Aromatic Herbs, Medicinal Plant-Derived Essential Oils, and Phytochemical Extracts as Potential Therapies for Coronaviruses: Future PerspectivesReview Published on 2020-06-262022-10-28 Journal: Plants [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV 2019-nCoV infection addition Antiviral antiviral activity antiviral drugs Antiviral treatment approved drug aromatic China Compound compounds coronavirus 2 Coronavirus infection Coronaviruses COVID-19 CoVs develop discharge drugs Effects Essential essential oils Extract Future herbal medicine herbal medicines Host in vitro in vivo interfere interferon Intervention mechanism medicinal plants MERS-CoV novel antiviral drugs Numerous outbreak Patient phytochemical phytochemicals plants Pneumonia Potential predicted Replication respiratory SARS-CoV SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Side effects Spread targets therapeutic use Therapies Treatment Vaccine Vaccines viral entry viral life cycle Viral resistance virus Wuhan [DOI] 10.3390/plants9060800 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Evolutionary Adaptation toward Host Entry and Recognition of Receptor O-Acetyl Sialylation in Virus–Host InteractionReview Published on 2020-06-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acquisition activate adaptation antiviral therapeutics binding bovine caused classical conformational contribute coronavirus disease CoV CoV infection COVID-19 CoVs Cross-species transmission domains driven by entry receptor enzyme Evidence Evolution evolutionary adaptation example expected Factors glycans glycosylation Health Hemagglutinin-esterase horizontal gene Host host cells host tropism hosts infected patients Influenza virus influenza viruses information initial Interaction Lineage molecular MOST murine non-structural protein occur outbreak pandemic principle proceed Protein receptor Recognition recognize recognizing reflect Research SARS CoV-2 SARS-CoV-2 sialic acid sialic acid O-acetylation spike glycoprotein subtype switching therapeutic therapeutic drug transfer transmitted Trial Type type I vaccination virus virus–host interaction zoonotic disease β-CoV [DOI] 10.3390/ijms21124549 PMC 바로가기 [Article Type] Review
SARS-CoV-2: An Update on Potential Antivirals in Light of SARS-CoV Antiviral Drug DiscoveriesReview Published on 2020-06-232022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 2019-nCoV anti-SARS-CoV-2 antibodies Antiviral antivirals CoV COVID-19 CoVs death deaths described different disease drug drugs effective Fatality rate group Human humans illnesses in vitro in vivo infections life-threatening LIGHT MERS-CoV Middle East mild respiratory MOST outbreak Patient Potential Research resource respiratory resulting RNA virus Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 replication sequence identity severe respiratory disease Severe respiratory distress shown Spread spread to syndrome therapeutic strategy treat Viral pneumonia virus Wuhan, China [DOI] 10.3390/vaccines8020335 PMC 바로가기 [Article Type] Review
Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronavirusesArticle Published on 2020-06-182022-11-01 Journal: International immunopharmacology [Category] COVID-19, SARS, [키워드] adjuvant adjuvants Antigen caused coronavirus country COVID-19 CoVs decrease develop effective effort elicit globe host cell immunostimulatory molecules induce levels of antibodies levels of antibody MERS multiple dose neutralizing antibody pandemic Potential Prevent Protective receptors respiratory SARS SARS-CoV-2 SARS-CoV-2 vaccine the disease the vaccine Vaccine virus [DOI] 10.1016/j.intimp.2020.106717 PMC 바로가기 [Article Type] Article
A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis코로나바이러스 복제 소기관의 통합 구조 및 기능 모델: RNA 합성 추적Research Article Published on 2020-06-082022-08-13 Journal: PLoS Biology [Category] COVID-19, Medicine and Health Sciences, SARS, [키워드] acute respiratory syndrome Analysis assortment autoradiography beta-CoV Cell cellular complex coronavirus Coronavirus replication CoV CoV infection CoV RNA-synthesizing machinery CoV RO CoVs disparate drug target element endomembrane endoplasmic reticulum membrane followed by functional induce infected cells Infection infections Infectious Bronchitis Virus international public health labeling membrane modifications membrane structures MERS-CoV metabolic Microscopy Middle East observation open organelle pan-CoV RO element pandemic Quantitative Replication respiratory responsible RNA synthesis SARS-CoV SARS-CoV-2 spherule thought Vesicle Viral viral replication Viral RNA viral RNA synthesis Zoonotic coronavirus [DOI] 10.1371/journal.pbio.3000715 PMC 바로가기 [Article Type] Research Article
Virtual screening and repurposing of FDA approved drugs against COVID-19 main proteaseResearch article Published on 2020-06-012022-10-05 Journal: Life sciences [Category] SARS, 신약개발, 치료제, [키워드] 2019 New Coronavirus 2019-nCoV2019 New Coronavirus 3-C-like protease 3CLpro3-C-like protease acting addition Antiviral approved Comparisons Coronavirus disease 2019 CoV COVID COVID-19 COVID-19coronavirus disease 2019 CoVs dataset docking drug drugs EEnvelope envelope Epidemics FDA approved drug investigated knowledge material membrane protein MERS MERS CoVMiddle East Respiratory Syndrome Coronavirus Middle East respiratory syndrome Coronavirus Mmembrane protein MPro nicotinamide NNucleocapsid nucleocapsid open reading frames ORFopen reading frames Phylogenetic phylogenetics protease provided Research resolved ribavirin Safe SARS CoV SARSSevere Acute Respiratory Syndrome CoV sequence Severe Acute Respiratory Syndrome CoV Significance Spike protein Sspike protein systemically Treatment Virtual screening virus Vitamin vitamin B12 Wuhan, China [DOI] 10.1016/j.lfs.2020.117627 [Article Type] Research article
A virus that has gone viral: amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding, and thus, infectivityVirology Published on 2020-05-292022-10-28 Journal: Bioscience Reports [Category] COVID-19, MERS, SARS, [키워드] ACE2 Alter Amino acid Analysis arginine binding caused coronavirus Course COVID-19 CoVs domain GenBank Genome genome sequence hydrophobic amino acid India information isolate isolates MERS-CoV in 2012 Mutation Novel coronavirus outbreak Outbreaks performed Point mutation Protein RBD receptor Receptor binding replaced reported S protein SARS-CoV SARS-CoV- SARS-CoV-2 secondary structure sequence sequenced Sequencing spike structural protein the Spike therapeutic targeting Vaccine Virology virus virus entry while Wuhan isolate Wuhan, China zoonotic [DOI] 10.1042/BSR20201312 PMC 바로가기 [Article Type] Virology
Vulnerabilities in coronavirus glycan shields despite extensive glycosylationArticle Published on 2020-05-272022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Clusters complex coronavirus CoVs epitope Epitopes Fatality rate fusion protein glycan glycobiology glycoprotein Glycoproteins glycosylated glycosylation high-density HIV-1 HKU1 humoral immune response immune evasion immunogenic immunological influenza hemagglutinin MERS Middle East N-linked glycosylation Neutralizing pandemic Protein Proteins S protein shielding spike syndrome trimeric spike Viral immune evasion Viral protein viral spike virus glycoprotein vulnerability zoonotic pathogen [DOI] 10.1038/s41467-020-16567-0 PMC 바로가기 [Article Type] Article
Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2Review Published on 2020-05-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] anti-inflammatory compounds Antibiotics antiparasitic agent Antiretrovirals bortezomib caused Cell cellular homeostasis compounds consequence Convalescent patients coronavirus COVID-19 CoVs Deleterious Effect effective endoplasmic stress global pandemic Immunological response in viral inflammatory conditions inhibitor MG132 off-label Oxygen administration Patient plasma proteasome proteasome inhibitors protein expression reduce Replication RNA SARS-CoV-2 subsequent supportive care the cytokine storm therapeutic therapy treated Treatment triggered UPR response virus entry virus replication [DOI] 10.3390/ijms21103622 PMC 바로가기 [Article Type] Review
Porcine Epidemic Diarrhea Virus and the Host Innate Immune ResponseReview Published on 2020-05-112022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Antiviral cause coronavirus country CoV CoVs cytokine Defense diarrhea disrupt effective vaccine effector elicit epidemic diarrhea evade expression help highlight Host IFN antagonist IFN response IFNs immune immune evasion induce Infection Innate innate immune innate immune response Innate immunity Interaction involved mechanism pathway PEDV Porcine epidemic diarrhea virus provide response robust Type I IFN viral infections Viral RNA virus watery [DOI] 10.3390/pathogens9050367 PMC 바로가기 [Article Type] Review