A quadruple blinded placebo controlled randomised trial to evaluate the effectiveness of an Iodine complex for patients with mild to moderate COVID-19 in Pakistan (I-COVID-PK): A structured summary of a study protocol for a randomised controlled trial파키스탄에서 경증에서 중등도의 COVID-19 환자에 대한 요오드 복합체의 효과를 평가하기 위한 4중 맹검 위약 대조 무작위 시험(I-COVID-PK): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-02-102022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 30-Day mortality Admission age alleviation alleviation of symptom approved Arm ARMS baseline blinded Blinding calculated Care care providers Chest chest scan Chronic illness clinic clinical Clinical improvement Clinical management co-morbidities co-morbidity comparator complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 adult patient COVID-19 adult patients Disinfection dissemination doctor Effectiveness Efficacy element enrolled evaluate excluded four group four groups Gender groups HRCT Infection information initial initial symptom initial symptoms Intention investigator investigators Iodine IRB lung involvement management guidelines Mild mild to moderate mild to moderate disease Moderate COVID-19 moderate disease morbidities National Health Service National Health Services non-pregnant females number objective outcome Pakistan participant Participants Patient patients PCR Placebo placebo-controlled Polymer positive Primary outcomes protocol radiological radiological improvement randomised randomised controlled trial Randomised trial randomization Randomized receiving recruited recruitment Registered remained reported resolved RT-PCR Sample size SARS-CoV-2 RT-PCR secondary outcome severity severity of symptom shown Standard standard care status Study protocol supplementary material Symptom symptomatic syrup the patient time Trial Version Viral viral clearance website [DOI] 10.1186/s13063-021-05081-3 PMC 바로가기 [Article Type] Letter
Direct antivirals working against the novel coronavirus: azithromycin (DAWn-AZITHRO), a randomized, multicenter, open-label, adaptive, proof-of-concept clinical trial of new antivirals working against SARS-CoV-2—azithromycin trial신종 코로나바이러스에 대항하는 직접 항바이러스제: 아지스로마이신(DAWn-AZITHRO), 무작위, 다기관, 공개 라벨, 적응형, SARS-CoV-2에 대해 작용하는 새로운 항바이러스제의 개념 증명 임상 시험 - 아지스로마이신 시험Study Protocol Published on 2021-02-092022-09-10 Journal: Trials [Category] MERS, 임상, 치료제, [키워드] 7-category ordinal scale adaptive Admission amplify antibiotic Antiviral Antiviral effect Azithromycin Belgium blunt Bronchoalveolar lavage Care chance chest CT scan clinical Clinical improvement clinical trial coronavirus SARS-CoV-2 Course COVID COVID-19 COVID-19 disease cytokine cytokine signaling decrease defined diagnosed with COVID-19 Diagnosis Direct discharge disease disease course drug Efficacy eligible EudraCT feature health regulations Hospitalized hospitalized patient hospitalized patients Hydroxychloroquine hyperinflammatory state immunomodulatory properties implicated in vitro include Inclusion Intervention life Local Macrolide medical need multicenter name Nasopharyngeal swab National Novel coronavirus novel coronavirus SARS-CoV-2 Open-label Ordinal Scale pathway Pathways Patient patients patients with COVID-19 PCR Phase 2 Primary outcome proof-of-concept clinical trial radiological Randomized Randomized controlled trial receive recruit SARS-CoV-2 severe COVID-19 disease shown Standard Standard of care study inclusion supplementary material Support sustained symptomatic the disease the WHO treatment effect treatment effects treatment group treatment strategy Trial Viral viral replication widespread with COVID-19 [DOI] 10.1186/s13063-021-05033-x PMC 바로가기 [Article Type] Study Protocol
Description of a Multi-faceted COVID-19 Pandemic Physician Workforce Plan at a Multi-site Academic Health SystemOriginal Research Published on 2021-02-092022-10-31 Journal: Journal of General Internal Medicine [Category] COVID-19, MERS, SARS, [키워드] Calgary Care component components COVID-19 COVID-19 pandemic Critical Delivery of healthcare Department description develop disease outbreaks Health health system health systems health workforce healthcare hospital hospitals implementation initial Inpatient manuscript Medicine operation outcomes pandemic Patient Personal protective equipment physician Physicians plan public health reached Result Seven supplementary material Support System unique with COVID-19 [DOI] 10.1007/s11606-020-06543-1 PMC 바로가기 [Article Type] Original Research
CoronaHiT: high-throughput sequencing of SARS-CoV-2 genomesCoronaHiT: SARS-CoV-2 게놈의 높은 처리량 시퀀싱Method Published on 2021-02-092022-08-13 Journal: Genome Medicine [Category] MERS, 유전자 메커니즘, [키워드] ARTIC Clustering demonstrated flexible Genetic Genome genome coverage Illumina Illumina platforms likelihood MinION Multiplexing Nanopore NGS pandemic PCR products platform protocol rapid expansion SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequencing SARS-CoV-2 genomes sequenced Sequencing supplementary material transposase was obtained [DOI] 10.1186/s13073-021-00839-5 PMC 바로가기 [Article Type] Method
Prevalence of interstitial pneumonia suggestive of COVID-19 at 18 F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study팬데믹 기간 동안 유병률이 높은 국가의 종양학적 무증상 환자에서 18 F-FDG PET/CT에서 COVID-19를 암시하는 간질성 폐렴의 유병률: 국가 다중심적 후향적 연구Observational Study Published on 2021-02-092022-09-10 Journal: European Journal of Nuclear Medicine and Molecular [Category] MERS, SARS, 임상, 치료기술, [키워드] 18F-FDG PET/CT alteration Asymptomatic asymptomatic patient average country COVID COVID-19 COVID-19 case COVID-19 pandemic CT finding demonstrated Diagnosis diffusion fluorine help Incidental findings incidentally detected interstitial interstitial pneumonia Italian centers Italy lung majority management National no significant difference observational study pandemic Patient pattern pet PET/CT Pneumonia positron emission Positron emission tomography Prevalence recognize Result retrospective Retrospective study SARS-CoV-2 significant difference significant increase significantly higher subsequent supplementary material tomography virus was done was performed [DOI] 10.1007/s00259-021-05219-0 PMC 바로가기 [Article Type] Observational Study
Egyptian protocol for living donor liver transplantation (LDLT) during SARS-CoV-2 pandemicMeeting Report Published on 2021-02-092022-10-31 Journal: Egyptian Liver Journal [Category] COVID-19, [키워드] Abstract candidate Care center Committee country Donor Egyptian national protocol highlight hospital LDLT list liver Liver transplantation management National national guideline Patient protocol recipients SARS-CoV-2 SARS-CoV-2 pandemic supplementary material the patient Transplant transplantation Waiting list project [DOI] 10.1186/s43066-020-00074-4 PMC 바로가기 [Article Type] Meeting Report
Impacts of the Covid-19 lockdown and relevant vulnerabilities on capability well-being, mental health and social support: an Austrian survey studyResearch Published on 2021-02-082022-10-28 Journal: BMC Public Health [Category] COVID-19, MERS, [키워드] 95%CI adjusted age Anxiety association Austria average Capabilities Cohort concerning COVID-19 cross-sectional Depression Direct Future HADS health condition Impact IMPROVE instrument Linear regression lockdown Mental mental health multivariable outcome measure OxCAP-MH pandemic participant physical provided public health public health measure reduction reported Resilience response Result significantly higher supplementary material Support Treatment vulnerability Well-being were used [DOI] 10.1186/s12889-021-10351-5 PMC 바로가기 [Article Type] Research
Effects of COVID-19 on in-hospital cardiac arrest: incidence, causes, and outcome – a retrospective cohort studyOriginal Research Published on 2021-02-082022-10-29 Journal: Scandinavian Journal of Trauma, Resuscitation and [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Admission Cardiac arrest Cardiopulmonary resuscitation caused causes Characteristics Clinical parameters comparable Corona Virus Disease Coronavirus disease 2019 Coronavirus-2 COVID-19 declined Defibrillation demographic Effect Frequency Germany global pandemic high mortality rate Horowitz Hospital admission Hospital admissions Hospitalization ICU In-hospital in-hospital cardiac arrest incidence intensive care unit mechanical ventilation multiple organ failure neurological Occurrence organ outcome pandemic Patient patients with COVID-19 recorded Respiratory failure Result Resuscitation Retrospective analysis retrospective cohort study SARS-CoV-2 severity significantly lower study period supplementary material therapy university virus were assessed [DOI] 10.1186/s13049-021-00846-w PMC 바로가기 [Article Type] Original Research
Differences of blood cells, lymphocyte subsets and cytokines in COVID-19 patients with different clinical stages: a network meta-analysis임상 단계가 다른 COVID-19 환자의 혈액 세포, 림프구 하위 집합 및 사이토카인의 차이점: 네트워크 메타 분석Meta-Analysis Published on 2021-02-082022-08-31 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, meta-analysis, [키워드] 95% CI Analysis Blood blood cell Blood cells CD19 CD3 CD4 CD8 Cell Clinical stages conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical critical patients cytokine Cytokines database determine difference elevated Guidance IL-10 IL-1β IL-6 immune Immune suppression Inflammatory inflammatory parameter Injury lymphocyte Lymphocyte subset Lymphocyte subsets mean difference Meta-analysis mild patients network Network meta-analysis neutrophil Patient patients performed Platelet progression Result searched severe and critical patients severity significantly significantly lower Spread Stata supplementary material susceptible cell the disease the mean Treatment WBC were used white White blood cell worsening [DOI] 10.1186/s12879-021-05847-9 PMC 바로가기 [Article Type] Meta-Analysis
Rapid community point-of-care testing for COVID-19 (RAPTOR-C19): protocol for a platform diagnostic studyProtocol Published on 2021-02-082022-10-31 Journal: Diagnostic and Prognostic Research [Category] COVID-19, [키워드] 95% confidence interval Accuracy antibody test results Antibody testing asked baseline blood sample calculated Care chain children clinical care Community community testing contributing to COVID-19 death demographics diagnostic diagnostic tests Effects Electronic health record eligible estimates evaluated feasible Health hospitalisation household contacts household transmission Impact individual Infection ISRCTN Laboratory Negative predictive value outcome outcomes participant Patient patient reported performed PHE platform POCT point-of-care point-of-care test point-of-care tests positive Prevalence primary care protocol public health Public Health England Rapid reaction recruited reducing reference standard RT-PCR SARS-CoV-2 antibody testing SARS-CoV2 SARS-CoV2 infection specificity supplementary material Surveillance Swab symptomatic infection Symptoms Testing transcriptase Transmission dynamics [DOI] 10.1186/s41512-021-00093-8 PMC 바로가기 [Article Type] Protocol