SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host DefensesSARS-CoV-2는 호스트 방어를 억제하기 위해 스플라이싱, 번역 및 단백질 트래피킹을 방해합니다.Article Published on 2020-11-252022-09-11 Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus bind cause cell membrane cellular cellular processe coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disrupt Disruption domain engage function Host host defenses Infection Interaction interfere interferon interferon response leads molecular basis mRNA mRNA splicing mRNA translation nsp1 nsp16 NSP8 Nsp9 Protein protein trafficking protein translation respiratory Respiratory disease ribosomal RNA ribosome RNA RNA-protein interactions RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 snRNA splicing suppress the cell the interferon translation Viral viral infection [DOI] 10.1016/j.cell.2020.10.004 PMC 바로가기 [Article Type] Article
COVID-19 pneumonia: the great radiological mimickerEducational Review Published on 2020-11-232022-10-29 Journal: Insights into Imaging [Category] COVID-19, [키워드] acute respiratory syndrome aspiration pneumonia caused change Chest CT Combination consolidations coronavirus Coronavirus disease 2019 COVID-19 creating CT finding described Diagnosis diagnostic differential diagnose differential diagnoses differential diagnosis disease feature GGO GGOs ground-glass opacity hemorrhage include Infarction interfere Interstitial lung diseases less longitudinal lung abnormality Lung pathology Mimicker Neoplasms non-infectious disease Organizing pneumonia Pneumonia Pulmonary alveolar proteinosis Pulmonary edema radiological reported RT-PCR sarcoidosis SARS-CoV-2 sensitivity septal thickening Spread the disease tomography [DOI] 10.1186/s13244-020-00933-z PMC 바로가기 [Article Type] Educational Review
Screening of Natural Products Targeting SARS-CoV-2–ACE2 Receptor Interface – A MixMD Based HTVS PipelineChemistry Published on 2020-11-192022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome applied binding caused classical complexes compounds conformation coronavirus COVID-19 COVID-19 infection COVID-19 pandemic domain effective expected Health highest binding affinity host cell human cell identify inhibitor Interaction interface interfere MD simulation mixed solvent molecular dynamics simulation Molecular dynamics simulation natural natural product Potential predicted Prevent probe product Protein protocol RBD-ACE2 receptor replicate S-protein SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Screening selected solvent spike Spike protein stability Support targeting Vaccines Virtual screening virus entry were used [DOI] 10.3389/fchem.2020.589769 PMC 바로가기 [Article Type] Chemistry
Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeysArticle Published on 2020-11-132022-10-04 Journal: Nature Communications [Category] SARS, 변종, 신약개발, 치료제, [키워드] ACE2 ADE angiotensin-converting enzyme 2 antibodies antibody Antibody-dependent enhancement Antiviral binding block characterization convalescent patient COVID-19 disrupting eliminated Fc region FcγRIIb Infection Interaction interfere Intervention LALA mAb monoclonal antibody Mutation Neutralizing activity neutralizing antibody non-human primates potent prevented Prophylactic prophylactic treatment RBD receptor Receptor binding domain Rhesus monkey Rhesus monkeys SARS-CoV-2 SARS-CoV-2 spike single dose therapeutic activity therapeutic effect therapeutic efficacy Therapeutic treatment Translational immunology Treatment [DOI] 10.1038/s41467-020-19568-1 PMC 바로가기 [Article Type] Article
The Need for Ocular Protection for Health Care Workers During SARS-CoV-2 Outbreak and a Hypothesis for a Potential Personal Protective EquipmentSARS-CoV-2 발병 시 의료 종사자를 위한 안구 보호의 필요성 및 잠재적 개인 보호 장비에 대한 가설Public Health Published on 2020-11-122022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, [키워드] Academy anti-viral activity Appropriate Asymptomatic carriers broad spectrum caused Clinical practice clinics Concentration conformation Contact contact lens Contamination coronavirus Critical droplet effective entry receptor equipment eye surgery Goggles griffithsin Health care Health care worker health care workers health system health systems high risk high risk patients higher risk infected with SARS-CoV-2 inhibit interfere majority mandatory manifestation medical staffs moderate moderate to severe non-toxic ocular ocular protection ophthalmology organization organizations outbreak Patient patients Personal protective equipment Physical examination positive Potential Practitioner protection Protective reduce reported risk of infection SARS-CoV SARS-CoV-2 shown Side effects Spike protein Spike proteins surgery sustained releasing contact lens transmission of SARS-CoV-2 Viral Viral RNA viruses vision water WHO worker [DOI] 10.3389/fpubh.2020.599757 PMC 바로가기 [Article Type] Public Health
Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?Pharmacology Published on 2020-11-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activate acute respiratory syndrome adaptive Anti-viral Antiviral Antiviral compound antiviral drug approach approaches approved drug benefit cause chaperone clinical development clinical trials coronavirus Course COVID-19 COVID-19 pandemic COVID-19 patients CoVs Drug repurposing drugs Endoplasmic reticulum ER membranes ER stress expected facilitate Health host cell host cell response host protein identify in vitro Infection infections interact Interaction interfere Intervention Ligand mechanism Medicine membrane-bound modulation occur pathway patients potential mechanism Prevent professional protective immune response Proteins provide receptor reduce regulate Repurposed drugs repurposing SARS-CoV-2 SARS-CoV-2 protein sigma-1 receptor Stress targeting the disease therapeutic therapy treat unique upstream viral replication [DOI] 10.3389/fphar.2020.582310 PMC 바로가기 [Article Type] Pharmacology
Dealing With the COVID-19 Infodemic: Distress by Information, Information Avoidance, and Compliance With Preventive MeasuresPsychology Published on 2020-11-052022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] adaptive Analysis Anxiety avoidance Cancer caused Compliance conducted consequence coronavirus disease COVID-19 develop distress domain effective Ehealth literacy emotional distress female Health Hypothesis in some individual individuals induce information Information avoidance interfere management measure media Multiple linear regression pandemic predict Prevent preventive measure preventive measures reduced respond screenings seeking shown spread of COVID-19 Support trust in media turn [DOI] 10.3389/fpsyg.2020.567905 PMC 바로가기 [Article Type] Psychology
Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus-2Article Published on 2020-11-022022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] analyzed Antigen attribute B-cell bioinformatics caused computational analysis coronavirus COVID-19 COVID-2019 epitope Fatality rate global pandemic greater Health histocompatibility complex HLA host immune responses immunogenic immunoinformatics Infectious disease interfere leukocyte MHC MHC class I molecular docking analysis N protein nucleocapsid nucleocapsid protein peptide Phylogenetic analysis positive predicted progression Protein provide respiratory responsible SARS-CoV-2 sequence T-cell the disease Vaccine vaccine candidates Vaccine design viral replication WHO World Health Organization [DOI] 10.3390/molecules25215088 PMC 바로가기 [Article Type] Article
Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods경미한 영향을 받은 COVID-19 회복기 환자의 낮은 혈청 중화 항-SARS-CoV-2 S 항체 수준이 두 가지 다른 검출 방법으로 밝혀짐Article Published on 2020-11-022022-09-11 Journal: Cellular and Molecular Immunology [Category] Fulltext, MERS, 진단, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected age angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-SARS-CoV-2 S anti-SARS-CoV-2 S1 IgG antibodies antibody binding biosafety Cell clinical symptom Clinical symptoms convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated correlated strongly COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients Donor ELISA enzyme faster IgA antibodies Infection interfere less Neutralization assay neutralization test Neutralizing Neutralizing antibodies neutralizing antibody passive antibody therapy Patient patient age plasma Predictive markers Prevalence RBD Receptor-binding domain respiratory S protein S1 IgG SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike sera serum serum antibodies serum antibody severe acute respiratory syndrome Coronavirus severity stomatitis surrogate virus neutralization test sVNT the receptor-binding domain the SARS-CoV-2 vesicular stomatitis vesicular stomatitis virus viral infection virus neutralization test VSV [DOI] 10.1038/s41423-020-00573-9 PMC 바로가기 [Article Type] Article
Improved binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesisSARS-CoV-2 Envelope 단백질과 밀착 연접 관련 PALS1의 향상된 결합은 COVID-19 발병에 중요한 역할을 할 수 있습니다Article Published on 2020-11-012022-09-11 Journal: Microbes and infection [Category] SARS, 유전자 메커니즘, [키워드] Amino acid amino acid sequence amplifying Analysis bat bats binding C-terminal COVID-19 COVID-19 pathogenesis docking E protein envelope envelope protein epithelial Evidence GenBank Genome genomic sequence GISAID Improved in silico Inflammatory interfere junctions key factor knowledge mechanism MOST open PALS1 pangolin pangolins pathogenic Protein raise route SARS-CoV SARS-CoV-2 sequence significant difference tight junction tight junctions tissue remodelling [DOI] 10.1016/j.micinf.2020.08.006 PMC 바로가기 [Article Type] Article