Systemic steroids and risk of fecal-oral shedding and increased transmission of SARS-CoV-2 in pemphigus cases천포창 사례에서 전신 스테로이드 및 대변-구강 배출 위험 및 SARS-CoV-2 전파 증가Article Published on 2020-11-012022-09-11 Journal: Clinics in dermatology [Category] SARS, 변종, [키워드] acquisition autoantibodies autoantibody Autoimmune blistering breach desmoglein disease integumentary system involved mucosal mucosal barrier mucous membranes Pathogenesis Pathogens pemphigus risk Shield steroid syndrome systemic therapeutic transmission of SARS-CoV-2 Treatment Usher syndrome variants virion vulgaris [DOI] 10.1016/j.clindermatol.2020.06.006 PMC 바로가기 [Article Type] Article
Physics of virus transmission by speaking droplets530 Published on 2020-10-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, MERS, SARS, [키워드] algebraic calculation COVID-19 COVID-19 pandemic decrease droplet estimate example help initial Physics SARS-CoV-2 speaking droplets Support virion virus transmission [DOI] 10.1073/pnas.2011889117 PMC 바로가기 [Article Type] 530
End-to-End Protocol for the Detection of SARS-CoV-2 from Built EnvironmentsResearch Article Published on 2020-10-062022-10-29 Journal: mSystems [Category] COVID-19, [키워드] acute respiratory syndrome Aerosols approach automated built environments cause collected Combination conducted Contact coronavirus coronavirus disease COVID-19 demonstrated detect virus detection Detection limit determine droplet effective Efficiency end-to-end Environment evaluate fomites high-touch surface highest human infection impacts inactivated include information inhibit LAMP pandemic protocol quantitative PCR required respiratory virus responsible RNA extraction RT-qPCR SARS-CoV-2 Shield shown surface sampling Swab tested through contact transcriptase Transmission transmitted Treatment viral control viral fragment viral particle Viral particles Viral RNA virion virus was determined [DOI] 10.1128/mSystems.00771-20 PMC 바로가기 [Article Type] Research Article
An approach to lifting self-isolation for health care workers with prolonged shedding of SARS-CoV-2 RNASARS-CoV-2 RNA의 장기간 배출이 있는 의료 종사자를 위한 자가 격리 해제 방법Original Paper Published on 2020-10-062022-09-10 Journal: Infection [Category] MERS, SARS, 치료기술, 치료제, [키워드] approach assumed authority Blood blood sample Blood samples carriers Cell culture Clinical improvement collected convalescent COVID-19 Ct-value Ct-values ELISA test European Guidance HCW Health authority Health care worker healthcare worker healthy infectiousness interval Isolation lack median medical records nasopharyngeal negative RT-PCR neutralization test Neutralizing antibodies neutralizing antibody non-infectiousness onset of symptoms Oropharyngeal oropharyngeal swab oropharyngeal swabs Particle PCR tests PCR-confirmed performed positive positive PCR positive PCR result positive RT-PCR Public remained respiratory respiratory specimen respiratory specimens Result RNA RT-PCR RT-PCR Ct RT-PCR tests SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral RNA SARS-CV-2 Self-isolation serum neutralization test serum samples Swab swab sample symptom onset tested the patient threshold Viral virion virus growth virus isolation was performed [DOI] 10.1007/s15010-020-01530-4 PMC 바로가기 [Article Type] Original Paper
Identification of potential inhibitors against SARS-CoV-2 by targeting proteins responsible for envelope formation and virion assembly using docking based virtual screening, and pharmacokinetics approachesArticle Published on 2020-10-012023-07-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, [키워드] envelope molecular docking SARS-CoV-2 Simulation structural proteins virion [DOI] 10.1016/j.meegid.2020.104451 PMC 바로가기
Treatment with Exogenous Trypsin Expands In Vitro Cellular Tropism of the Avian Coronavirus Infectious Bronchitis VirusArticle Published on 2020-09-292022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition animal coronavirus cause Cell Cell culture cells cleavage contagious coronavirus Culture Effect Ex vivo exhibiting Exogenous exogenous trypsin facilitated glycoprotein IBV in vitro Infection Infectious Bronchitis Virus Laboratory organ overcome passages platform protease Protein provide replicate Replication Research Respiratory disease responsible S1 and S2 S2′ cleavage significantly increased Spike protein strain Strains subunit subunits titres Treatment tropism trypsin vaccine production virion were assessed [DOI] 10.3390/v12101102 PMC 바로가기 [Article Type] Article
Minimum Sizes of Respiratory Particles Carrying SARS-CoV-2 and the Possibility of Aerosol GenerationReview Published on 2020-09-232022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] acute respiratory syndrome aerosol Aerosol generation aerosol suspension time aerosol transmission air infection Airborne transmission assumption bioaerosol calculate calculated carrier Carrying caused contagious disease coronavirus COVID-19 COVID-19 patient COVID-19 patients decrease droplet evaluate Generation limitation MERS microorganisms Middle East respiratory syndrome Coronavirus minimum minimum size Nosocomial infection Particle Probability respiratory respiratory fluid respiratory particle SARS SARS-CoV-2 SARS-CoV-2 bioaerosol severe acute respiratory syndrome coronavirus 2 viral infection Viral load virion virus virus transmission viruses [DOI] 10.3390/ijerph17196960 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Virion Stabilization by Zn BindingMolecular Biosciences Published on 2020-09-172022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] activated Antigen binding cellular expressed feasibility host cell Hypothesis Interaction involved lack maturation molecular dynamics computer simulation ORF7a orf7a and orf8 proteins ORF8 Protein Proteins SARS-CoV-2 Tetherin/BST2 virion Zinc zinc finger Zn binding [DOI] 10.3389/fmolb.2020.00222 PMC 바로가기 [Article Type] Molecular Biosciences
Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humansArticle Published on 2020-09-162022-10-29 Journal: Nature Communications [Category] Coronavirus, [키워드] acting Analysis arising Betacoronavirus binding change circulation cryo-EM cryo-EM structure Cryoelectron microscopy domain enzyme Evolution feature glycosylated Haemagglutinin HKU1 host adaptation Human incompatible membrane fusion OC43 Particle promote Proteins Receptor binding receptors reveal sialic acid Structure utility viral evolution virion Virus structures zoonotic [DOI] 10.1038/s41467-020-18440-6 PMC 바로가기 [Article Type] Article
The Challenges of Vaccine Development against Betacoronaviruses: Antibody Dependent Enhancement and Sendai Virus as a Possible Vaccine VectorReviews Published on 2020-09-042022-10-30 Journal: Molecular Biology [Category] COVID-19, [키워드] ADE Administered Amino acid Antibody-dependent enhancement antigenic Antiviral approach betacoronaviruses caused Cell-mediated immune responses challenge Combination conformational changes conservative antigenic determinants coronavirus COVID-19 Dependent determinant development effective elicit enhancement expressing glycosylation help humoral Immunity inactivated induce Infection intranasally MERS-CoV mucosal mucosal immune murine respirovirus new SARS-CoV-2 provide respiratory pathogen respiratory tract risk S-protein Safe SARS-CoV-1 SARS-CoV-2 Sendai virus stimulate targeting the spike protein the vaccine Trial Vaccine vaccine vector vector viral infection Viral protein viral vectors virion [DOI] 10.1134/S0026893320060151 PMC 바로가기 [Article Type] Reviews