endothelial – Page 21 – Communicable Diseases Research

Bovine Serum Albumin-Coated Niclosamide-Zein Nanoparticles as Potential Injectable Medicine against COVID-19

Article

Published on 2021-07-072022-10-30
Journal: Materials [Category] COVID-19,

Endothelial cell infection and dysfunction, immune activation in severe COVID-19

내피 세포 감염 및 기능 장애, 심한 Covid-19에서의 면역 활성화

Research Paper

Published on 2021-07-062022-09-10
Journal: Theranostics [Category] MERS, SARS, 진단, 치료기술,

[키워드] Activation adhesion alveolar septa animals body weight Body weight loss Brain infection cadherin cause Cell circulation Coagulation collected complement conducted contribute correlated COVID-19 COVID-19 disease COVID-19 patients cytokine Deceased develop downregulation dysfunction edema electron microscopy endothelial Endothelial cell endothelial cells Endotheliitis Eosinopenia epithelial cells evidenced fatality hemorrhage ICAM1 immune activation Immune cell immune cells immunostaining infect Infection initial Injury interstitial inflammation K18 K18-hACE2 lung Lung epithelial cells Lungs lymphocytopenia mice Microscopy NHP NHP models organ organs Pathogenesis pathway Pathways Patient perivascular inflammation Platelet Platelets Pneumonia pulmonary PULMONARY VESSELS rationale Result RNA-seq analyses SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe COVID-19 disease severity Signaling Single Cell up-regulation upregulated Vascular VCAM1 VE-cadherin vessel weight loss while
[DOI] 10.7150/thno.61810 PMC 바로가기 [Article Type] Research Paper

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants

Original Contribution

Published on 2021-07-052022-10-28
Journal: Basic Research in Cardiology [Category] COVID-19, Fulltext,

[키워드] ACE2 angiotensin-converting enzyme 2 B.1.1.7 B.1.351 caused Cell cellular distribution clearance Coronavirus disease 2019 COVID-19 direct infection double-stranded EDEM1 Effect Effects elevated endothelial Endothelial cell endothelial cells Endothelial dysfunction ER stress expressed Health higher risk highest Human in vitro Increased induce Infection Infectious virus Inflammation inoculated lung marker misfolded protein Mortality novel coronavirus SARS-CoV-2 P.2 Patient pro-inflammatory promote receptor reduced required responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant significantly higher Spike protein supernatant supplementary material susceptibility susceptible tested the SARS-CoV-2 the spike protein umbilical variant vascular bed Viral RNA viral spike protein virus infection virus replication Virus trapping wild type
[DOI] 10.1007/s00395-021-00882-8 PMC 바로가기 [Article Type] Original Contribution

Novel pulmonary vascular imaging signs in COVID-19: pathophysiology, significance and management

Opinion

Published on 2021-07-052022-10-28
Journal: BJR Open [Category] COVID-19,

[키워드] biochemical COVID-19 demonstrated endothelial Evidence exploration Health immune management novel pathophysiology pericyte potential therapy thrombotic Treatment Vascular
[DOI] 10.1259/bjro.20210001 PMC 바로가기 [Article Type] Opinion

Endothelium Activation Markers in Severe Hospitalized COVID-19 Patients: Role in Mortality Risk Prediction

Original Article

Published on 2021-07-042022-10-29
Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19,

[키워드] abnormality Activation analyzed Bergamo C reactive protein characterized Coagulation Cohort COVID-19 COVID-19 patient COVID-19 patients CRP cumulative D-dimer death elevated endothelial Endothelium enrolled Evidence exacerbated Factor fibrinogen fibrinolytic FVIII group highest hospital Hospitalized hypercoagulability Hypercoagulation ICU identify in-hospital mortality incidence Increased Infection Inflammation Inflammatory biomarker inflammatory status intensive care Italy linear median age median time multivariable analysis neutrophil non-ICU nucleosomes occurred paO2/fiO2 Patient patients plasma prediction Predictive procalcitonin Prospective Study Protein provide provided Result role SARS-COV-2 infection SARSCoV-2 severity significantly the disease variables von Willebrand factor were assessed were measured
[DOI] 10.1055/s-0041-1731711 PMC 바로가기 [Article Type] Original Article

Extracellular vesicle‐mediated endothelial apoptosis and EV‐associated proteins correlate with COVID‐19 disease severity

Research Article

Published on 2021-07-032022-10-29
Journal: Journal of Extracellular Vesicles [Category] COVID-19,

[키워드] acute respiratory syndrome affected Apoptosis approach Better caused circulating Comorbidity correlation COVID‐19 COVID‐19 patient Critically ill deaths disease disease severity EN‐RAGE endothelial Endothelial cell endothelial injury EVs extracellular vesicle global pandemic Hospitalization hospitalized patient IL‐18R1 IMPROVE Infection Inflammation Inflammatory moderate disease outcome Pathogenesis patient hospitalization patients proinflammatory Protein rising SARS‐CoV‐2 SARS‐CoV‐2 significant enrichment Stage Support symptomatic therapeutic targets thrombosis Treatment uninfected control
[DOI] 10.1002/jev2.12117 PMC 바로가기 [Article Type] Research Article

Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality

혈장의 태반 성장 인자 수준은 COVID-19 심각성과 병원 내 사망률을 예측합니다

Article

Published on 2021-07-012022-09-11
Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 바이오마커,

[키워드] 95% CI 95% confidence interval adjusted Admission age Analysis Angiogenesis Angiogenic association best Biomarker body mass body mass index C-reactive protein circulating coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 adult patients COVID-19 infection COVID-19 patients COVID-19 severity Cox proportional hazard model D-dimer diagnostic endothelial endothelial injury enrolled FGF-2 fibroblast fibroblast growth factor growth factor hospitalized patient in-hospital mortality Infection Kaplan-Meier survival curve Level logistic regression model marker Mild Mortality Odds ratio Outpatient Patient patients hospitalized placental placental growth factor plasma PlGF positive predict Predictive receiver operating characteristic respiratory Respiratory disease severity significantly survival analysis survival curve the disease Therapeutic approach Vascular vascular inflammation VEGF was performed were measured with COVID-19
[DOI] 10.1111/jth.15339 PMC 바로가기 [Article Type] Article

Acute pulmonary hypertension and short-term outcomes in severe Covid-19 patients needing intensive care

집중 치료가 필요한 중증 코로나19 환자의 급성 폐고혈압과 단기 예후

Observational Study

Published on 2021-07-012022-09-11
Journal: Acta Anaesthesiologica Scandinavica [Category] SARS, 바이오마커, 임상,

[키워드] acute pulmonary hypertension affected cardiac failure collected COVID-19 COVID-19 patients COVID-19 pneumonia criteria Critically ill develop echocardiography Embolism endothelial hypertension increase in Inflammation Intensive intensive care intensive care unit intensive care units marker median medical record medical records Mortality mortality rate myocardial injury Occurrence outcome pathophysiology Patient patients patients treated plasma Prevalence promote pulmonary artery pulmonary artery pressure pulmonary hypertension pulmonary vascular resistance receiving sequence severely ill COVID-19 patients tricuspid tricuspid valve tricuspid valve regurgitation. troponin troponin T TTE university hospital Vascular Vascular resistance ventricular were measured
[DOI] 10.1111/aas.13819 PMC 바로가기 [Article Type] Observational Study

Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation

Physiology

Published on 2021-06-252022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?

Endocrinology

Published on 2021-06-232022-10-31
Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS,

[키워드] ACE ACE inhibitors ACE2 activated ADAM9 AGT Angiotensin-converting enzyme aptamer case-control study Cell class clinical co-expressed cofactor Control controls COVID-19 determine disintegrin elevated endothelial ENhance enzyme Glucose growth factor hypoglycemia Increased increased risk inhibitor Ligand mechanism Neuropilin-1 no difference not differ not different NRP1 plasma plasma protein promote protection Protective proteolytic RAS Registration remained REN response Result SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection SEMA3A serum slow stratified Stress subject subsequent System T2D therapy Type type 2 diabete type 2 diabetes VEGF
[DOI] 10.3389/fendo.2021.665134 PMC 바로가기 [Article Type] Endocrinology