Gene therapies and COVID-19 vaccines: a necessary discussion in relation with viral vector-based approachesLetter to the Editor Published on 2021-07-162022-10-29 Journal: Orphanet Journal of Rare Diseases [Category] COVID-19, SARS, [키워드] AAV Adenovirus AdV Advanced therapies affected approach benefit Community COVID-19 COVID-19 pandemic COVID-19 vaccine cross-reactivity Efficacy elicited Frequency Gene therapy genetic disease Genetic diseases genetic disorder group immune response implication information MOST pandemic Patient physician rare diseases SARS-CoV-2 serotype Therapies therapy Treatment Vaccine Viral vector viral vector-based virus [DOI] 10.1186/s13023-021-01958-3 PMC 바로가기 [Article Type] Letter to the Editor
Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronavirusesSARS-COV-2 및 기타 인간 코로나 바이러스에 대한 COVID-19 환자의 면역 반응 역학Clinical Trial Published on 2021-07-092022-09-10 Journal: PLoS ONE [Category] SARS, 비임상, 임상, 진단, 치료법, [키워드] 229E anti-N antibodies anti-N antibody antibody Antibody titers appearance binding domain breath candidate CCL5 chemokines coronavirus coronavirus strain COVID-19 COVID-19 patient COVID-19 patients cross-reactivity CXCL-10 demonstrated disease elevated Eotaxin FIVE HCoVs Health HKU1 human coronavirus IgG IgG and IgM IgG1 IgG2 IgG3 IgG4 Inflammatory Inflammatory cytokines IP-10 MCP-1 MERS MERS-CoV multiplex N protein NL63 Non-COVID-19 nucleocapsid OC43 Patient peaking Protein Quantitative RANTES Receptor binding domain remained S protein S-RBD SARS-CoV SARS-CoV viruses SARS-CoV-2 sensitivity serological test specificity Subtypes Symptoms undetectable Vaccine [DOI] 10.1371/journal.pone.0254367 PMC 바로가기 [Article Type] Clinical Trial
COVID diagnostics by molecular methods: A systematic review of nucleic acid based testing systems분자적 방법에 의한 코로나 진단: 핵산 기반 검사 시스템의 체계적인 검토Article Published on 2021-07-012022-09-11 Journal: Indian journal of medical microbiology [Category] MERS, 진단, 치료기술, [키워드] addressed article assays CBNAAT clinical laboratories clinical samples COVID COVID-19 cross-reactivity data extraction detection rate diagnostic diagnostic services diagnostic test diagnostics E-gene early stage early stages Efficiency eligibility equipment estimate expected false-negative False-positive Final healthcare worker Healthcare workers inclusion criteria Inconclusive Interpretation isothermal amplification item limitation molecular Molecular assay molecular assays nucleic acid pandemic virus PCR question reported Reporting respiratory retrieved review RT-PCR SARS CoV SARS CoV-2 SARS-CoV-1 SARS-CoV-2 systematic review systematic review and meta-analysis Test Variability Variation viruses was done were excluded [DOI] 10.1016/j.ijmmb.2021.05.012 PMC 바로가기 [Article Type] Article
Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test developmentSARS-CoV-2에 대한 항체 반응의 펩티드 마이크로어레이 기반 분석은 진단 테스트 개발 가능성이 있는 고유한 에피토프를 식별합니다.Article Published on 2021-07-012022-09-11 Journal: European Journal of Immunology [Category] SARS, 진단, 치료법, [키워드] 229E Analysis antibody antibody cross-reactivity Antibody Response antibody tests antigens binding capture capture antigen control sample controls coronavirus COVID-19 COVID-19 patient COVID-19 patients cross-reactivity diagnostic diagnostic antibody diagnostics ELISA epitope HCoV HCoVs human coronavirus identify IgG immune protection Immunity immunodominant implication MERS Microarrays nucleocapsid OC43 Patient peptide peptide microarray peptide microarray. peptides provided Region respiratory SARS-CoV-2 SARS-CoV-2 proteome screened statistically significant strain the Spike unique while widespread [DOI] 10.1002/eji.202049101 PMC 바로가기 [Article Type] Article
Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study7 개의 상업용 SARS-COV-2 빠른 시점 항원 테스트 비교 : 단일 센터 실험실 평가 연구Articles Published on 2021-07-012022-09-06 Journal: The Lancet. Microbe [Category] Communicable Disease, MERS, SARS, 치료기술, [키워드] 95% CI Abbott Abbott Panbio COVID-19 Ag Rapid Test accelerate Affair AgPOCT AgPOCTs analytical sensitivity Antigen Antigen point-of-care test assays Biocredit COVID-19 Ag Care cassette Cell culture clinical sample clinical samples Concentration coronavirus Coronaviruses COVID-19 COVID-19 Ag Respi-Strip cross-reactivity cumulative Cumulative specificities Cumulative specificity Decision making Endemic endemic human coronavirus energy evaluated False-positive results finding FIVE foundation funding generate HCoV HCoV-HKU1 supernatant HCoV‑229E HCoV‑HKU1 HCoV‑NL63 HCoV‑OC43 Healgen Healgen assay Healgen Coronavirus Ag Rapid Test Cassette Health Health care healthy volunteer healthy volunteers Horizon Infection infectious Laboratory limit of detection Melinda Gate Melinda Gates MERS MERS-CoV Ministry of Health Most patients nal von minden nal von minden NADAL COVID-19 Ag Test outlier overlap PanBio Pathogens Patient patients point-of-care positive public health quantified R-Biopharm ranged Rapid Rapid test RapiGEN RapiGEN BIOCREDIT COVID-19 Ag real-time RT-PCR recombinant SARS-CoV-2 nucleoprotein Research respiratory respiratory pathogen Respiratory pathogens Respiratory samples RIDA Roche Roche-SD Biosensor Roche-SD Biosensor SARS-CoV Rapid Antigen Test RT-PCR SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 testing SARS-CoV-2 viral load SARS-CoV-2 viral loads sensitivity Seven specificity stored respiratory sample stored respiratory samples Swab Symptoms Test test results tissue culture tissue culture supernatant tissue culture supernatants utility Viral Viral concentration Viral load viral loads virus concentration [DOI] 10.1016/S2666-5247(21)00056-2 PMC 바로가기 [Article Type] Articles
Humoral Immunity against SARS-CoV-2 and the Impact on COVID-19 PathogenesisSARS-CoV-2에 대한 체액 면역 및 COVID-19 발병에 미치는 영향Review Published on 2021-06-302022-09-11 Journal: Molecules and cells [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses antibody treatment autoreactive antibodies autoreactive antibody circulating SARS-CoV-2 variants coronavirus coronavirus disease Coronavirus disease 2019 correlation correlations COVID-19 COVID-19 patients cross-reactivity disease severity Efficacy highlight humoral humoral immune response humoral immune responses Humoral immunity immune immune response immune responses Impact knowledge memory B-cell Neutralizing antibodies neutralizing antibody provided respiratory response SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus therapeutic Vaccine Vaccine development [DOI] 10.14348/molcells.2021.0075 PMC 바로가기 [Article Type] Review
COVID-19 (SARS-CoV-2) lymphocyte responses are associated with inflammatory biomarkers in total joint replacement surgery candidates pre-operativelyCOVID-19(SARS-CoV-2) 림프구 반응은 수술 전 총 관절 교체 수술 후보의 염증성 바이오마커와 관련이 있습니다Research Article Published on 2021-06-302022-09-10 Journal: Journal of Orthopaedic Surgery and Research [Category] MERS, SARS, 바이오마커, 치료법, [키워드] addition analyzed antibodies antibody antibody production Blood candidate Cohort coronavirus COVID-19 cross-reactivity elective surgeries Elective surgery exhibited exposure to General population IgG antibodies IgG antibody IL-1ra IL-1β IL-6 Immunity Inflammatory biomarker inflammatory biomarkers joint LTT lymphocyte lymphocyte response lymphocyte responses Lymphocytes median age memory nucleocapsid nucleocapsid protein Nucleocapsid proteins parameter Patient peripheral Peripheral blood positive pre-vaccination pro-inflammatory biomarkers profiles protective immunity Protein reactive reactivity recent Registered response Result Retrospective study risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 nucleocapsid SARS-CoV-2 virus serum spike and nucleocapsid proteins Spike protein Spike proteins T cell T cell memory the SARS-CoV-2 the SARS-CoV-2 virus the Spike the spike protein TNFα Total Total joint arthroplasty Trial registration vaccination vaccination Methods [DOI] 10.1186/s13018-021-02563-7 PMC 바로가기 [Article Type] Research Article
A rapid near-patient detection system for SARS-CoV-2 using saliva타액을 사용한 SARS-COV-2에 대한 빠른 근적 인 검출 시스템Article Published on 2021-06-282022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] Accuracy Analysis analytical sensitivity Assay systems Biotechnology Chain Reaction Combination costly COVID-19 cross-reactivity detection system develop Device equipment increase Infectious diseases International isothermal amplification Laboratory LAMP limit of detection Loop-mediated isothermal amplification molecular naked eye positive reagent reagents reduce reference standard Regulatory reverse transcriptase reverse transcriptase-polymerase chain reaction room temperature RT-LAMP RT-PCR RT-PCR tests Saliva sample collection SARS-CoV-2 Spread temperature test results time-consuming viral infection virus widespread [DOI] 10.1038/s41598-021-92677-z PMC 바로가기 [Article Type] Article
COVID-19 Antibody Detecting Rapid Diagnostic Tests Show High Cross-Reactivity When Challenged with Pre-Pandemic Malaria, Schistosomiasis and Dengue SamplesArticle Published on 2021-06-252022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] antibodies antigens approval category COVID-19 cross-reactive cross-reactivity Dengue disease EDTA IgM independent malaria median value Pathogens Patient Plasmodium ranged Rapid RDT RDTs regions Regulatory Retrospective study risk Sample SARS-CoV-2 SARS-CoV-2 seroprevalence Schistosomiasis selected serum show Test tropical was performed Whole blood [DOI] 10.3390/diagnostics11071163 PMC 바로가기 [Article Type] Article
Severe Clinical Worsening in COVID-19 and Potential Mechanisms of Immune-Enhanced DiseaseMedicine Published on 2021-06-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Activation acute respiratory distress aggravate alleviate alveolar antibodies antibody Asymptomatic autoantibody candidate candidate vaccine Cell clinical Clinical deterioration contribute COVID-19 COVID-19 patient Critical Critical disease cross-reactivity direct infection disease disease severity driving dysregulated immune response Effects epithelia evaluate fatal COVID-19 help host proteins Hyperinflammatory immune cells immune response Infection inflammatory monocyte inquiry Laboratory macrophages majority mechanism Mild monocyte monocytes/macrophages NETs Neutrophil extracellular trap outcomes pathology Patient platelet apoptosis Potential producing receptor SARS-CoV-2 SARS-CoV-2 coronavirus severe COVID-19 severe disease progression severity subset Support therapeutic thrombosis Vaccines viral entry viral tropism while worsening [DOI] 10.3389/fmed.2021.637642 PMC 바로가기 [Article Type] Medicine