Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In VitroArticle Published on 2021-02-112022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] Acidic acute respiratory syndrome affected Air-liquid interface anti-apoptotic Antiviral compounds antiviral drug berberine chemokines complement Concentration concentrations coronavirus COVID-19 cytokine early stage effective Efficacy Endosomes expression Human human pathogen increase in indicated Infection inhibited isolate late stage less nasal epithelial cell neutralize Obatoclax preventive measures primary target cells Protein reduced repressed SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Vaccines viral life cycle viral RNA synthesis [DOI] 10.3390/v13020282 PMC 바로가기 [Article Type] Article
Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 InfectionSARS-CoV-2 감염의 임상 결과가 좋지 않은 입학 어소시에이트의 낮은 아연 수치Observational Study Published on 2021-02-092022-09-12 Journal: Nutrients [Category] MERS, 임상, 진단, [키워드] acute respiratory syndrome Admission antiviral action Associate Biomarker cell line Chronic diseases clinical clinical outcomes concentrations coronavirus correlated correlation COVID-19 COVID-19 disease COVID-19 patient COVID-19 severity deficiency determine favor immune responses Impact in vitro result increased risk individual Infection influence Level Mortality Observational cohort study outcome outcomes Poor progression Prophylaxis randomized clinical trial Replication risk risk factor SARS-CoV-2 SARS-CoV-2 infected cells SARS-CoV2 serum severe coronavirus disease stability SZC Treatment two group Vero E6 viruses Zinc zinc supplementation [DOI] 10.3390/nu13020562 PMC 바로가기 [Article Type] Observational Study
Aerosol generation and control in the dental operatory: An in vitro spectrometric study of typical clinical setupsResearch Article Published on 2021-02-042022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] aerosol aerosol load applied Concentration concentrations COVID-19 defined dental Efficacy Efficiency Evidence generate in vitro in vitro study introduced not differ outbreak parameter patient treatment recommendation reduce resulting significantly tested Treatment [DOI] 10.1371/journal.pone.0246543 PMC 바로가기 [Article Type] Research Article
Characteristics of Viral Shedding in Respiratory Samples and Specific Antibodies Production in 564 COVID-19 Patients564명의 COVID-19 환자에서 호흡기 샘플 및 특정 항체 생산의 바이러스 배출 특성Article Published on 2021-02-012022-09-12 Journal: Current medical science [Category] MERS, 진단, [키워드] accounted age antibody antibody production antibody tests branch changes in city collected Concentration concentrations correlated correlation COVID-19 COVID-19 patient COVID-19 patients Day discharge discharged disease severity Gender had no IgG and IgM IgM Inpatient median nasopharyngeal swabs New nucleic acid Patient patients positive positive rate Production proportion quarantine reduce Reporting respiratory respiratory sample Sample SARS-CoV-2 shedding significantly Specific specific antibodies specific antibody sputum suggested symptom onset the patient throat swabs Tongji Hospital viral shedding were recorded [DOI] 10.1007/s11596-021-2316-3 PMC 바로가기 [Article Type] Article
Is there scientific evidence of the mouthwashes effectiveness in reducing viral load in Covid-19? A systematic reviewReview Published on 2021-02-012022-10-29 Journal: Journal of Clinical and Experimental Dentistry [Category] COVID-19, [키워드] appear article articles base Care carried chlorhexidine clinical Concentration concentrations COVID-19 decrease Dilution effective Effectiveness Evidence human saliva hydrogen hydrogen peroxide in viral in vitro independent Intervention Material and Method MERS-CoV Mouthwash mouthwashe mouthwashes performed peroxide reduce reducing reduction Research Result review Saliva SARS-CoV selected Seven Support systematic review tested Viral load virucidal viruses [DOI] 10.4317/jced.57406 PMC 바로가기 [Article Type] Review
Selecting Controls for Minimizing SARS-CoV-2 Aerosol Transmission in Workplaces and Conserving Respiratory Protective Equipment Supplies작업장에서 SARS-CoV-2 에어로졸 전파를 최소화하고 호흡기 보호 장비 공급을 보존하기 위한 제어 선택Article Published on 2021-01-142022-08-31 Journal: Annals of work exposures and health [Category] MERS, 치료제, [키워드] aerosol aerosol transmission assessment categories concentrations Contact Control control banding controls COVID-19 develop disease effective eliminating Evidence evidence of example focus hierarchy hierarchy of controls high risk Infection Infectious disease inhalation occupational safety and health offer organism pandemic Particle pathway Personal protective equipment prevention programs receptor Recognition reduce respiratory risk risk assessments SARS-CoV-2 supply Transmission Workplace workplace exposure. [DOI] 10.1093/annweh/wxaa083 PMC 바로가기 [Article Type] Article
Hydroxychloroquine in the treatment of adult patients with Covid-19 infection in a primary care setting (LIBERTY): A structured summary of a study protocol for a randomised controlled trial일차 진료 환경(LIBERTY)에서 Covid-19 감염 성인 환자 치료에 사용되는 하이드록시클로로퀸: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-112022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 addition addressed administration Adult patients adverse event adverse events AEs age all-cause hospitalization Antibody Response Anxiety Anxiety Disorder ARMS association Biomarker blinded Blinding Blood BMI capture Care changes changes in Characteristics clinical trial concentrations concomitant medications conducted Contact Course COVID-19 COVID-19 infection COVID-19-related symptoms criteria death deleting Demographic variables diabetes Diabetes Mellitus disease dissemination double-blind Effect element enrolment enzyme EudraCT evaluate exclusion expected exploratory exploratory endpoint Exploratory endpoints female Formulation GAD-7 Generalized Generalized Anxiety Disorder Genetic variation HCQ Health care HLA haplotypes hospital Hospitalization hospitalizations Hydroxychloroquine Hypothesis identify include Inclusion independent individual Infection information intensive care unit lactation masking mental health Meta-analysis Mortality Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples number number of deaths objective onset of symptom open care outcome Outpatient outpatients parallel-group participant Patient patient data PCR test PCR testing PCR-confirmed Placebo placebo-controlled post-hoc predict Pregnancy presenting primary care primary endpoint protocol public health public health care randomised randomised controlled trial randomization list Randomized Randomly receive recruitment reduce Registered Regulation repeated reported respiratory respiratory distress respiratory rate response risk room air SAEs Sample size SARS-CoV-2 SARS-CoV-2 PCR test SARS-CoV-2 viral shedding Satakunta secondary endpoint Secondary endpoints Secondary objectives serious AE serum Seven severe pneumonia severity specific treatment status study participant Study participants study population Study protocol subgroup analysis subject supplementary material Suspected Symptom Symptoms technology test result therapeutic potential Tolerability treated Treatment treatment allocation treatment arm Trial Trial registration twice a day type 1 or type 2 Uppsala variable Viral was performed website Well-being [DOI] 10.1186/s13063-020-04989-6 PMC 바로가기 [Article Type] Letter
Hypercalcemia as a Biomarker of Poor Prognosis in Frail Elderly Patients with COVID-19COVID-19에 걸린 노쇠한 노인 환자의 불량한 예후의 바이오마커로서의 고칼슘혈증Article Published on 2021-01-012022-09-11 Journal: The journal of nutrition, health & aging [Category] MERS, 바이오마커, [키워드] Adults age albumin Antibiotics baseline Biomarker calcium Cardiomyopathy cohort study Concentration concentrations COVID-19 COVID-19 patients defined determine elderly elderly patients exhibited functional geriatric patients Health Hospital admission Hospitalized hypercalcemia hypertension Hypocalcemia less malignancies Mortality normocalcemia Older Older adults participant patients hospitalized Poor Prognosis respiratory SARS-CoV-2 Sex survival survival time survived were assessed with COVID-19 [DOI] 10.1007/s12603-021-1690-7 PMC 바로가기 [Article Type] Article
Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19COVID-19 환자를 위한 중요한 표지자로서의 기질 금속단백분해효소 3Article Published on 2021-01-012022-09-11 Journal: Journal of medical virology [Category] 바이오마커, [키워드] analyzed biochemical center Chinese collected Concentration concentrations Control coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 COVID-19 patient Cytokines detect detection healthy individual IL-1β IL-6 Inflammation Inpatients interleukin marker matrix matrix metalloproteinase Medicine metalloproteinase MMP3 MMP3 concentrations Non-COVID-19 normality Novel coronavirus patients with COVID-19 Pneumonia positive correlation prevention Prevention and control proinflammatory cytokines sera serum Serum level serum levels Severity of disease situation SPSS statistically significant Therapeutic approach therapeutic approaches two group two groups university Wilcoxon rank sum Wilcoxon rank sum test [DOI] 10.1002/jmv.26235 PMC 바로가기 [Article Type] Article
Links between air pollution and COVID-19 in England ☆Article Published on 2021-01-012022-11-01 Journal: Environmental pollution (Barking, Essex : 1987) [Category] COVID-19, MERS, SARS, [키워드] Abstract addition Affect affected age Air pollution assessment average caused China concentrations coronavirus disease country COVID-19 COVID-19 case COVID-19 cases COVID-19 infection COVID-19 mortality database death death rates deaths died disease emission England Factor global pandemic Health humans Image increase in Level median Mortality mortality rate Nitrogen oxides Novel coronavirus Ozone pandemic Patient PM10 PM2.5 positive provide recent Regional reported SARS-CoV-2 severity UK biobank UK Biobank data variables Variation virus while Wuhan [DOI] 10.1016/j.envpol.2020.115859 PMC 바로가기 [Article Type] Article