Multiplexed Magnetofluorescent Bioplatform for the Sensitive Detection of SARS-CoV-2 Viral RNA without Nucleic Acid Amplification핵산 증폭 없이 SARS-CoV-2 바이러스 RNA의 민감한 검출을 위한 다중 자기형광 바이오플랫폼Article Published on 2021-08-172022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료제, [키워드] acid Biotin clinical sample clinical samples complementary conditions COVID-19 pandemic death detect detection dynamic range fluorescent Genes genetic material gold gold standard help Hepatitis hepatitis C horseradish peroxidase linear loci magnetic bead Magnetic beads measles mitigate N genes Nasopharyngeal swab nasopharyngeal swabs Nile ORF1a outbreak Oxidation Patient patients peroxidase phenylenediamine point of care probe Rapid reached related virus reporter RNA RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 virus sensitive sensitivity Sensitivity and specificity subjects the SARS-CoV-2 total RNA Viral RNA viruses were used West [DOI] 10.1021/acs.analchem.1c01950 PMC 바로가기 [Article Type] Article
Proteomic Signature of Host Response to SARS-CoV-2 Infection in the Nasopharynx비인두에서 SARS-CoV-2 감염에 대한 숙주 반응의 단백질 서명Research Published on 2021-08-142022-09-10 Journal: Molecular & Cellular Proteomics : MCP [Category] 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition AGC, automatic gain control airway AKT Analysis antiviral property antiviral signaling asymptomatic infection caused CEP131 CFAP57 characterized ciliary component components confirmed COVID-19 case controls coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 severity COVID-19, Coronavirus disease 2019 CXCL10 downregulation dysregulated immune response dysregulation E3 ubiquitin ligases FDR, false discovery rate Health High-resolution host response humans IFN, interferon immune response implicated infected individual infected individuals Infection Inflammatory response interferon interferon-stimulated gene interferon-stimulated genes investigator investigators involved ISG15 ISGs, interferon-stimulated genes mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular MPB, mobile phase B multiorgan disease MX1 nasopharyngeal swabs negative control negative controls NHBE, normal human bronchial epithelial novel NP, nasopharyngeal OGFR, opioid growth factor receptor OPRPN, Opiorphin prepropeptide pandemic Pathogenesis pathogenesis of COVID-19 Pathways performed phosphoproteome Phosphoproteomics Phosphorylation PKC PPIase, peptidyl-prolyl cis/trans isomerase PRM, parallel reaction monitoring proteasomal Protein protein synthesis proteomic Proteomic analysis proteomics PRRs, pathogen-recognition receptors respiratory response RIG-I SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome Coronavirus shown signaling pathway signature Stat1 subunits Swab These data upper airway upregulated upregulation valuable resource Viral viral entry viral infection viral infections virus [DOI] 10.1016/j.mcpro.2021.100134 PMC 바로가기 [Article Type] Research
The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study급성 감염 단계를 넘어 긍정적 인 코리 바이러스/장 바이러스 검출 및 SARS-COV-2 지속성 : 하우스 내 감시 연구Communication Published on 2021-08-122022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI acute infection acute respiratory syndrome acute respiratory syndrome coronavirus adjusted odds ratio Adults association Barcelona Chain Reaction children Co-infection conducted Contact coronavirus COVID-19 cross-sectional detection ENhance enrolled enterovirus Epidemic epidemic wave family member first family household identify Infection transmission multiplex nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs nasopharynx persistence polymerase chain polymerase chain reaction Prolonged reported respiratory respiratory virus reverse transcription reverse transcription polymerase chain reaction rhinovirus RNA RT-PCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 RT-PCR significantly Spain tested time lag Viral viral respiratory [DOI] 10.3390/v13081598 PMC 바로가기 [Article Type] Communication
Integration of symptomatic, demographical and diet-related comorbidities data with SARS-CoV-2 antibody rapid diagnostic tests during epidemiological surveillance: a cross-sectional study in Jakarta, Indonesia역학 감시 중 SARS-CoV-2 항체 신속 진단 테스트와 증상, 인구 통계 및 식이 관련 동반 질환 데이터 통합: 인도네시아 자카르타의 횡단면 연구Article Published on 2021-08-102022-09-11 Journal: BMJ Open [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI addition age antibody Antigen assessment AUC Blood characteristic chest radiology collected Combination Community Comorbidities Comorbidity component conducted Contact costly cough COVID-19 cross-sectional cross-sectional study detect diabete diabetes diagnostic tests diarrhoea Dyspnoea epidemiological epidemiological surveillance Epidemiology Fever Gender group headache health workers hypertension IgG antibodies IgM/IgG IMPROVE Indonesia Infection infection rate infection rates infections integration investigated Jakarta Nasopharyngeal swab nasopharyngeal swabs Negative predictive value NPV outbreak PCR-confirmed Positive predictive value PPV Predictive Predictive value predictive values predictor predictors Principal component principal component analysis public health Rapid diagnostic test RDT RDTs receiver operating characteristic receiver operating characteristic curve reduced reverse transcription reverse transcription-PCR RT-PCR runny nose SARS-CoV-2 SARS-CoV-2 antibody sensitivity sore throat specificity Surveillance Symptom symptomatic symptomatic and asymptomatic Transmission utility venous venous blood virus detection with infection [DOI] 10.1136/bmjopen-2020-047763 PMC 바로가기 [Article Type] Article
DIA-Based Proteome Profiling of Nasopharyngeal Swabs from COVID-19 PatientsCOVID-19 환자의 비인두 면봉에 대한 DIA 기반 프로테옴 프로파일링Article Published on 2021-08-062022-09-11 Journal: Journal of Proteome Research [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] alteration Analysis animal model animal models approach best biological processe carried clinical sample clinical samples collected COVID-19 diaPASEF Diseases effort Evidence evidence of Exocytosis feasibility FIVE generate High-resolution Host Host immune response host response host response. infected cells innate immune response investigated knowledge mass spectrometer mechanism Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab specimens nasopharyngeal swabs nasopharynx outbreak pathway Pathways peptide peptides positive Profiling Protein proteome proteomic provided Quantitative RT-PCR testing SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection synthetic peptides upregulated Viral viral pathogenesis Viral protein was performed [DOI] 10.1021/acs.jproteome.1c00506 PMC 바로가기 [Article Type] Article
Dynamic profile of SARS-CoV-2 infection among hospitalized patients in Kuwait: a descriptive study쿠웨이트에서 입원 환자들 사이에서 SARS-COV-2 감염의 동적 프로파일 : 설명 연구Research Article Published on 2021-08-052022-09-10 Journal: BMC Infectious Diseases [Category] MERS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission age analyzed caused China Clinical characteristics collected Comorbidities conducted coronavirus COVID-19 demographic demographic and clinical characteristics disease dynamic extended viral shedding hospital Hospitalized hospitalized patient hospitalized patients information IQR knowledge Kuwait male median median age nasopharyngeal swabs older patients pandemic Patient patients patients with comorbidities PCR test positive real-time RT-PCR respiratory Result RT-PCR RT-PCR test SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 RT-PCR test severe acute respiratory syndrome Coronavirus Swab Symptom test result test results the median the patient time interval time intervals Viral viral shedding Wuhan [DOI] 10.1186/s12879-021-06504-x PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic VariantsResearch Article Published on 2021-08-042022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] Amino acid Analysis antibody applied cell tropism Characteristics collected Consensus consensus genome consensus sequences COVID-19 D614G domain Epidemic evaluate Evolution Evolution of SARS-CoV-2 feature functional Genes Genetic genetic diversity Genome Haplotype Host host range hosts immune system independent indicated information Intervention introduced mutant mutant spectrum Mutation Nasopharyngeal swab nasopharyngeal swabs Next-generation sequencing NGS nine Patient platform pool Population Positive selection predict predominant previous study produced provided Quasispecies quasispecy replications RNA RNA virus S2 domain SARS-CoV-2 selective sequence sequenced significantly lower spike gene spike glycoprotein sputum Sputum sample Stool Substitution suggested variant variants Variation variations [DOI] 10.1128/Spectrum.00261-21 PMC 바로가기 [Article Type] Research Article
Isolated generalized myoclonus immune-mediated by SARS-CoV-2: an illustrative videotaped caseSARS-CoV-2에 의한 면역 매개된 전신간대성 근간대성 근경련증: 예시적인 비디오 테이프 사례Case Reports Published on 2021-08-012022-09-11 Journal: Neurological Sciences [Category] MERS, SARS, 진단, 치료기술, [키워드] abnormality Admission Anosmia capture causal link chest CT scan clinical manifestation CNS confirmation COVID-19 COVID-19 infection CSF Diagnosis diagnostic generalized myoclonus hypoxic patients ICU IgM IgM and IgG immune Immune-mediated increasingly Infection Invasion Isolated medication Metabolic disorders movement Movement disorders Myoclonus Nasopharyngeal swab nasopharyngeal swabs Occurrence para positive predominant respiratory SARS-CoV-2 SARS-CoV-2 RNA detection Seroconversion serology steroid Steroids Symptom [DOI] 10.1007/s10072-021-05164-8 PMC 바로가기 [Article Type] Case Reports
Evaluation and comparison of conjunctival swab polymerase chain reaction results in SARS-CoV-2 patients with and without ocular manifestationsObservational Study Published on 2021-08-012022-10-05 Journal: Indian journal of ophthalmology [Category] SARS, 임상, [키워드] Admission age Comorbidity conducted conjunctival Conjunctival secretion Conjunctival secretions Control controls disease enrolled evaluate eye had no less manifestation Manifestations nasopharyngeal swabs ocular ocular manifestations Patient PCR polymerase chain positive potential risk prospective observational study RT PCR RT-PCR S-CoV-2 SAR SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 positive patient SARS-CoV-2 positive patients severity of COVID-19 significantly statistical statistical significance statistically significant Swab Symptom tested Transmission [DOI] 10.4103/ijo.IJO_587_21 PMC 바로가기 [Article Type] Observational Study
Dental calculus-a reservoir for detection of past SARS-CoV-2 infection치석-과거 SARS-CoV-2 감염 감지를 위한 저장소Article Published on 2021-08-012022-09-11 Journal: Clinical Oral Investigations [Category] SARS, 치료기술, [키워드] Abstract calculus COVID-19 dental Dental calculus nasopharyngeal swabs SARS-CoV-2 SARS-COV-2 infection Serological testing [DOI] 10.1007/s00784-021-04001-8 PMC 바로가기 [Article Type] Article