Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked PolyubiquitinationImmunology Published on 2019-05-092022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] Activation antiviral response binding coronavirus demonstrated diarrhea double-stranded RNA Host host antiviral response IFN-β IFN-β immune Infection infections inhibit inhibiting innate immune response interfere interferon mechanism N protein N-terminal Newborn nucleocapsid nucleocapsid protein outbreak PDCoV porcine RIG-I Production promoter Protein receptor RIG-I signaling molecules stimulated suppressed Surveillance therapeutic target TNF ubiquitination Vaccine vesicular stomatitis virus virus infection Virus-host interaction vomiting VSV [DOI] 10.3389/fimmu.2019.01024 PMC 바로가기 [Article Type] Immunology
Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling PigletsImmunology Published on 2019-04-242022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] acute diarrhea Affect affected antibody antibody secreting cell ASC B cells cause change circulating Control correlated Course Critical Cytokines determine during pregnancy epidemic diarrhea example gestation gut-mammary-secretory IgA axis IgA IgG immature immune system immune parameter immune protection immune response Immunity Impact implication Infection influence inoculated intestinal lactogenic Lactogenic immunity lymphocyte Maternal medium mucosal naïve Neonatal Neonate Neutralizing PEDV positively correlated Pregnancy pregnant protection required response resulting serum significantly significantly higher Stage stimulate stimulated subsequent Suckling survival survival rate swine three group Vaccines viral infections virulence virus [DOI] 10.3389/fimmu.2019.00727 PMC 바로가기 [Article Type] Immunology
Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitisArticle Published on 2019-01-082022-11-01 Journal: Cell Death & Disease [Category] Coronavirus, [키워드] administration Affect anti-viral response Apoptosis death demonstrated Depletion described double-stranded RNA early stage exacerbate fulminant viral hepatitis Genotype HBV HBV infection Hepatitis Hepatitis B virus hepatocyte homozygous infected patients labeling Liver damage liver parenchymal cell liver tissue Macrophage mice mimicking murine murine hepatitis virus Mutation pathogen-associated molecular polymorphism Prevent primary culture PROTECT Protein RIPK1 risk secreted severe symptom signaling pathway stimulated syndrome TNF-α to define transaminase triggered wild-type worsening [DOI] 10.1038/s41419-018-1277-3 PMC 바로가기 [Article Type] Article
Oral administration of inactivated porcine epidemic diarrhea virus activate DCs in porcine Peyer’s patchesResearch Article Published on 2018-08-162022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] activate adaptive administration Allogeneic antibody Antigen Cell contagious DCs dendritic cell dendritic cells epidemic diarrhea Gut IgA IgG antibody IL-1 IL-4 immune immune response Immunity inactivated Inactivated porcine epidemic diarrhea virus Interaction intestinal intestine investigated Lymphocytes mucosal oral administration PEDV Peyer’s patche Peyer’s patches proliferation reported Result Safe secreted cytokine serum SIgA significantly increased stimulated Vaccine viral disease virus [DOI] 10.1186/s12917-018-1568-z PMC 바로가기 [Article Type] Research Article
Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation글루코사민은 Crz1 핵 전위를 촉진하여 Cryptococcus neoformans에서 페로몬 독립적인 이형 전이를 자극합니다Research Article Published on 2017-09-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Antifungal antifungal therapy attenuate calcineurin caused Cell cellular response clinically complex component Cryptococcal cells cryptococcal meningitis cryptococcosis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoplasm demonstrated disease downstream effector effectors elicited fertile fungal Genetic genetic screen glucosamine glycerol Host Host immune response host immune responses hosts identity immune responses immune-stimulatory independent independent of Interaction isolate limitations majority mammalian MAPK Meningitis morphogenesis Morphological morphological change Morphotype nuclear translocation nucleus Pathogenesis pathway pheromone phosphatase promote promoted PROTECT raise recent reference strain responsible serotype shown signaling pathway stimulate stimulated strain Stress stress response subsequent suppressed switching transcription factor translocation Trigger undergo Vaccine Vaccine development virulence virulent yeast [DOI] 10.1371/journal.pgen.1006982 PMC 바로가기 [Article Type] Research Article
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variantsResearch Article Published on 2017-05-182022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Antiviral Antiviral agents antiviral drug antiviral strategy applied approach binding blocked catalytic catalytic activity cellular cleaving complicate component Critical develop domain DUB Ebola effective enzyme Enzymes expression Health Hemorrhagic fever virus high affinity Host humans identify infect infected patient Infection prevention inhibit inhibited inhibitor inhibitors innate immune responses interferon ISG15 magnitude MERS-CoV MERS-CoV infection Middle East molecular interaction mRNA outbreak Outbreaks Papain-like protease pathogenic virus pathogenicity plants polyprotein potent progeny PROTECT Protein Protein design provide reduced Replication replicative respiratory syndrome coronavirus responsible selective similarity specificity stimulated suppress targets therapeutic therapy transgenic Treatment variant variety viral pathogen viral replicase polyprotein viral replication virus viruses while Zika virus [DOI] 10.1371/journal.ppat.1006372 PMC 바로가기 [Article Type] Research Article
Immunological aspects of the efficiency of protectotype vaccination strategy against chicken infectious bronchitisResearch Article Published on 2017-02-082022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] applied benefit bronchitis CD8 Cell-mediated immunity chicken CMI cross-reactivity demonstrated Efficiency generate humoral Humoral immunity IB IBV IgA immune system Immunity Infection investigated Protectotype vaccination strategy protocol reflect Result serum spleen stimulate stimulated strain Strains T cell upper respiratory tract URT vaccination Vaccination strategy Vaccine [DOI] 10.1186/s12917-017-0963-1 PMC 바로가기 [Article Type] Research Article
SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathwayArticle Published on 2016-05-132022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] A549 cells Activation Analysis binding site dependent activation dose epithelial cell expression Genes human lung in vitro in vivo indicated induce inhibitor injection luciferase reporter assay lung lung tissues Macrophage infiltration MAPK mechanism Mouse models NF-κB nuclear translocation Papain-like protease pathway Plasmid PLPro pro-fibrotic promoter promoter region reduced response responsible ROS SARS Coronavirus SARS-CoV significantly siRNA STAT3 stimulated TGF-β1 transcription factor triggered triggering up-regulate up-regulating vimentin [DOI] 10.1038/srep25754 PMC 바로가기 [Article Type] Article
A general strategy to inhibiting viral −1 frameshifting based on upstream attenuation duplex formationMolecular Biology Published on 2016-01-082022-10-31 Journal: Nucleic Acids Research [Category] Coronavirus, [키워드] annealing antiviral target approach attenuate combating complementary coronavirus Coronaviruses downregulate downstream efficient Epidemic eukaryotic HIV Human immunodeficiency virus indicate information inhibiting mechanism MERS-CoV Middle East mRNA provide proximal respiratory syndrome coronavirus responsible RNA robust sequence sequence information shown stimulated upstream viral pathogen viral pathogens [DOI] 10.1093/nar/gkv1307 PMC 바로가기 [Article Type] Molecular Biology
Heterologous Aggregates Promote De Novo Prion Appearance via More than One Mechanism이종 골재는 하나 이상의 메커니즘을 통해 De Novo Prion 모양을 촉진합니다.Research Article Published on 2015-01-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence aggregate aggregates aggregation appear appearance asparagine Cell cells cellular chaperone characteristic Colocalization conformational cytoplasm de novo detect disease domains eukaryotic form Glutamine Heterologous Interaction lack mechanisms molecular MOST neurodegenerative no interaction open overexpressed overexpression pathway periphery phenotypic phenotypic traits physical Polymer prevalent prion promote Protein Proteins PSI required seed stimulated the cell traits vacuole variant while yeast [DOI] 10.1371/journal.pgen.1004814 PMC 바로가기 [Article Type] Research Article