Assessment of NKG2C copy number variation in HIV-1 infection susceptibility, and considerations about the potential role of lacking receptors and virus infection Research Published on 2022-03-222022-10-05 Journal: Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] absence activating assessment association Cell cells Clinical features Co-infection coding Cohort Complete controls evaluated expressed expression Frequency function genetic background genotyping HBV HCV healthy blood donors HIV HIV infection HIV-1 HIV-1 infection HIV-infected patient Host Human individuals Infection involved knowledge natural PCR Phenotypes polymorphism protein expression receptor signaling pathway susceptibility triggered Variation virus infection was performed [DOI] 10.1038/s10038-022-01029-w [Article Type] Research
A New Perspective of COVID-19 Infection: An Epigenetics Point of ViewReview Article Published on 2022-03-192022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] ACE2 age cellular changed Coronavirus disease 2019 Coronavirus infection COVID-19 COVID-2019 enzyme Epigenetic epigenetic modification epigenetics Genome highlight homoeostasis Host Infection Interaction Methylation Modification New Point protease provided receptor serine 2 susceptibility transmembrane Variation View viral infection viral replication virus virus infection with COVID-19 Wuhan, China [DOI] 10.1055/s-0041-1736565 PMC 바로가기 [Article Type] Review Article
Cardiorenal Disease in COVID-19 PatientsCOVID-19 환자의 심혈관 질환Review Published on 2022-03-182022-09-11 Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association Atherosclerosis Cardiorenal Disease caused coding Comorbidities Comorbidity Complication component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical diabetes disease Endothelial dysfunction enzyme fusion Genetic heart failure high mortality rate human host hypertension Increased indicate management mechanism metabolic syndrome morbidity Novel coronavirus progression recent receptor renal renal disease Research SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity Spike proteins syndrome the disease the spike protein Variation variations virus with COVID-19 [DOI] 10.1155/2022/4640788 PMC 바로가기 [Article Type] Review
Post-lockdown changes of age-specific susceptibility and its correlation with adherence to social distancing measures폐쇄 후 연령별 감수성 변화 및 사회적 거리두기 준수와의 상관관계Article Published on 2022-03-172022-09-11 Journal: Scientific Reports [Category] SARS, 변종, [키워드] 95% CI age average risk Bayesian build change community transmission Contact correlation defined effective estimate Evidence Factors group groups heterogeneity highest Impact impacted implementation increase Infection lifted lockdown lowest measure Measures mortality data Older outbreak Pathogens preventive measure preventive measures reduced reducing reduction reported SARS-CoV-2 transmission Seroprevalence social distancing Social distancing measure social distancing measures susceptibility susceptibility to infection Transmissibility Transmission dynamics Transmission model USA vaccination rate variants Variation was reduced [DOI] 10.1038/s41598-022-08566-6 PMC 바로가기 [Article Type] Article
The importance of accessory protein variants in the pathogenicity of SARS-CoV-2SARS-CoV-2의 병원성에서 보조 단백질 변이체의 중요성Article Published on 2022-03-152022-09-11 Journal: Archives of biochemistry and biophysics [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] accessory protein accessory proteins acute respiratory syndrome coronavirus Affect caused Complete Consensus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathology Critical Cytokines Fatality rate function highest Host IL-1β immune Inflammasome Inflammatory cytokine Inflammatory cytokines interferons interleukin less lowest mechanisms NLR NLRP3 Oceania ORF10 ORF3a ORF6 ORF7a ORF7b ORF8 pathogenicity Protein receptor reported respiratory SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 accessory protein SARS-CoV-2 accessory proteins SARS-CoV-2 proteome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Signaling South America unique variant Variation was determined [DOI] 10.1016/j.abb.2022.109124 PMC 바로가기 [Article Type] Article
Impact of the COVID-19 Pandemic on Patients Without COVID-19 With Acute Myocardial Infarction and Heart FailureObservational Study Published on 2022-03-152022-10-05 Journal: Journal of the American Heart Association [Category] 임상, [키워드] 95% CI Acuity Acute myocardial infarction age analyzed both groups cardiovascular cardiovascular disease Care catheterization changes in Comorbidities Comorbidity COVID-19 COVID-19 pandemic COVID‐19 excess mortality failure health system heart heart failure hospital Hospitalization hospitalizations Impact In-hospital include left heart catheterization mechanism Mortality Myocardial Myocardial infarction no difference Odds ratio outcome Patient proportion reported Result Sex spillover strain Treatment Variation Volume [DOI] 10.1161/JAHA.121.022625 PMC 바로가기 [Article Type] Observational Study
Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma중증급성호흡기증후군 코로나바이러스 2 균주 변이가 바이러스 중화 역가에 미치는 영향: 회복기 혈장의 치료적 사용Comparative Study Published on 2022-03-152022-09-11 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Antibody titers B.1.1.7 B.1.351 Beta circulating collected convalescent convalescent plasma coronavirus coronavirus 2 correlation demonstrated Effect hemagglutination test Live virus live virus neutralizing antibody assay microneutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers plasma samples potency pseudotype reduced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly strain variant variants Variation wild-type virus [DOI] 10.1093/infdis/jiab563 PMC 바로가기 [Article Type] Comparative Study
Mumps to COVID-19: Vaccinated persons remain vulnerable when community uptake is lowCOVID-19에 대한 유행성 이하선염: 예방 접종을 받은 사람들은 지역 사회 이용이 낮을 때 취약한 상태로 남아 있습니다.Article Published on 2022-03-152022-09-11 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] administration booster dose booster doses Care clinical trial clinical trials Community coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 patient effective Efficacy Europe healthcare worker Healthcare workers high risk Infection less Long-term care management mump mumps pandemic Population product risk Risk management SARS-CoV-2 variant severe disease the United State United States vaccination vaccination rate vaccination rates Vaccine vaccine uptake hesitancy COVID-19 mumps acceptance. Variation [DOI] 10.1016/j.vaccine.2022.02.046 PMC 바로가기 [Article Type] Article
Validating and optimizing the method for molecular detection and quantification of SARS-CoV-2 in wastewater폐수에서 SARS-CoV-2의 분자 검출 및 정량화 방법 검증 및 최적화Article Published on 2022-03-152022-09-11 Journal: The Science of the total environment [Category] MERS, SARS, 진단, 치료기술, [키워드] 229E best changes in Community community infections coronavirus COVID-19 COVID-19 disease cycle threshold disease DNA evaluated fecal FIVE followed by HCoV HCoV-229E hCoV-229E. human coronavirus Infection Isolation less methodology Mild molecular Neutral parameter PCR PMMoV prevalence of COVID-19 provide public health qPCR quantification reported RNA extraction RNA isolation kit RT-qPCR Salmon SARS-CoV-2 SARS-CoV-2 detection sensitivity significantly significantly increased Surveillance threshold Ultrafiltration Variation Viral Viral RNA virus viruses was used wastewater [DOI] 10.1016/j.scitotenv.2021.151434 PMC 바로가기 [Article Type] Article
Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2SARS-CoV-2에 감염된 상피 조직 패치에 대한 항바이러스 타이밍, 효능 및 이질성 효과의 다중 스케일 모델Article Published on 2022-03-142022-09-11 Journal: Viruses [Category] SARS, 치료제, [키워드] Affect agent agent-based model Antiviral antiviral therapies antiviral therapy Cell cell-to-cell variability cellular cellular metabolism cellular uptake dosage dose Effect Efficacy epithelial Epithelial Tissue Frequency homogeneous include Infection likelihood lowest lung tissue metabolism metabolite Model mPBPK multiscale model outcome outcomes parameters patch permeability pharmacokinetic potency predict Remdesivir SARS-CoV-2 significantly Super-spreader tissue tissue model treat Treatment treatment initiation Treatment outcome Variability Variation viral infection viral infections virtual tissue simulation. [DOI] 10.3390/v14030605 PMC 바로가기 [Article Type] Article