Spectrum of neuroimaging findings in COVID-19Pictorial Review Published on 2021-01-012022-10-27 Journal: The British Journal of Radiology [Category] COVID-19, MERS, [키워드] change China Complication COVID-19 Critical Critically ill Encephalopathy feature Hemorrhagic hospitalized COVID-19 hospitalized patient hypertensive hypoxic include infections manifestation multiple sclerosis outbreak positive patient Spectrum spread to state stroke syndrome Venous thrombosis Virus Disease worldwide pandemic [DOI] 10.1259/bjr.20200812 PMC 바로가기 [Article Type] Pictorial Review
Mismatch between circulating cytokines and spontaneous cytokine production by leukocytes in hyperinflammatory COVID-19과염증 COVID-19에서 백혈구에 의한 순환 사이토카인과 자발적 사이토카인 생산 간의 불일치Clinical Trial Published on 2021-01-012022-09-12 Journal: Journal of leukocyte biology [Category] MERS, 임상, 진단, [키워드] activated Activation analyzed blockade cellular circulating cytokine circulating leukocyte contribute Control controls COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production Cytokine storm cytokine storm, monocytes. Cytokines disease example flow cytometry healthy control healthy controls hyperinflammation Hyperinflammatory IL-1β IL-6 IL-8 immunoassay investigated leukocyte LPS lymphocyte mismatch monocyte Monocytes Patient patients with COVID-19 PBMC produced recruited Sepsis sepsis patient sepsis patients severe COVID-19 Support surface marker TNF Treatment university was used were measured worldwide pandemic [DOI] 10.1002/JLB.5COVBCR0720-310RR PMC 바로가기 [Article Type] Clinical Trial
Spectrum of neuroimaging findings in COVID-19COVID-19의 신경 영상 소견 스펙트럼Pictorial Review Published on 2021-01-012022-09-12 Journal: The British Journal of Radiology [Category] 진단, [키워드] Acute disseminated encephalomyelitis change China Complication COVID-19 Critical Critical illness Critically ill Disseminated encephalomyelitis Encephalopathy feature flare Hemorrhagic hospitalized COVID-19 hospitalized patient hospitalized patients hypertensive hypoxic include infections manifestation meningoencephalitis multiple sclerosis Neurological complications outbreak positive patient Spectrum spread to state stroke syndrome thrombosis Venous thrombosis Viral Virus Disease worldwide pandemic [DOI] 10.1259/bjr.20200812 PMC 바로가기 [Article Type] Pictorial Review
Mutational spectra of SARS-CoV-2 isolated from animalsMicrobiology Published on 2020-12-182022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome alignment Amino acid amino acid substitution amino acid substitutions Analysis animals clade Coronavirus-2 determine dog Evolution Evolution of SARS-CoV-2 exhibited F486L Frame furin cleavage site genome sequence heptad repeat humans infect isolate mink Molecular epidemiology N-terminal domain not differ nucleocapsid ORF1ab ORF3a ORF6 pathogenic Phylogenetic analysis Protein Proteins Q498H RBM receptor-binding motif S protein SARS-CoV-2 SARS-CoV-2 isolate sequence sequence identity Sequencing Seven the S protein unique worldwide pandemic Y453F [DOI] 10.7717/peerj.10609 PMC 바로가기 [Article Type] Microbiology
Identification and Validation of a Novel Clinical Signature to Predict the Prognosis in Confirmed Coronavirus Disease 2019 PatientsRandomized Controlled Trial Published on 2020-12-152022-10-05 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, [키워드] Accuracy age Analysis both group C-reactive protein caused characteristic clinical Confirmed coronavirus coronavirus disease COVID-19 COVID-19 patient Critically ill demonstrated disease group groups highest identification identify indicated log-rank test Lymphocyte count mortality rate multivariate Cox regression neutrophil count novel Patient performed predict prediction Predictive Probability procalcitonin Prognosis prognostic biomarker randomly divided reduce risk risk model ROC ROC analysis signature significantly stratified surpassed survival the disease Treatment validation was selected worldwide pandemic [DOI] 10.1093/cid/ciaa793 PMC 바로가기 [Article Type] Randomized Controlled Trial
High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study고용량 콜레칼시페롤 부스터 요법은 COVID-19 환자의 사망률 감소와 관련이 있습니다: 횡단면 다중 센터 관찰 연구Clinical Trial Published on 2020-12-112022-08-13 Journal: Nutrients [Category] MERS, SARS, 임상, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease 25-hydroxyvitamin D 95% CI affected appear baseline carried cholecalciferol cholecalciferol booster therapy cholecalciferol therapy clinical trial Cohort collected confounder coronavirus disease COVID-19 COVID-19 mortality determine disease Efficacy hospitalised in-patient Logistic regression Mortality Novel coronavirus novel coronavirus 2019 novel coronavirus disease observational study participant Patient patients pharmacological management population studies predictor predictors public health recruited reduced risk replicated SARS-CoV-2 serum serum 25-hydroxyvitamin D therapeutic option therapeutic options Treatment UK hospitals validation cohort Vitamin D Vitamin D status vitamin D treatment was used with COVID-19 worldwide pandemic [DOI] 10.3390/nu12123799 PMC 바로가기 [Article Type] Clinical Trial
Safety and Efficacy of the BNT162b2 mRNA Covid-19 VaccineClinical Trial Published on 2020-12-102022-10-04 Journal: The New England Journal of Medicine [Category] MERS, SARS, 임상, [키워드] 1:1 acute respiratory syndrome age assigned baseline BNT162b2 BNT162b2 mRNA BNT162b2 vaccine body-mass characterized conditions coronavirus coronavirus disease defined dose doses effective effective vaccine Efficacy ENCODE fatigue first dose full-length spike protein groups headache incidence Infection injection laboratory-confirmed median Mild-to-moderate nucleoside-modified RNA observer-blinded occurred of BNT162b2 Older Pain participant Placebo placebo recipient placebo-controlled prefusion primary end point randomization Randomly receive Result resulting Safety safety profile SARS-CoV-2 second dose Serious Adverse Event Sex subgroup the vaccine Trial two-dose regimen Vaccine Vaccines worldwide pandemic [DOI] 10.1056/NEJMoa2034577 PMC 바로가기 [Article Type] Clinical Trial
Severe Acute Respiratory Syndrome Coronavirus 2-Induced Neurological ComplicationsCell and Developmental Biology Published on 2020-12-102022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome antiviral drug clinician Complication coronavirus COVID-19 COVID-19 patients dry cough Guillain–Barrè syndrome highlight immune immunomodulatory therapy IMPROVE induce Infection Inflammation Inflammatory response management manifestation mechanisms MONITOR multiple sclerosis nervous system Neurological complication Neurological complications neurological sign predominant respiratory respiratory symptom SARS-CoV-2 SARS-COV-2 infection Specific stroke Supportive treatment Treatment virus worldwide pandemic [DOI] 10.3389/fcell.2020.605972 PMC 바로가기 [Article Type] Cell and Developmental Biology
Telemedicine in Heart Failure During COVID-19: A Step Into the FutureCardiovascular Medicine Published on 2020-12-092022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Admission benefit Care caused change coronavirus Coronavirus disease 2019 COVID-19 decompensated heart failure detect discharge failure Follow-up Follow-up visit forward triage Future heart heart failure Hospitalization hospitals limitation lockdown Mortality pandemic paradoxical Patient patient mortality Patients at Home Prevent progression provide quarantine reduction remote monitoring step Symptom Telemedicine telerehabilitation the patient Treatment undergo virtual visits worldwide pandemic [DOI] 10.3389/fcvm.2020.612818 PMC 바로가기 [Article Type] Cardiovascular Medicine
Early prediction and identification for severe patients during the pandemic of COVID-19: A severe COVID-19 risk model constructed by multivariate logistic regression analysisResearch Theme 1: COVID-19 Pandemic Published on 2020-12-042022-10-31 Journal: Journal of Global Health [Category] COVID-19, MERS, SARS, [키워드] age albumin Analysis caused Clinical characteristics Clinical data clinician Comorbidities Corona COVID-19 demonstrated duration of fever early stage elevated enrolled evaluate Factor force help hypertension identify illness onset independent Infectious disease Lymphocyte count lymphopenia mechanical ventilation Mild Mortality Most patient multivariate logistic regression Negative predictive value neutrophil lymphocyte ratio NLR oxygen pandemic Patient patients with COVID-19 Positive predictive value Predictive predictor proportion receiver operating characteristic reducing required respiratory symptoms Result retrospective risk ROC ROC Curve second Sensitivity and specificity severe COVID-19 severe group Severe patient severe patients therapeutic Treatment two groups university viral clearance was used were used worldwide pandemic [DOI] 10.7189/jogh.10.020510 PMC 바로가기 [Article Type] Research Theme 1: COVID-19 Pandemic