Altered Gut Microbiota Profiles in Sows and Neonatal Piglets Associated with Porcine Epidemic Diarrhea Virus InfectionArticle Published on 2017-12-122022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Altered Asymptomatic Bacteria Bacteroidete caused demonstrated diarrhea diarrheal dominant epidemic diarrhea examined Firmicute Fusobacteria gut microbiota healthy Illumina Miseq Infection less molecular MOST pathogenic pathogenic bacteria PEDV Perturbation platform probiotic bacteria profile Proteobacteria reduced replaced significant decrease the healthy virus [DOI] 10.1038/s41598-017-17830-z PMC 바로가기 [Article Type] Article
Receptor-binding loops in alphacoronavirus adaptation and evolutionArticle Published on 2017-11-232022-10-29 Journal: Nature Communications [Category] Coronavirus, MERS, [키워드] accompanied aminopeptidase N Analysis APN buffer characterized complex coronavirus ectodomain Evolution extended loop HCoV-229E high mutation rate IMPROVE interactions Mutation neutralizing antibody random RBD receptor Receptor binding replaced responsible RNA virus the mean the RBD the receptor-binding domain Variation viral fitness virus X-ray [DOI] 10.1038/s41467-017-01706-x PMC 바로가기 [Article Type] Article
A reverse genetics system for avian coronavirus infectious bronchitis virus based on targeted RNA recombinationResearch Published on 2017-06-122022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Accessory genes avian coronavirus cause Cell cell lines cells Characteristics chicken chimeric co-transfected coding Complete coronavirus ectodomain Embryonated eggs generate genetics Genome genomic growth IBV in vivo infect Infectious Bronchitis Virus isolates Major marker MHV Modification Molecular biology mouse hepatitis virus murine mutations parental poultry recombinant Recombination replaced respiratory pathogen Result Reverse genetics system RNA RNA recombination specific mutation spike gene spike glycoprotein strain Strains supplementary material synonymous Targeted RNA recombination Vaccine Vaccine development virulent virus was performed was used wild-type [DOI] 10.1186/s12985-017-0775-8 PMC 바로가기 [Article Type] Research
In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated ProteinsResearch Article Published on 2017-01-312022-10-29 Journal: mBio [Category] Coronavirus, [키워드] association biochemical carried complexes conserved coronavirus Coronavirus infection Coronaviruses CoV CoV infection CoV protein CoV replication defined determine domain Endoplasmic reticulum enzymatic activity enzyme epitope function genomic RNA help independent Infection interact Interaction interactions involved knowledge membrane MHV mouse hepatitis virus nonstructural protein not affect Nsp12 Nsp15 Nsps P/S polymerase Protein replaced Replication replication complex replicative required RNA RTC Tagged Transcription Viral protein viral replication virus virus replication while [DOI] 10.1128/mBio.02320-16 PMC 바로가기 [Article Type] Research Article
Dynamically-Driven Enhancement of the Catalytic Machinery of the SARS 3C-Like Protease by the S284-T285-I286/A Mutations on the Extra DomainResearch Article Published on 2014-07-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 3CL 3CLpro Ala Alter appear catalytic catalytic dyad component conducted correlated correlation Correlation analysis Critical dimeric disrupting domain domains Effects ENhance enhancement enzyme inactivated inactive include mechanisms molecular MOST mutant Mutation opposite Perturbation protease reduction replaced reported residue residues resulting reveal significantly specific inhibitor stability Trigger Volume while wild-type [DOI] 10.1371/journal.pone.0101941 PMC 바로가기 [Article Type] Research Article
Infectious Bronchitis Virus as a Vector for the Expression of Heterologous GenesResearch Article Published on 2013-06-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] analysed assays avian coronavirus bronchitis cells chick compared demonstrated eGFP expressed expressing expression fluorescence microscopy fluorescent Gene generate Genetic genetics Genome Heterologous IBV increase in Infection infectious Infectious Bronchitis Virus intergenic region kidney luciferase activity MOI offer ORF Pathogens Protein recombinant Renilla luciferase replaced replacing reporter reporter gene rescued Respiratory disease stability utilised vaccination Vaccine vector [DOI] 10.1371/journal.pone.0067875 PMC 바로가기 [Article Type] Research Article
Arabidopsis thaliana RESISTANCE TO FUSARIUM OXYSPORUM 2 Implicates Tyrosine-Sulfated Peptide Signaling in Susceptibility and Resistance to Root InfectionArabidopsis thaliana FUSARIUM OXYSPORUM 2에 대한 내성은 뿌리 감염에 대한 감수성과 내성에 티로신-황산염 신호 전달을 의미합니다Research Article Published on 2013-05-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting Affect Arabidopsis thaliana Diversity downregulate effector explain expression Extracellular Fusarium Gene Genes host immunity induce Infection inhibit lethal leucine loci locus mutant mutants negative feedback pathogen-specific peptide plant promote Protein provide QTLs Quantitative receptor Regulation related relative susceptibility replaced resistance root Signaling Support suppresse susceptibility traits transgenic tyrosine Vascular while [DOI] 10.1371/journal.pgen.1003525 PMC 바로가기 [Article Type] Research Article
Residue analysis of a CTL epitope of SARS-CoV spike protein by IFN-gamma production and bioinformatics predictionResearch Article Published on 2012-09-102022-10-28 Journal: BMC Immunology [Category] Coronavirus, Fulltext, MERS, [키워드] acute respiratory syndrome Alanine Analysis ANN antigenic epitopes ARB binding bioinformatics caused cells CTL CTL epitope demonstrated DNA electrostatic ELISA epitope exaggerate FACS functional hydrophobic IFN-gamma immunized mice induce Infectious disease Interaction lysine mutant mutated Novel coronavirus peptide peptides predicted replaced reported residue Result S protein SARS CoV SARS-CoV SARS-CoV S SARS-CoV spike protein severe Spike protein splenocyte steric T cell epitope TCR the binding affinity the mean was used [DOI] 10.1186/1471-2172-13-50 PMC 바로가기 [Article Type] Research Article
MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic StressMK2-의존성 p38b 신호는 만성 스트레스 하에서 JNK 유도 세포자멸사로부터 Drosophila Hindgut Enterocytes를 보호합니다Research Article Published on 2011-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addressed affected antimicrobial peptides Apoptosis atrophy Author branch cascade Cell chronic complex component contribute damage damaged descendants Deterioration Diseases Drosophila Elimination Enterocyte enterocytes epithelial epithelium event form genetic analysis Gut Hindgut homeostasis Impaired induce integrity intestinal Intestinal diseases intestinal epithelium intestinal stem cell Intestinal stem cells JNK kinases leads less manifested pathogen Pathogens pathway peptides peptides) Prevent proliferation PROTECT Protective Protein protein kinase replaced REPLACED BY Replenishment required salt Signal transduction stem cell stem cells Stress Stressor stressors subsequent suppresse Trigger triggers upregulated upstream [DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article
The Replicase Gene of Avian Coronavirus Infectious Bronchitis Virus Is a Determinant of PathogenicityResearch Article Published on 2009-10-092022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accessory gene avirulent cell tropism Complete demonstrated determinant dominant Genome IBV in vitro Infectious Bronchitis Virus M41 pathogenicity replaced replicase S gene virulence virulent virus [DOI] 10.1371/journal.pone.0007384 PMC 바로가기 [Article Type] Research Article