translational – Page 21 – Communicable Diseases Research

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

Research paper

Published on 2020-04-022022-11-01
Journal: EBioMedicine [Category] COVID-19, MERS, SARS,

Translating COVID-19 Pandemic Surge Theory to Practice in the Emergency Department: How to Expand Structure

Concepts in Disaster Medicine

Published on 2020-03-272022-10-31
Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, MERS,

[키워드] agency approach COVID-19 COVID-19 pandemic determine Emergency expand Government health-care system Multiple pandemic Pandemics Practice promote SARS-CoV-2 Structure surge capacity theory translational translational science
[DOI] 10.1017/dmp.2020.57 PMC 바로가기 [Article Type] Concepts in Disaster Medicine

Comparative Analysis of Gene Expression in Virulent and Attenuated Strains of Infectious Bronchitis Virus at Subcodon Resolution

Genome Replication and Regulation of Viral Gene Expression

Published on 2019-06-262022-10-30
Journal: Journal of Virology [Category] Coronavirus, MERS,

[키워드] Analysis avian coronavirus Cell cellular changes in chick coding region Comparative complex conserved Coronaviruses data set Differential gene expression differentially expressed downstream Efficiency expand facilitated form Frame Gene Expression gene network generate Genome genomic RNA High-resolution host cell response host genes IBV IBV infection Improved include indicated Infection Infectious Bronchitis Virus isolates kidney Like Molecular biology mRNA transcript nucleocapsid occur ORF ORF4b pathogen pathogenic positive-sense quantification Replication Resolution ribosome profiling RNA genome RNA virus RNAseq Sequencing sgmRNA sgmRNA transcripts sgmRNAs Single nucleotide polymorphism single-stranded Spread strain Strains subgenomic mRNA Transcription translation translational Triplet upregulation Vaccination strategy vaccine candidate Variation viral RNA synthesis virus virus infection
[DOI] 10.1128/JVI.00714-19 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression

Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response

인간 나병 병변의 이중 RNA-시퀀싱은 숙주 면역 반응과 관련된 세균 결정 인자를 식별합니다.

Article

Published on 2019-03-262024-08-24
Journal: Cell Reports [Category] 한센병,

[키워드] bioinformatics Computational biology Heat shock host-pathogen humoral immunology Microbiology mycobacteria Plasma cell Sequencing systems immunology Transcriptome translational Tuberculosis

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation

포유류 Hbs1L 결핍은 Pelota 고갈 및 80S 모노솜 축적과 관련된 선천적 기형 및 발달 지연을 유발합니다

Research Article

Published on 2019-02-012022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 4EBP1 accompanied accumulation addition affecting aggregation Anomaly baseline biallelic mutation biallelic mutations binding cause caused Cell cells Characteristics characterized coding region conditions control mechanisms controls Critical deficiency demonstrated Depletion developmental delay downstream Effect Efficiency element expression facial fibroblast fibroblasts functional growth Hbs1L human cell human cells humans hypotonia implicated increase in inhibition involved knockdown lack lead Loss mechanism mice monosome mouse model mRNA mRNA level mTOR mTOR expression murine Mutation ortholog pathway Patient pelo phenotype phenotypic Phosphorylation polysome proteasomal proteasome Protein protein expression Quality control reduced Regulation reported rescued restored resulting ribosomal RNA ribosome ribosomes RNA RT-PCR Sequencing Support the patient These data tissues transcript translation translational upregulation utilization western blot Western blot analyses Western blot analysis yeast
[DOI] 10.1371/journal.pgen.1007917 PMC 바로가기 [Article Type] Research Article

Overexpression of the nucleocapsid protein of Middle East respiratory syndrome coronavirus up-regulates CXCL10

Research Articles

Published on 2018-09-212022-10-28
Journal: Bioscience Reports [Category] Coronavirus,

[키워드] A549 cells addition airway epithelial cell antiviral genes antiviral response cause cells cellular processe CXCL10 dendritic cells determine Factor fibroblast cells Genes high mortality rate Host Human IL6 IL8 independent infected cell Infection interactions knowledge lung MERS-CoV Middle East Middle East respiratory syndrome Coronavirus monoclonal antibody monocyte-derived macrophage motif murine N-terminal domain nucleocapsid nucleocapsid protein overexpressed overexpression Patient PCR Protein regulate regulated reported residue Respiratory disease respiratory syndrome coronavirus secretion selected Severity of disease TNF transcriptional transcriptionally transiently transfected translational up-regulate up-regulated was used
[DOI] 10.1042/BSR20181059 PMC 바로가기 [Article Type] Research Articles

A RATional choice for translational research?

Article

Published on 2016-10-012023-08-30
Journal: Disease Models & Mechanisms [Category] E형 간염,

[키워드] CRISPR Genomics model organism RAT translational
[DOI] 10.1242/dmm.027706 PMC 바로가기

Regulation of Stress Responses and Translational Control by Coronavirus

Review

Published on 2016-07-042022-10-28
Journal: Viruses [Category] Coronavirus,

Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation

Research Article

Published on 2016-03-292022-10-29
Journal: mBio [Category] Coronavirus,

[키워드] accessory protein activate Activation acute respiratory syndrome antiviral activity Betacoronavirus calu-3 cells cell death characterized cleave contribute coronavirus Coronaviruses CoV Critical cytoplasmic dsRNA enzyme expressed expression level genes encoding Genome highly pathogenic homolog Host host antiviral response host innate immunity IFN IFN signaling in vivo model inactivation Infection Innate immunity interferon involved Like Lineage mechanism MERS MERS-CoV MERS-CoV infection Middle East murine mutant NLS NS2 NS4b nuclear localization signal nucleus offer other coronaviruses Pathogenesis pathway potential mechanism Prevent Protein provide Replication reported required respiratory respiratory syndrome coronavirus RNA RNase SARS-CoV single-stranded Spread ssRNA subsequent therapeutic intervention translational type I interferon viral double-stranded RNA viral pathogenesis viral replication virulence
[DOI] 10.1128/mBio.00258-16 PMC 바로가기 [Article Type] Research Article

High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling

Research Article

Published on 2016-02-262022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] applicability approach Betacoronavirus carried Cell coronavirus Coronaviruses Course culture cell deep sequencing determine digestion Efficiency epidemic diarrhea family Coronaviridae feature Frame frameshift Gene Expression Genome genomic high mortality rate Host host-virus interactions identify Infection investigated knowledge living cell mapped member MERS-CoV MHV MHV-A59 Middle East MONITOR mouse hepatitis virus mRNA mRNAs murine nucleotide Open reading frame open reading frames ORF ORFs Other pandemic Pathogens polyprotein positive pp1a Precision Profiling profiling analysis PROTECT purified regions Regulation Regulatory Replication ribosome RNA RNA sequencing RNA virus RNA viruses SARS-CoV sensitivity tissue transcript Transcription Transcriptome transcripts translated translation translational Triplet upstream viral mRNA Viral RNA virus was performed
[DOI] 10.1371/journal.ppat.1005473 PMC 바로가기 [Article Type] Research Article