An open labeled, randomized, controlled clinical study to evaluate the efficacy of Torchnil capsules and Febcin tablet as add-on therapy for Covid-19 patientsResearch article Published on 2022-04-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 바이오마커, 신약개발, 임상, [키워드] addition Admission assessment Biomarker Biomarkers CAP Cap. Torchnil clinical Clinical management clinical study Clinical symptoms clinically conducted COVID-19 CPK D-dimer Day discharge disease Effect effective Efficacy Efficacy and safety evaluate Evidence group Hospital stay IL-6 improvement LDH material moderate disease objective Oxygen requirements Patient patients with moderate physical positive patient Randomized receive Result Safe screened Standard of care Symptoms Tab. Febcin Tablet therapy WHO [DOI] 10.1016/j.jaim.2022.100559 [Article Type] Research article
Rationale and design of a study to assess the safety and efficacy of rNAPc2 in COVID-19: the Phase 2b ASPEN-COVID-19 trialRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: American heart journal [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] Anticoagulant appear assigned baseline bleeding blinded clinically Coagulation Coagulopathy Complete Concentration contribute COVID-19 D-dimer D-dimer level D-dimer levels Day discharge dose dose ranging Effect Efficacy elevated Endpoint Enrollment evaluate hospitalized COVID-19 patient IMPROVE in viral Infection Inflammation inflammatory signaling inhibitor Interaction limit Local nematode Open-label outcome outcomes participant patients hospitalized phase primary efficacy endpoint randomization Randomized Randomly rationale stratified subcutaneous injection Therapeutic approach therapeutic target thrombosis tissue Tissue Factor Trial viral propagation with COVID-19 [DOI] 10.1016/j.ahj.2021.12.010 PMC 바로가기 [Article Type] Randomized Controlled Trial
Bias as a source of inconsistency in ivermectin trials for COVID-19: A systematic review. Ivermectin’s suggested benefits are mainly based on potentially biased resultsResearch article Published on 2022-04-012022-10-05 Journal: Journal of clinical epidemiology [Category] COVID19(2023년), SARS, 임상, [키워드] approach benefit Bia bias certainty of evidence changed clinically conducted Coronavirus infections COVID-19 Effect enrolled estimate Evidence IMPROVE individual Intervention Ivermectin mechanical ventilation methodological limitations moderate Mortality not reduce objective outcome pairwise meta-analysis patients with COVID-19 performed platform Prophylactic random-effect randomized trial RCT RCTs reported Research Result risk of bia Risk of bias SARS-CoV-2 searched sensitivity analysis Standard of care suggested symptom resolution systematic review Treatment Trial viral clearance [DOI] 10.1016/j.jclinepi.2021.12.018 [Article Type] Research article
Metrics to relate COVID-19 wastewater data to clinical testing dynamicsCOVID-19 폐수 데이터를 임상 테스트 역학과 연관시키는 메트릭Article Published on 2022-04-012022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis applied changes in clinical testing clinically collected Concentration COVID-19 COVID-19 pandemic death disease spread Epidemiology events First wave help increase Massachusett Metrics MONITOR pandemic Pandemics public health Quantitative reported Reporting RNA concentrations RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA second wave Surveillance Temporal temporal dynamics time time lag transfer Treatment utility wastewater wastewater surveillance Wastewater-based epidemiology were measured while [DOI] 10.1016/j.watres.2022.118070 PMC 바로가기 [Article Type] Article
Convalescent plasma treatment in severely immunosuppressed patients hospitalized with COVID-19: an observational study of 28 casesObservational Study Published on 2022-04-012022-10-04 Journal: Infectious diseases (London, England) [Category] Coronavirus, COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome antibodies case sery cause CCP clinically convalescent convalescent plasma convalescent plasma treatment coronavirus COVID-19 COVID-19 infection decrease defined died Efficacy heterogeneous group Hospitalized hospitalized patient Immunocompromised patients immunosuppressed patient Immunosuppression In-hospital lymphoma pandemic Patient patients patients hospitalized PCR performed plasma Prospective randomized trial retrospective rituximab SARS-CoV-2 severe immunosuppression Severe infection standard treatment Study design symptom duration treated Treatment Treatment outcome Viremia Virological [DOI] 10.1080/23744235.2021.2013528 PMC 바로가기 [Article Type] Observational Study
Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection바이러스성 호흡기 감염에서 박테리아를 구별하기 위한 신속한 숙주 유전자 발현 검사의 전향적 검증Multicenter Study Published on 2022-04-012022-09-11 Journal: JAMA Network Open [Category] 유전자 메커니즘, 진단, [키워드] 95% CI absence acute COVID-19 acute respiratory illness age Analysis antibacterial therapy antibiotic ARI Asian Bacterial Bacterial infection black Care cause Characteristics children clinical clinically Cohort Concordance diagnostic Emergency Departments enrolled Enrollment entire cohort Ethnicity expression febrile female followed by group groups Hispanic Host host gene host gene expression host response IMPROVE individual IQR less likelihood male median age Messenger RNA multicenter Native Negative predictive value NPV offer outcome outcomes participant Participants pathogen Patient patients with ARI patients with COVID-19 performance Positive predictive value Predictive value primary analysis Probability procalcitonin Prospective quantified Rapid reported respiratory Respiratory illness resulting sensitivity specificity stratified Test the median validation Viral viral infection white with COVID-19 [DOI] 10.1001/jamanetworkopen.2022.7299 PMC 바로가기 [Article Type] Multicenter Study
Bacterial contamination of the smartphones of healthcare workers in a German tertiary-care hospital before and during the COVID-19 pandemicCOVID-19 대유행 전과 동안 독일 3차 병원 의료 종사자의 스마트폰 세균 오염Article Published on 2022-04-012022-09-12 Journal: American journal of infection control [Category] MERS, 진단, [키워드] addition age Analysis Bacteria Bacterial Bacterial contamination bacterial pathogen basic Basic hygiene behavioral change Clinical practice clinically collected conditions Contamination COVID-19 COVID-19 pandemic cross-contamination determine Device female Final handling HCW HCWs healthcare healthcare worker Healthcare workers Healthcare-associated infections hospital hygiene increase in intensity isolate less measure microbial MRSA Multidrug resistance multidrug-resistant pandemic profile proportion Randomly ranged resistance selected significant increase significantly Smartphone Staphylococcus aureus Study design susceptibility Touchscreen [DOI] 10.1016/j.ajic.2021.09.025 PMC 바로가기 [Article Type] Article
Association of Subcutaneous or Intravenous Administration of Casirivimab and Imdevimab Monoclonal Antibodies With Clinical Outcomes in Adults With COVID-19카시리비맙 및 임데비맙 단클론항체의 피하 또는 정맥내 투여와 COVID-19가 있는 성인의 임상 결과와의 연관성Article Published on 2022-04-012022-09-12 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI adjusted administer Administered administration Admission adverse events age antibody association Casirivimab clinical clinically cohort study Control control group COVID-19 death decrease eligible eligible patient Emergency use authorization end point evaluate evaluated Evidence expand health system Hospitalization Imdevimab injection intensive care intravenous mAb mechanical ventilation Mild moderate Moderate COVID-19 no difference outcome Outpatient Patient patients patients treated Primary outcome prospective cohort study randomized clinical trial reduced risk risk ratio secondary single dose statistically Subcutaneous subcutaneous administration subcutaneously Symptom Symptoms Treatment women [DOI] 10.1001/jamanetworkopen.2022.6920 PMC 바로가기 [Article Type] Article
Chronic Fatigue and Postexertional Malaise in People Living With Long COVID: An Observational StudyObservational Study Published on 2022-04-012022-10-05 Journal: Physical therapy [Category] 임상, [키워드] affected Analysis assessment characterized chronic Chronic fatigue clinical conditions Clinical practice clinically COVID COVID-19 cross-sectional survey data cleaning exercise Exercise Tolerance fatigue help illness indicate Infection Intervention Long Long COVID malaise participant Participants Patient Patient-reported outcomes physical activity Physical therapist Quality of life questionnaire recommendations rehabilitation reported scale Self-management severe fatigue severity Symptom symptom burden syndrome the patient threshold [DOI] 10.1093/ptj/pzac005 PMC 바로가기 [Article Type] Observational Study
In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs임상적으로 이용 가능한 약물의 표적으로서 SARS-CoV-2 단백질의 in silico 분석Article Published on 2022-03-292022-09-11 Journal: Scientific Reports [Category] Coronavirus, SARS, 신약개발, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amprenavir Analysis avanafil binding binding site calcipotriol caused cells clinically Compound coronavirus develop disease docked docking domain Domperidone drug FDA-approved drug FDA-approved drugs filtered framework had no Huh-7 human liver identify in vitro involved levomefolic acid Mac1 moderate molecular dynamics Molecular dynamics simulation molecular dynamics simulations Nintedanib non-structural protein NSP Nsp15 nucleocapsid protein pandemic predicted provide reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus small molecule small molecule drug small molecule drugs Spike protein target target proteins targets the spike protein Treatment Viral RNA Virtual screening [DOI] 10.1038/s41598-022-08320-y PMC 바로가기 [Article Type] Article