An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responsesSARS-COV-2 특이 적 T 세포 반응을 결정하기위한 진단 도구로서 플루오 스팟 분석의 평가Research Article Published on 2021-09-302022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] addition Affect aligning Amino acid appear assays blood sample Blood samples calculated cellular Cellular immune response cellular immune responses cellular response Chain Reaction Cohort COVID-19 patients cross-reactive determine diagnostic diagnostic value dual endemic HCoVs evaluated HCoVs HCW healthcare worker Healthcare workers hospitalized COVID-19 patient house human coronavirus human coronaviruses IFN-γ IgG immune response immune responses individuals less nucleocapsid Numerous peptide peptide pool peptide pools polymerase chain polymerase chain reaction post infection reference standard Release repeated Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sensitivity Seroconversion serological serological assays serology seronegative Specificities specificity T cell T cell response [DOI] 10.1371/journal.pone.0258041 PMC 바로가기 [Article Type] Research Article
mRNA vaccination in people over 80 years of age induces strong humoral immune responses against SARS-CoV-2 with cross neutralization of P.1 Brazilian variant80세 이상의 사람들에서 mRNA 백신 접종은 P.1 브라질 변이체의 교차 중화와 함께 SARS-CoV-2에 대한 강한 체액성 면역 반응을 유도합니다Research Article Published on 2021-09-292022-09-10 Journal: eLife [Category] SARS, 변종, 진단, [키워드] age antibody Antibody Response Antibody responses BNT162b2 BNT162b2 mRNA vaccine Brazil Cellular immune response cellular response Cellular responses correlated COVID-19 COVID-19 vaccination cross detectable Donor dual effective Efficacy Human humoral humoral immune response Humoral immunity Humoral response immune responses immunosenescence induce Infection Mortality mRNA vaccination mRNA vaccine neutralization neutralization titer neutralization titers Older P.1 P.1 variant Pfizer platform reduced remained risk factor SARS-CoV-2 SARS-COV-2 infection second vaccination sera serological Spike protein Spike-specific cellular immune responses These data trials vaccination Vaccine vaccine response vaccine responses variant Victoria [DOI] 10.7554/eLife.69375 PMC 바로가기 [Article Type] Research Article
Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity?Case Report Published on 2021-09-272022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] Analysis antibody CCP Cellular immune response cellular immunity chronic chronic lymphocytic leukemia clinical recovery convalescent plasma coronavirus disease COVID-19 develop dosage Follow-up humoral Hypogammaglobulinemia immune response Immunological response in vitro T cell assay leukemia neutralizing antibody oxygen Patient performed provided repeated secondary serological test suffered time Treatment viral clearance with COVID-19 [DOI] 10.3390/idr13040077 PMC 바로가기 [Article Type] Case Report
Development of a Recombinant RBD Subunit Vaccine for SARS-CoV-2Article Published on 2021-09-262022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Cellular immune response COVID-19 development Emergency use Fc fragment fused fusion protein human IgG1 humoral IFN-γ IgG IL-10 IL-2 immunized mice induce mice monomer neutralizing antibody neutralizing epitopes Novel coronavirus pandemic Pneumonia Protein RBD RBD-Fc RBD-Fc fusion protein Receptor binding domain recombinant SARS-CoV-2 secretion significantly splenocyte subunit Subunit vaccine the S protein Vaccine vaccine candidate widespread [DOI] 10.3390/v13101936 PMC 바로가기 [Article Type] Article
Humoral and cellular immunity and the safety of COVID-19 vaccines: a summary of data published by 21 May 2021체액 및 세포 면역과 COVID-19 백신의 안전성: 2021년 5월 21일까지 발표된 데이터 요약Review Published on 2021-09-252022-09-11 Journal: International immunology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody caused Cellular immune response cellular immunity clinical Clinical data clinical study clinical trials consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deaths dissect Efficacy humoral immune responses indicated Isolation public health Rapid reactogenicity response safety profile SARS-CoV-2 severe acute respiratory syndrome Coronavirus T cell Vaccine Vaccine development variant viral genome sequence [DOI] 10.1093/intimm/dxab061 PMC 바로가기 [Article Type] Review
α-Hemolysin-Aided Oligomerization of the Spike Protein RBD Resulted in Improved Immunogenicity and Neutralization Against SARS-CoV-2 Variants스파이크 단백질 RBD의 α-헤몰리신 보조 올리고머화로 SARS-CoV-2 변이체에 대한 면역원성 및 중화가 개선됨Immunology Published on 2021-09-242022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Against alum alum adjuvant Antigen carrier protein Cellular immune response comparable confirmed COVID-19 case conformational conformational epitopes COVID-19 COVID-19 cases cross-protective demonstrated effective Epitopes immunization immunogenicity Improved increase in indicated kDa linear epitopes mHla-RBD molecular weight monomer neutralization activity Neutralizing activity Neutralizing antibodies neutralizing antibody oligomerization Protein pseudovirus Pseudovirus neutralization assay RBD RBD-specific antibodies RBD-specific antibody Safe SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants significantly increased specific antibodies Spike protein Subunit vaccine Th2 the RBD the Spike the spike protein Vaccine development Vaccines wild-type virus [DOI] 10.3389/fimmu.2021.757691 PMC 바로가기 [Article Type] Immunology
The Immune Response to SARS-CoV-2 and Variants of ConcernSARS-COV-2 및 관심의 변이에 대한 면역 반응Review Published on 2021-09-232022-09-10 Journal: Viruses [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Asymptomatic B cell Betacoronavirus Cellular immune response changes in concern coronavirus COVID-19 deaths Frequency humoral Humoral and cellular immune responses hyperinflammation immune protection immune response immune responses individual Infection Mild Mutation outbreak outcome pandemic Patient respiratory response resulting SARS-CoV-2 SARS-COV-2 infection several variant several variants severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease severe pneumonia Spread subsequent T cell T cell response Transmissibility vaccination Vaccine variants of concern Viral viral replication while Wuhan Wuhan, China [DOI] 10.3390/v13101911 PMC 바로가기 [Article Type] Review
Effects of Short-Term Corticosteroid Use on Reactogenicity and Immunogenicity of the First Dose of ChAdOx1 nCoV-19 Vaccine단기 코르티코스테로이드 사용이 ChAdOx1 nCoV-19 백신의 첫 번째 용량의 반응성 및 면역원성에 미치는 영향Comparative Study Published on 2021-09-222022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] anti-SARS-CoV-2 antibody BNT BNT162b2 Cellular immune response ChAdOx1 nCoV-19 Concentration Corticosteroid COVID-19 dose Effect electrochemiluminescence immunoassay evaluated first dose groups HCW HCWs healthcare worker IFN-γ immunogenicity interferon gamma interquartile range IQR low-dose corticosteroid median prednisolone equivalent Quantitative reactogenicity recruited reduce robust significantly significantly higher Spike protein statistical significance steroid total score vaccination Vaccine was measured [DOI] 10.3389/fimmu.2021.744206 PMC 바로가기 [Article Type] Comparative Study
Ex vivo SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses인간 폐의 생체 외 SARS-CoV-2 감염은 이질적인 숙주 방어 및 치료 반응을 나타냅니다Research Article Published on 2021-09-222022-09-10 Journal: JCI Insight [Category] SARS, 치료기술, 치료제, [키워드] animal models antiviral activity Biology bridge Cell cell line cell lines cell viability Cellular immune response Chloroquine clinical risk factor Clinical risk factors comparable COVID-19 COVID-19 infection COVID-19 pathogenesis cryobank CXCL8 Defense demonstrated detectable Dexamethasone Donor donors Drug screening Drug screens endothelial epithelial Ex vivo expression had no HCoV HCoV-OC43 heterogeneity heterogeneous heterogenous Host host response human infection human lung human lung tissue human SARS-CoV-2 IFNB1 IL6 Immune cell Infection Inflammation library mechanism metformin molecules N-hydroxycytidine OC43 Pathogens Population predicted preserved Remdesivir respiratory Respiratory pathogens reveal Sample SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Sirolimus subset suppressed susceptibility susceptibility to infection therapeutic response tissue tissues viability Viral viral growth viral replication [DOI] 10.1172/jci.insight.148003 PMC 바로가기 [Article Type] Research Article
Effect of SARS-CoV-2 mRNA vaccination in MS patients treated with disease modifying therapies질병 변형 요법으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 mRNA 백신 접종의 효과Observational Study Published on 2021-09-222022-09-12 Journal: EBioMedicine [Category] MERS, 임상, 진단, [키워드] Affect analyzed anti-CD20 therapy anti-CD20 treatment antibody antigens assessments Blood blood collection BNT162b2 BNT162b2 vaccine Cellular immune response contribute coronavirus correlated decrease detectable disease Effect electrochemiluminescence immunoassay elicit evaluate the effect finding Follow-up funding humoral immune response Immunomodulatory therapies interval Italian Linear regression Moderna mRNA vaccination mRNA vaccine mRNA-1273 mRNA-based SARS-CoV-2 vaccines multicenter cohort study Multiple multiple sclerosis multivariable multivariable analysis Patient patients treated reduced SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 vaccine sclerosis second dose serological assessment significantly the vaccine therapy untreated patients vaccination Vaccine vaccine dose Vaccines [DOI] 10.1016/j.ebiom.2021.103581 PMC 바로가기 [Article Type] Observational Study