SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional ConvergenceReview Published on 2020-08-202022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Accessory accessory protein affecting appear asymptomatic stage Biomedical research Characteristics clinical trial convergence coronavirus COVID-19 COVID-19 pandemic deaths Disease spectrum Divergence evaluated Factor feature Features functional Genome genomic Health homolog Human identity imperative infected case infecting long-lasting magnitude nucleotide ORF8 ORF8ab predict Protein Proteins SARS-CoV SARS-CoV-2 Seven Spread target therapeutic approaches Vaccine while [DOI] 10.3390/pathogens9090677 PMC 바로가기 [Article Type] Review
Animal and translational models of SARS-CoV-2 infection and COVID-19 Reviews Published on 2020-08-202022-10-05 Journal: Mucosal Immunology [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] animal animal model Cell chronic disease Chronic diseases clinical trial Community competing COVID-19 Critical defined described develop disease disease manifestation drugs effective feature global pandemic Head-to-head comparison Human lack patient cohort primary human cell Primary infection SARS-COV-2 infection tissue tissues to define translational [DOI] 10.1038/s41385-020-00340-z [Article Type] Reviews
COVID-19 and readjusting clinical trialsNews Published on 2020-08-202022-10-05 Journal: Lancet (London, England) [Category] 임상, [키워드] clinical trial COVID-19 [DOI] 10.1016/S0140-6736(20)31787-6 [Article Type] News
The Anatomy of the SARS-CoV-2 Biomedical Literature: Introducing the CovidX Network Algorithm for Drug Repurposing RecommendationOriginal Paper Published on 2020-08-202022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, [키워드] Algorithm analyzed Antiviral antiviral drug applied approach benefit biomedical calculated candidate Chloroquine clinical trial clinical trials compounds coronavirus disease COVID-19 COVID-19 pandemic COVID-19 treatment disease drug drug candidate Drug repurposing Evidence Favipiravir Health Hydroxychloroquine identify informatics instance investigated knowledge losartan mechanism Methylprednisolone network network algorithm objective off-label outcome pandemic potential treatments Protein ranking Rapamycin Remdesivir repurposing Result Ritonavir the SARS-CoV-2 Treatment [DOI] 10.2196/21169 PMC 바로가기 [Article Type] Original Paper
Impact of comprehensive molecular testing to reduce antibiotic use in community-acquired pneumonia (RADICAP): a randomised, controlled, phase IV clinical trial protocol지역사회획득 폐렴(RADICAP)에서 항생제 사용을 줄이기 위한 포괄적인 분자 테스트의 영향: 무작위, 통제된, IV상 임상 시험 프로토콜Article Published on 2020-08-202022-09-11 Journal: BMJ Open [Category] MERS, 임상, 진단, [키워드] 1:1 48 hour 48 hours Admission adverse events antibiotic Antibiotic therapy Antibiotic treatment antibiotic use Antibiotics antimicrobial resistance assigned both group both groups causative agent clinical trial ClinicalTrials community-acquired pneumonia De-escalation death Device Diagnosis diagnostic Diagnostic microbiology effective eligible Endpoint Escalation Ethical approval Ethics ethics committee Health health problem hospital hospitalised Hypothesis Immunosuppressed Impact include intensive care intensive care unit admission International intravenous mechanical ventilation Medical devices Medicine molecular molecular diagnostics null hypothesis Open-label parallel group Patient patients Pneumonia primary endpoint Probability protocol randomisation randomised Randomly readmission receive reduce reducing registration number respiratory respiratory infections Result resulting secondary Secondary endpoints Side effects Spanish stability subject [DOI] 10.1136/bmjopen-2020-038957 PMC 바로가기 [Article Type] Article
The 2020 Pandemic: Current SARS-CoV-2 Vaccine DevelopmentImmunology Published on 2020-08-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] antibody dependent enhancement (ADE) approved cause caused China clinical trial coronavirus 2 coronavirus disease Coronavirus disease 2019 (COVID-19) current death deaths described development effective therapy flu-like symptom Genome human coronavirus humans infect infecting Infection International MERS Middle East multi-organ failure outbreak pandemic PHEIC Pneumonia positive-sense single-stranded RNA Prevent public health emergency receptor binding domain (RBD) respiratory respiratory tract SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein Spread Vaccine virus WHO World Health Organization Wuhan [DOI] 10.3389/fimmu.2020.01880 PMC 바로가기 [Article Type] Immunology
Vitamin and mineral supplementation for β-thalassemia during COVID-19 pandemicSystematic Review Published on 2020-08-182022-10-31 Journal: Future Science OA [Category] COVID-19, [키워드] Abstract Alter ascorbic acid benefit boost cholecalciferol clinical trial conducted contributing to COVID-19 COVID-19 pandemic FIVE functions good health and well being identify immune system Immunity maintain material Micronutrient mineral nutrition outbreak oxidative stress Pathogenesis Patient Prevent reducing SARS-CoV-2 Selenium the disease therapy tocopherol Transmission Vaccine Vitamin Zinc β-thalassemia [DOI] 10.2144/fsoa-2020-0110 PMC 바로가기 [Article Type] Systematic Review
A multi-centre open-label two-arm randomised superiority clinical trial of azithromycin versus usual care in ambulatory COVID-19: study protocol for the ATOMIC2 trial보행식 COVID-19에서 아지트로마이신 대 일반 치료의 다기관 공개 라벨 2군 무작위 우월성 임상 시험: ATOMIC2 시험을 위한 연구 프로토콜Study Protocol Published on 2020-08-172022-08-13 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 Adults age all-cause mortality Ambulatory care Analysis anti-bacterial Anti-inflammatory anti-inflammatory properties antibiotic antiviral properties antiviral property Azithromycin Bacterial infection Biomarkers Blood Care Clinical diagnosis clinical trial clinical utility clinically Coronavirus disease 2019 Coronavirus infections Course COVID-19 COVID-19 infection COVID-19 symptoms cytokine Cytokines death determine diagnosed disease early disease EudraCT Follow-up G-CSF GM-CSF hospital include initial Interleukins invasive Macrolide management mechanical ventilation MERS-CoV moderate moderate to severe Mortality multi nasal Non-invasive non-invasive mechanical ventilation ongoing trial Open-label Opened Other pandemic coronavirus participant pathway Patient PCR-confirmed PCR-confirmed diagnosis presenting pro-inflammatory cytokine pro-inflammatory cytokines progression proportion randomisation randomised reduce Respiratory failure risk Safe SAR-CoV-2 SARS-CoV secondary bacterial infection Secondary objective Secondary objectives severe disease severe pneumonia severe SARS severity severity of illness standard care Study protocol suppression Symptom Symptoms Therapeutic benefit therapy treat Trial Trial registration Two-arm usual care with COVID-19 [DOI] 10.1186/s13063-020-04593-8 PMC 바로가기 [Article Type] Study Protocol
COVID-19, Companion Animals, Comparative Medicine, and One HealthVeterinary Science Published on 2020-08-142022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] accelerate animals Antiviral antiviral drug approach caused clinical development clinical trial companion animal Comparative comparative medicine coronavirus Coronaviruses COVID-19 COVID-19 pandemic drug effort ENhance enhanced faster GS-5734 Health Health Science highlight human clinical trial immune Immune-mediated knowledge Medicine modulating one health pandemic Pandemics Public RDV recognizing Remdesivir (RDV, GS-5734) Research researcher SARS-CoV-2 SARS-CoV2 significantly stimulated tested Treatment Trial Vaccine Vaccines Vasculitis viral pathogens while zoo animal Zoonotic coronavirus [DOI] 10.3389/fvets.2020.00522 PMC 바로가기 [Article Type] Veterinary Science
Efficacy of a Chinese herbal formula on hepatitis B e antigen-positive chronic hepatitis B patientsClinical Trial Published on 2020-08-142023-06-12 Journal: World journal of gastroenterology [Category] B형 간염, [키워드] Chinese Herbal Formula treatment Chronic Hepatitis B clinical trial hepatitis B e antigen clearance Hepatitis B e antigen seroconversion Hepatitis B virus DNA reduction. [DOI] 10.3748/wjg.v26.i30.4501 PMC 바로가기 [Article Type] Clinical Trial