A new identified suppressor of Cdc7p/SepH kinase, PomA, regulates fungal asexual reproduction via affecting phosphorylation of MAPK-HogACdc7p/SepH 키나아제의 새로 확인된 억제제인 PomA는 MAPK-HogA의 인산화에 영향을 주어 진균 무성 생식을 조절합니다Research Article Published on 2019-06-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Affect affecting asexual asexual reproduction Author bypass bypassing cascade Cell composed conidiation conserved Crosstalk cytokinesis environmental factors environmental niche event finding fungal fungi glycerol indicated kinases MAPK mitogen mitogen-activated protein kinase mutant nidulan nidulans osmotic overexpression pathway Pathways phosphorylated Phosphorylation Protein protein kinase protein phosphorylation regulate regulated required respond septation Signaling Stress suppresse suppressor tyrosine upstream [DOI] 10.1371/journal.pgen.1008206 PMC 바로가기 [Article Type] Research Article
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus PathogenesisResearch Article Published on 2018-10-092022-10-29 Journal: mBio [Category] Coronavirus, [키워드] absence Activation acute respiratory syndrome Adaptive immune response animal models ARDS Bacterial cascade chemokine chemokines complement contributed controls coronavirus Coronavirus infection Critical cytokine Defense disease distress dysfunction effective exhibited fungal infections high-titer virus Host human infection identify immune Immune cell infiltration Infection Inflammatory cytokine inflammatory monocyte inhibiting intranasal investigated less lung Lung pathology mice mouse-adapted SARS-CoV neutrophil observation outbreak outcome outcomes Pathogenesis pathologic pathology pattern recognition receptor Proinflammatory response Protective reduced regulate relative Replication respiratory Respiratory disease respiratory viruses SARS-CoV SARS-CoV infection sera Severe case Signaling significantly stimulate subsequent syndrome systemic inflammation therapeutic These data Treatment Viral load weight loss [DOI] 10.1128/mBio.01753-18 PMC 바로가기 [Article Type] Research Article
Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose마이코박테리아의 세포 외피 스트레스는 트레할로스에 대한 반응으로 새로운 신호 전달 ATPase IniR에 의해 조절됩니다Research Article Published on 2017-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activator Affect assembly ATPase Author BAC bacterial cell biogenesis cascade Cell cell envelope cell wall complex compounds damaged defect domain domains drug ethambutol experiment explain exposure to family Gram-negative bacteria homologue identify include induce inducer integrity involved isoniazid latter gene Lipid lipids locus mechanism Mutagenesis mutant mutants mutations mycobacteria mycobacterial Mycobacterium operon overexpression pathway promoter PROTECT regulated Regulation regulator Regulatory regulatory gene respond RNAseq shown signal Signal transduction Signaling Stress stress response sugar sugars the cell transcriptional regulator transposon trehalose Tuberculosis understanding unique [DOI] 10.1371/journal.pgen.1007131 PMC 바로가기 [Article Type] Research Article
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans인간 진균 병원체 크립토코커스 네오포르만스에서 칼시뉴린-Crz1 스트레스 반응 전사 네트워크의 해명Research Article Published on 2017-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated appear ascomycete ascomycetes Aspergillus fumigatus binding calcineurin calcium calmodulin Candida albican Candida albicans cascade Cell cell wall cellular cna1 conserved contribute Control Cryptococcus neoforman Cryptococcus neoformans docking domain down-regulated downstream Evidence expression of gene Factor function functions fungal fungal pathogen fungal pathogens fungi high temperature involved majority motif mRNA mRNA expression mutant mutants nuclear translocation nucleus P-bodies P-body pathogen pathogenic Pathogens pathway phenotype Phenotypes pheromone phosphatase post-transcriptional levels predicted promote promoter promoter region promoter regions Protein regulate regulated regulatory network responses RNA-sequencing Saccharomyces cerevisiae Serine Signal transduction Signaling small molecule Stress stress granule stress granules stress response survival target target gene Target genes targets threonine Transcription transcription factor transcriptional Transport virulence wild-type [DOI] 10.1371/journal.pgen.1006667 PMC 바로가기 [Article Type] Research Article
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALSRetrotransposon 활성화는 ALS의 Drosophila TDP-43 모델에서 신경 퇴행에 기여합니다Research Article Published on 2017-03-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abnormality accompanied Activation aggregation ALS Amyotrophic lateral sclerosis Author cascade cause cell death cell types cells Characteristics contribute cytoplasmic de-repression death degeneration degenerative disease DNA DNA binding protein DNA damage Drosophila Effect Effects element event Evidence expressed expression Familial Genetic Genome Glia glial cells hallmark human disease impair impairment Inclusion incurable inhibiting Lateral Sclerosis lobar locomotor LTR majority mechanism Mutation neurodegeneration neurodegenerative disorder neurodegenerative disorders Neuron neuronal neurons nuclear protein pathology pathophysiological phenotype phenotypic Premature programmed cell death PROTECT Protein repression retrotransposon retrotransposons retrovirus reverse transcriptase RNA RNA silencing siRNA Small interfering RNA storm subset the disease tissue Toxicity transcriptase [DOI] 10.1371/journal.pgen.1006635 PMC 바로가기 [Article Type] Research Article
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다Research Article Published on 2017-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall [DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article
Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse CuesLrg1, Rho1 및 Pkc1을 통한 신호는 다양한 신호에 대한 응답으로 Candida albicans 형태 형성을 제어합니다Research Article Published on 2016-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Activation adenylyl cyclase allele Analysis blocked CAMP Candida Candida albican Candida albicans canonical cascade Cell cell growth concert Critical defined Deletion developmental disease downstream example form function functional fungal fungal pathogens Genetic growth GTPase healthy homozygous hosts Human humans hyphal identify Immunocompromised implicated inactive independent independent of Infection insertion invasive leads Lrg1 morphogenesis Morphological morphology mutant Mutation not impaired pathogen Pathogenesis Pathogens pathway positive promoted reduced regulate represse repression required response screened serum signaling pathway skin infections strain Strains transition transposon virulence yeast [DOI] 10.1371/journal.pgen.1006405 PMC 바로가기 [Article Type] Research Article
The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σ V Activation항-시그마 인자 RsiV는 리소자임에 대한 박테리아 수용체입니다: 공결정 구조 결정 및 RsiV에 대한 라이소자임의 결합이 σ V 활성화에 필요하다는 입증Research Article Published on 2016-09-072022-09-17 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence acting activate activated Activation active site addition Bacteria Bacterial bind binding cascade Cell cell wall cleavage cleave complex crystal structure Defense demonstrated demonstration Determination enzymatic activity enzyme Evidence Factor function functions Gram-positive bacteria inhibit inhibitor initiated innate immune lysozyme many case mutant promoter protease Proteases Protein proteolytic receptor regulated required resistance mechanisms RIP RNA polymerase sensor signal Signal transduction specificity Structure suggested susceptible Target genes the cell These data thought Trigger triggering triggers X-ray [DOI] 10.1371/journal.pgen.1006287 PMC 바로가기 [Article Type] Research Article
The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cellsResearch Paper: Immunology Published on 2016-03-152022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] Actin activating binding cascade cause cell membrane cofilin coronavirus decrease diarrhea disrupt downstream EGFR epidermal F-actin gastroenteritis growth factor GTPases high mortality Host immune response Immunity Immunology and Microbiology Section Infection inhibit inhibition intestinal epithelial cell intestinal epithelium involved MAPK mechanism Newborn Pathogenesis Phosphorylation PI3K platform promote Protein receptor regulate responsible Signaling signaling pathway Spike protein stimulate TGEV transmissible gastroenteritis virus upstream virus entry [DOI] 10.18632/oncotarget.7723 PMC 바로가기 [Article Type] Research Paper: Immunology
The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant HepatitisResearch Article Published on 2015-09-142022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activated Activation Acute inflammation ameliorated appear association benefit blocking cascade cause CD45 characterized clinical complex component Control deficiency Deletion disease Disease progression exacerbated excessive inflammation exhibited experiment expression Fgl2 fulminant Gr-1 Hepatic encephalopathy Hepatitis hepatocyte high mortality Host IL-1β inefficient Infection Inflammasome Inflammatory Inflammatory diseases Inflammatory response Intervention knowledge lack life-threatening limit liver Macrophage macrophages Mediated mice Mortality murine hepatitis virus NADPH Necrosis neutrophil neutrophil infiltration nicotinamide adenine dinucleotide NLRP3 NLRP3 inflammasome pathogen invasion Pathogenesis pathway phosphate Prevent Protein reactive oxygen specy recruitment reduce reduced reduction in reductions in Resilience responsible resulting ROS ROS production secretion serum severe disease severe liver disease Signaling signaling pathway subsequent subunit syndrome the disease treated Treatment viral infection virus infection virus replication wild-type [DOI] 10.1371/journal.ppat.1005155 PMC 바로가기 [Article Type] Research Article