Quantitative SARS-CoV-2 Viral-Load Curves in Paired Saliva Samples and Nasal Swabs Inform Appropriate Respiratory Sampling Site and Analytical Test Sensitivity Required for Earliest Viral Detection쌍을 이루는 타액 샘플 및 비강 면봉의 정량적 SARS-CoV-2 바이러스 부하 곡선은 초기 바이러스 검출에 필요한 적절한 호흡기 샘플링 부위 및 분석 테스트 감도를 알려줍니다Epidemiology Published on 2021-12-152022-09-10 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] analytical sensitivity Appropriate assays Asymptomatic case-ascertained Concentration conducted COVID-19 Critical Curve detect detectable detection diagnosed with COVID-19 diagnostic diagnostic sensitivities diagnostics Early detection Efficacy greater household contact household study incidence individual Infection infections longitudinal sampling Los Angele Los Angeles nasal swab nasal swabs pandemic Pandemics Participants presymptomatic presymptomatic transmission profile quantification quantitative PCR reached reduce respiratory respond RT-qPCR Saliva saliva samples Sample sampling SARS-CoV-2 SARS-COV-2 infection sensitivity Seven Site Spread Stage Surveillance symptomatic Test Transmission Treatment undetectable variant variants Viral Viral load viral loads [DOI] 10.1128/jcm.01785-21 PMC 바로가기 [Article Type] Epidemiology
sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 ActivitySTREM-1은 COVID-19 환자의 질병 중증도 및 사망률을 예측합니다 : 말초 혈액 백혈구 및 MMP-8 활동의 관여Article Published on 2021-12-152022-08-31 Journal: Viruses [Category] SARS, 바이오마커, [키워드] activity Biomarker Characteristics clinical Clinical data coronavirus coronavirus disease correlated COVID-19 COVID-19 positive patient Critical death disease enrolled evaluated expressed expression groups IL-10 IL-6 IL-8 immunoassays indicated Inflammation inflammatory mediator inflammatory parameters Inflammatory response inflammatory signals intrinsic investigated Involvement lymphocyte lymphocyte counts matrix metalloproteinase matrix metalloproteinases mediator medical records Mild MMP-8 moderate Mortality MOST myeloid cells myeloid cells-1 neutrophil neutrophil counts outcome Patient patients with COVID-19 peripheral Peripheral blood peripheral blood cells pharmacological intervention pharmacological interventions plasma Plasma level Plasma levels positive correlation positive patients Predictive profile quantification severe disease severity severity of COVID-19 significant negative correlation significantly significantly higher sTREM-1 systemic the timing uncontrolled was related [DOI] 10.3390/v13122521 PMC 바로가기 [Article Type] Article
Droplet digital RT-PCR to detect SARS-CoV-2 signature mutations of variants of concern in wastewater폐수에서 우려되는 변이체의 SARS-CoV-2 서명 돌연변이를 감지하는 물방울 디지털 RT-PCRArticle Published on 2021-12-102022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, 치료기술, [키워드] aligned allocation antibody B.1.1.7 B.1.351 can be used causative agent Community coronavirus COVID-19 demonstrated detect detection determine droplet E484K indicate information K417N L452R limit Lineage measure MONITOR monitoring Mutation mutation N501Y N501Y N501Y mutation Netherlands Occurrence proportion Public public health quantification RNA RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants sewage Sewage surveillance shown Spread Support Surveillance Transmissibility Type vaccination variant variants variants of concern viral spread VoC wastewater [DOI] 10.1016/j.scitotenv.2021.149456 PMC 바로가기 [Article Type] Article
Automated quantification of COVID-19 pneumonia severity in chest CT using histogram-based multi-level thresholding segmentationResearch Published on 2021-12-092022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] automated Chest CT Clinical severity Computed tomography computed tomography (CT) consolidation correlated correlation COVID-19 COVID-19 pneumonia patients Critical CT scan enrolled fatal disease Follow-up GGOs ground-glass opacity high correlation Histogram-based Intubated intubation lung Lung CT lung lesion Lungs Metrics Mild moderate Oxygenation Patient percentage performed Pneumonia quantification Quantification method Quantitative analysis quantitative assessment Quantitative imaging Radiologists Result Retrospective study risk stratification semi-quantitative severity severity scoring Spearman’s correlation Support the disease the patient two group volumetric was used [DOI] 10.1186/s43055-021-00602-1 PMC 바로가기 [Article Type] Research
An age-structured SEIR model for COVID-19 incidence in Dublin, Ireland with framework for evaluating health intervention cost건강 중재 비용 평가를위한 프레임 워크와 함께 아일랜드 더블린에서 Covid-19 발병에 대한 연령 구조화 된 SEIR 모델Research Article Published on 2021-12-072022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, [키워드] adopted age approach assist association available data characterising Cohort Community Contact COVID-19 incidence described disease flexible form group groups Health in some incidence rate incidence rates Interaction interactions Intervention involved Ireland lockdown measure mental health mitigate morbidity outcome Predictive quantification Region retrospective SEIR Spread Strategy Uncertainty variant [DOI] 10.1371/journal.pone.0260632 PMC 바로가기 [Article Type] Research Article
A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocolObservational Study Published on 2021-12-022022-10-04 Journal: BMC Infectious Diseases [Category] SARS, 임상, [키워드] analysed Analysis Antimicrobial therapy approach Bacterial infection biochemical bioinformatic processing blood sample change clinician COVID-19 COVID-19 patients Critical care Critically ill patient data set diagnose diagnosing Diagnosis diagnostic disease Evidence faster hospitals increased mortality increased risk Infection metabolite metabolomics microorganism Patient patients quantification recruited Sample Scottish secondary bacterial infection Secondary bacterial infections Secondary infection secondary infections specific biomarkers statistical analysis Study protocol with COVID-19 [DOI] 10.1186/s12879-021-06832-y PMC 바로가기 [Article Type] Observational Study
An open-label randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19코로나19로 입원한 환자를 대상으로 한 로피나비르/리토나비르, 로피나비르/리토나비르 + IFN-β-1a 및 히드록시클로로퀸의 효과에 대한 공개 무작위 대조 시험Clinical Trial Published on 2021-12-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] 임상, 치료제, [키워드] 95% confidence interval 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive adjusted odds ratio adults hospitalized age analyses Arm ARMS clinical status conducted Controlled trial coronavirus coronavirus 2019 disease COVID-19 evaluated expected hospitalized patient Hydroxychloroquine Inpatient intention-to-treat population Interferon β-1a IQR Lopinavir LOPINAVIR AND RITONAVIR Lopinavir/ritonavir male median age multicentre no significant effect not improved Occurrence Open-label Ordinal Scale outcome oxygen participant pharmacokinetic plasma concentration Primary outcome quantification Randomized Randomized controlled trial regimen Remdesivir respiratory specimen respiratory specimens respiratory tract specimens Ritonavir SARS-CoV-2 SARS-CoV-2 clearance secondary Secondary outcomes Serious Adverse Event Serious Adverse Events seven-point ordinal scale severe acute respiratory syndrome Coronavirus severe disease significant effect significantly higher solidarity Solidarity trial Standard of care the median the WHO treat Treatment Trial trough ventilatory support Virological with COVID-19 [DOI] 10.1016/j.cmi.2021.05.020 PMC 바로가기 [Article Type] Clinical Trial
REGEN-COV ® antibody cocktail bioanalytical strategy: comparison of LC-MRM-MS and immunoassay methods for drug quantificationREGEN-COV ® 항체 칵테일 생물분석 전략: 약물 정량을 위한 LC-MRM-MS 및 면역분석 방법의 비교Comparative Study Published on 2021-12-012022-09-12 Journal: Bioanalysis [Category] MERS, SARS, 진단, [키워드] addition Analysis anti-SARS-CoV-2 antibody cocktail bioanalytical Bland-Altman Concentration correlation COVID-19 COVID-19 pandemic Critical dose drug drug concentration assay ECL immunoassay Initially linear monoclonal antibody monoclonal antibody therapeutic. parameters pharmacokinetic data produced profile public health emergency quantification REGEN-COV Regeneron Result SARS-CoV-2 supported targeted therapy therapeutic therapy USA was performed was used [DOI] 10.4155/bio-2021-0190 PMC 바로가기 [Article Type] Comparative Study
A review on detection of SARS-CoV-2 RNA in wastewater in light of the current knowledge of treatment process for removal of viral fragments바이러스 단편 제거 처리 공정에 대한 최신 지식에 비추어 폐수 내 SARS-CoV-2 RNA 검출에 대한 검토Review Published on 2021-12-012022-09-11 Journal: Journal of environmental management [Category] SARS, 치료기술, [키워드] 2019-nCoV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Analysis Chain Reaction Community Concentration condition coronavirus Coronavirus 2019 COVID-19 COVID-19 pandemic dependent on discharge disease Disinfection efficient eliminating environmental factor environmental factors Epidemiology global pandemic globe glycol implication include knowledge membrane MOST National outbreak pathogen Pathogens Polyethylene glycol polymerase chain reaction quantification Quantitative quantitative reverse transcription-polymerase chain reaction reduce regions removal reported RNA route RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus Spread Surface water Surveillance the SARS-CoV-2 to be done Transmission transmission of SARS-CoV-2 Transmission routes Treatment ultracentrifugation Ultrafiltration Untreated wastewater Viral concentration viral concentrations viral fragment virus Virus concentration method wastewater Wastewater treatment process Wastewater–based epidemiology (WBE). water water bodies WHO World Health Organisation Worry [DOI] 10.1016/j.jenvman.2021.113563 PMC 바로가기 [Article Type] Review
RT-qPCR assays for SARS-CoV-2 variants of concern in wastewater reveals compromised vaccination-induced immunity폐수에서 우려되는 SARS-CoV-2 변이체에 대한 RT-qPCR 분석은 손상된 백신 유도 면역을 나타냅니다Article Published on 2021-12-012022-09-11 Journal: Water research [Category] SARS, 변종, 치료기술, [키워드] Alpha variant appearance Beta booster Chain Reaction Community continuous monitoring correlated COVID-19 COVID-19 vaccine D614G decrease delta variant dominance dose Effectiveness Efficiency effort epidemiological Epidemiology Factor fluctuation Gamma Immunity increase in infection rate morbidity neutralization original outbreak pandemic Pfizer-BioNTech polymerase chain polymerase chain reaction Prevalence quantification Quantitative reveal reverse transcriptase Reverse transcriptase quantitative polymerase chain reaction RT-qPCR RT-qPCR assay RT-qPCR assays SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus SARS-CoV-2 viruses sensitive subsequent Surveillance vaccination vaccination rate Vaccinations Vaccine variant variants variants of concern virus Wastewater-based epidemiological. [DOI] 10.1016/j.watres.2021.117808 PMC 바로가기 [Article Type] Article