drug help highlight Host immune defense immune dysregulation immune response immune signaling pathway immune system immunopathology implicated Infectious diseases Inflammation Inflammatory innate response mechanism Mild molecular pathway pharmacological Prevent reflect SARS-CoV-2 SARS-COV-2 infection Severe case signaling pathway Spread stages standard care Supportive treatments systemic level therapeutic tissue damage treat Treatment triggered urgent investigation Vaccine viral infection virus virus entry widespread [DOI] 10.1038/s41392-020-0191-1 PMC 바로가기 [Article Type] Review Article
Allo-priming as a universal anti-viral vaccine: protecting elderly from current COVID-19 and any future unknown viral outbreakReview Published on 2020-05-122022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] activated Activation Anti-viral approach benefit can be used cascade cause Cell Cell therapy cells cellular chronic inflammation circulation Clinical use condition COVID-19 COVID-19 infection COVID-19 pandemic cross-reactive CTL DAMP disease effector cell elicit event Ex vivo healthy healthy donor heat shock protein immune immune system Immunity immunosenescence Immunotherapy inflammaging initiate injection limit lysed memory memory cell Multiple neutralizing antibody non-specific outbreak performed progression PROTECT provide replacing SARS-CoV-2 virus threat vaccination Vaccination strategy Vaccine variant viral disease viral infection viral outbreak viral titer [DOI] 10.1186/s12967-020-02363-3 PMC 바로가기 [Article Type] Review
Gaps in Viral Hepatitis Awareness in the United States in a Population-based StudyArticle Published on 2020-01-012023-06-11 Journal: Clinical gastroenterology and hepatology : the off [Category] B형 간염, Fulltext, [키워드] ALT cascade linkage to care Viral hepatitis [DOI] 10.1016/j.cgh.2019.05.047 PMC 바로가기
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogasterDrosophila melanogaster의 식이 의존성 요산 병리학에서 인슐린 유사 신호 전달 경로의 보존된 역할Research Article Published on 2019-08-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affecting AKT2 arising association Author benefit candidate gene cascade changes in chronic disease Chronic diseases clinical Clinical studies component components conserved Coronary artery Coronary artery disease correlation Degradation diabetes disease disorders downstream Drosophila Drosophila melanogaster drug target Effect elevated expression Factor FOXO3 Genetic Gout Human humans Hyperuricemia hyperuricosuria insulin kidney kidney stone kidney stones knockdown mechanism metabolic syndrome metabolism modulating Multiple NADPH NADPH oxidase norm obesity Occurrence opens Pathogenesis Pathologies pathology pathway phenotype plethora potential therapeutic target potential therapeutic targets Protein purine purines raise reduced Regulatory rescued Research respond risk factor serum shown Signaling signaling pathway SNP SNPs sugar Support syndrome to define treat uric acid Urine vascular disorder yeast extract [DOI] 10.1371/journal.pgen.1008318 PMC 바로가기 [Article Type] Research Article