Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern Research Published on 2022-06-092022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] affected antibody B-cell Beta binding CD4+ T cell CD8+ T cell cellular central memory characterized comparable declined Delta Efficacy elicit exhibited follicular help humoral immune memory Inactivated vaccine individuals induce Infection magnitude memory B cell memory response persist persistence populations post vaccination produced pseudovirus neutralizing antibody reduction in robust SARS-CoV-2 T helper cell the vaccine vaccinated individuals vaccination Vaccine variant variants variants of concern [DOI] 10.1038/s41564-022-01161-5 [Article Type] Research
Effectiveness of BBIBP-CorV vaccine against severe outcomes of COVID-19 in Abu Dhabi, United Arab Emirates Research Published on 2022-06-092022-10-05 Journal: Nature Communications [Category] 임상, 치료법, [키워드] 1:1 95% CI Abu Admission Adults age Analysis BBIBP-CorV booster dose characterized coefficient Comorbidity conducted COVID-19 Critical care death declined Effectiveness Electronic health record General population Hospitalization inactivated outcome outcomes retrospective cohort study severe COVID-19 Sex the vaccine United Arab Emirate vaccinated individual Vaccine was used [DOI] 10.1038/s41467-022-30835-1 [Article Type] Research
Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccinesClinical and Translational Report Published on 2022-06-092022-10-04 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] Abstract Affect Analysis Animal experiment antibody antibody cross-reactivity antibody response against association B.1.617.2 Booster vaccine breadth China circulating clinical evidence clinical observation Cohort Commission conducted confounders Context cost-efficient strategy COVID-19 vaccination COVID-19 vaccine Department development elicit Evidence finding foundation funding Health care worker healthcare worker Heterologous heterologous prime-boost heterologous vaccination heterologous vaccine homologous homologous or heterologous immune responses immunological analysis inactivated Influenza Innovation International Laboratory test mechanism Multivariable regression natural Neutralization antibody neutralization titer Neutralizing Neutralizing activity physician PNA Program protective immunity Pseudovirus neutralization assay recipient SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Science Serum Neutralization Shenzhen shown significantly lower subsequent suggested technology the United State the vaccine vaccination vaccination schedule Vaccine Vaccines variant variants veteran Virus neutralization Wuhan-Hu-1 [DOI] 10.1016/j.medj.2022.05.003 PMC 바로가기 [Article Type] Clinical and Translational Report
Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trialRandomized Controlled Trial Published on 2022-06-092022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 진단, [키워드] 95% CI addition Adjusted analysis anti-SARS-CoV-2 anti-Spike IgG Antibody Response assigned AstraZeneca baseline benefit BNT162b2 booster Cellular immune response ChAdOx1 ChAdOx1 nCoV-19 Cohort COVID-19 vaccine dose Effect eight EudraCT Evidence Exploratory analyses Exploratory analysis finding funding Future geometric mean concentration geometric mean ratio group groups Heterologous heterologous vaccine homologous humoral humoral immunogenicity immune persistence immune response immunogenic immunogenicity analysis Immunological response intention-to-treat interval intervals ISRCTN ITT ITT analysis less Older participant persistence Pfizer/BioNTech platform priming randomised Randomly reactogenic reactogenicity reduced Registered SARS-COV-2 infection second dose significant difference significantly higher spike IgG study groups Support T-cell Response the vaccine titre Trial Vaccine Virus neutralisation [DOI] 10.1016/S2213-2600(22)00163-1 [Article Type] Randomized Controlled Trial
Study protocol: cohort event monitoring for safety signal detection after vaccination with COVID-19 vaccines in Iran연구 프로토콜: 이란에서 COVID-19 백신 접종 후 안전 신호 감지를 위한 코호트 이벤트 모니터링Article Published on 2022-06-092022-09-11 Journal: BMC Public Health [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] approved articles AZD1222 BBIBP-CorV clinical trial clinical trials Cohort Cohort profile Complete continuous monitoring COVID-19 COVID-19 disease COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines Data collection dose enrolled expansion follow-up period Health Organization Hospitalization implementation include investigated Iran National New Other outcome participant prospective cohort study protocol provided reactogenicity receive required Safety second dose Seven Sinopharm study outcome study outcomes Surveillance target population Template the vaccine vaccination Vaccine Vaccines WHO with COVID-19 World Health Organization [DOI] 10.1186/s12889-022-13575-1 PMC 바로가기 [Article Type] Article
Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine재조합 식물 기반 면역증강제 코로나19 백신의 효능 및 안전성Clinical Trial Published on 2022-06-022022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adverse event age Analysis AS03 assigned baseline candidate vaccine caused conducted coronavirus coronavirus disease Coronavirus disease 2019 CoVLP CoVLP+AS03 determine disease dose effective Efficacy Factor FIVE incidence injection intention-to-treat intention-to-treat population Intramuscular injection Local median age Median viral load Medicago Mild moderate occurred participant Participants participated Particle performed Phase 3 Placebo placebo group placebo-controlled trial plant plants polymerase post-hoc analysis prefusion produced Randomized receive recombinant respiratory Safety SARS-CoV-2 sequenced Sequencing seronegative severe acute respiratory syndrome Coronavirus Severe case Spectrum spike glycoprotein symptomatic symptomatic COVID-19 symptomatic infection System systemic adverse event systemic adverse events the median the placebo group the vaccine Trial two group two groups Vaccine vaccine efficacy vaccine group variant variants Viral Viral load viral sample Volunteer [DOI] 10.1056/NEJMoa2201300 PMC 바로가기 [Article Type] Clinical Trial
Acute cardiac side effects after COVID-19 mRNA vaccination: a case seriesCOVID-19 mRNA 백신 접종 후 급성 심장 부작용: 사례 시리즈Case Reports Published on 2022-06-022022-09-11 Journal: European Journal of Medical Research [Category] COVID19(2023년), SARS, 변종, [키워드] affecting age analyzed approval Asymptomatic BNT162b2 cardiac adverse event cardiac adverse events Cardiac arrhythmia Case series case sery CDC criteria chest pain clinical Clinical data clinical information Containment COVID-19 defined determined by Diagnosis Dyspnea eight Electrocardiography elevated female females Germany healthy individuals Hospitalization Host Infection Inflammation Information System inoculation magnetic resonance imaging male males Mild Moderna MRI mRNA mRNA vaccination mRNA vaccine mrna-1237 mRNA-1273 myocarditis occur onset of symptoms organ damage pandemic pathophysiology Patient patients Pericarditis Registered reported required retrieved risk factor Risk factors SARS-CoV-2 second dose severe cases severity Side effect Support Symptom symptom onset the disease the vaccine troponin troponin levels vaccination Vaccine variants viral mutation was performed [DOI] 10.1186/s40001-022-00695-y PMC 바로가기 [Article Type] Case Reports
Factors associated with the intention to participate in COVID-19 vaccine clinical trials: A cross-sectional study in PeruResearch article Published on 2022-06-012022-10-05 Journal: Vaccine [Category] 임상, [키워드] Analysis analyzed Associated factors clinical trial clinical trials coronavirus COVID-19 COVID-19 vaccine cross-sectional cross-sectional study database Effectiveness evaluate Factor Factors generate Healthcare professional individual information Intention Intention to participate involved male objective outcome Poisson regression model Result Side effect the vaccine Trial Vaccine was used [DOI] 10.1016/j.vaccine.2022.04.003 [Article Type] Research article
Acceptance and willingness to pay under the different COVID-19 vaccines: A contingent valuation methodResearch article Published on 2022-06-012022-10-05 Journal: Research in social & administrative pharmacy : RSA [Category] 변종, [키워드] acceptance addition Affect affecting approach Characteristics collected conducted Contingent valuation method COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine cross-sectional survey develop Effectiveness expressed Factor Government highest hypothetical identify IMPROVE knowledge Linear regression Logistic regression Multiple multivariate objective Perceived risk predictor question Result safety profile the vaccine understanding vaccination Vaccine Vaccines was performed was used Willingness to pay [DOI] 10.1016/j.sapharm.2022.06.001 [Article Type] Research article
Effect of Text Messaging and Behavioral Interventions on COVID-19 Vaccination Uptake: A Randomized Clinical TrialRandomized Controlled Trial Published on 2022-06-012022-10-05 Journal: JAMA Network Open [Category] 임상, [키워드] absolute difference age assigned black Cell clinical clinician conducted COVID-19 COVID-19 vaccine detectable Effect evaluate factorial design first dose group Health health system Hispanic increase in initial intent-to-treat intention-to-treat basis Latino outcome Patient Philadelphia Population primary care Primary outcome proportion randomized clinical trial Randomly receive receiving respond responses secondary text the mean the vaccine Trial trial protocol vaccination vaccine dose white [DOI] 10.1001/jamanetworkopen.2022.16649 PMC 바로가기 [Article Type] Randomized Controlled Trial