Ulcerative Colitis: Current and Emerging Treatment StrategiesReview Published on 2019-12-302024-09-02 Journal: Journal of Clinical Medicine [Category] 대상포진, [키워드] biologic colectomy small molecule ulcerative colitis [DOI] 10.3390/jcm9010094 PMC 바로가기 [Article Type] Review
Novel Small Molecule Targeting the Hemagglutinin Stalk of Influenza VirusesArticle Published on 2019-08-132023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] Antiviral agents hemagglutinin stalk Influenza virus membrane fusion small molecule [DOI] 10.1128/JVI.00878-19 PMC 바로가기
The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signalsCspC pseudoprotease는 여러 환경 신호에 대한 응답으로 Clostridioides difficile 포자의 발아를 조절합니다Research Article Published on 2019-07-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Alter Amino acid Bacteria bile acid bile acids calcium Clostridioide Clostridioides conserved Critical crystal structure detect dormant exhibited function germination Gut hypo induce Infection initiate involved lack mammalian mechanism mechanism of action Mutation nosocomial Organisms pathogen physically question raise receptor regulate residue sensitivity Signaling small molecule Small molecules spore thought transmembrane unique variant while [DOI] 10.1371/journal.pgen.1008224 PMC 바로가기 [Article Type] Research Article
The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C . elegans핵 호르몬 수용체 NHR-86은 C에서 항병원체 반응을 조절한다. 엘레강스Research Article Published on 2019-01-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation adaptive Analysis Author bacterial pathogen baseline bind biological function canonical characterized chromatin chromatin immunoprecipitation Control determine Drosophila effector elegan elegans exogenous ligands experiments family function Genetic genetic screen Genome homolog hormone receptor hormone receptors host response Human immune immune activation immunostimulatory induce Infection innate immune activation majority MAPK modulate nuclear pathogen pathway PMK-1 positioned promoter promoters Protective Protein provide Pseudomonas aeruginosa Recognition Regulation required response small molecule target Transcription transcription factor transcription factors transcriptional transcriptional regulator transcriptional response Transcriptome [DOI] 10.1371/journal.pgen.1007935 PMC 바로가기 [Article Type] Research Article
Crystal structure of the post‐fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolutionResearch Papers Published on 2018-09-102022-10-27 Journal: Acta crystallographica. Section D [Category] Coronavirus, MERS, [키워드] addition Adults appear cause comparison Complete conserved coronavirus coronavirus 229E crystal structure electrostatic electrostatic interaction facilitate HCoV‐229E heptad repeat host cell host membranes Human human coronavirus hydrophobic hydrophobic interaction immune systems individual inhibit inhibitor Interaction involved MERS Mild Mortality opposite peptide polar post‐fusion core preserved Protein representing reveal S1 domain S2 domain SARS severe complication small molecule Spike protein structures subsequent surface potential upper respiratory infection virus was determined weakened X‐ray structure [DOI] 10.1107/S2059798318008318 PMC 바로가기 [Article Type] Research Papers
Innovation and trends in the development and approval of antiviral medicines: 1987-2017 and beyondReview Published on 2018-07-012023-06-18 Journal: Antiviral Research [Category] B형 간염, Fulltext, [키워드] Antiviral Chronic viral infection Direct acting agent respiratory virus small molecule [DOI] 10.1016/j.antiviral.2018.05.005 PMC 바로가기 [Article Type] Review
A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis2단계 수송 경로를 통해 모세포가 Bacillus subtilis에서 발달 중인 포자를 양육할 수 있습니다.Research Article Published on 2017-09-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accumulation Bacillus anthracis Bacillus subtilis Bacteria Bacterial Cell Clostridium difficile complex Concentration conserved Culture culture medium dehydration desiccation dipicolinic acid displace dormancy dormant dry weight engulfment enzyme Enzymes Evidence Express Factor forespore hallmark hallmarks homolog homologs idea late stage mechanism medium membrane membranes molecular basis Morphological mother mother cell Mutagenesis non-pathogenic bacteria nucleoside pathogenic pathway predicted produced Protective Protein pyridine-2,6-dicarboxylic acid remained required residue residues small molecule spore spore core spores sporulation Support translocated Transport vegetative growth water [DOI] 10.1371/journal.pgen.1007015 PMC 바로가기 [Article Type] Research Article
Janus kinase antagonists and other novel small molecules for the treatment of Crohn’s diseaseArticle Published on 2017-05-182024-09-04 Journal: Gastroenterol Clin North Am : book_id PMC인데 pubmed로 기재 [Category] 대상포진, [키워드] Crohn’s disease filgotinib JAK inhibitor mongersen Ozanimod SMAD7 small molecule sphingosine-1-phosphate receptor TGF-β [DOI] 10.1016/j.gtc.2017.05.015 PMC 바로가기 [Article Type] Article
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans인간 진균 병원체 크립토코커스 네오포르만스에서 칼시뉴린-Crz1 스트레스 반응 전사 네트워크의 해명Research Article Published on 2017-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated appear ascomycete ascomycetes Aspergillus fumigatus binding calcineurin calcium calmodulin Candida albican Candida albicans cascade Cell cell wall cellular cna1 conserved contribute Control Cryptococcus neoforman Cryptococcus neoformans docking domain down-regulated downstream Evidence expression of gene Factor function functions fungal fungal pathogen fungal pathogens fungi high temperature involved majority motif mRNA mRNA expression mutant mutants nuclear translocation nucleus P-bodies P-body pathogen pathogenic Pathogens pathway phenotype Phenotypes pheromone phosphatase post-transcriptional levels predicted promote promoter promoter region promoter regions Protein regulate regulated regulatory network responses RNA-sequencing Saccharomyces cerevisiae Serine Signal transduction Signaling small molecule Stress stress granule stress granules stress response survival target target gene Target genes targets threonine Transcription transcription factor transcriptional Transport virulence wild-type [DOI] 10.1371/journal.pgen.1006667 PMC 바로가기 [Article Type] Research Article
Malpighian Tubules as Novel Targets for Mosquito Control말피기관을 모기 퇴치의 새로운 표적으로 삼기Review Published on 2017-01-242024-08-12 Journal: International Journal of Environmental Research and Public Health [Category] 말라리아, [키워드] detoxification homeostasis insecticides Malpighian tubules mosquito, Kir channels small molecule [DOI] 10.3390/ijerph14020111 PMC 바로가기 [Article Type] Review