Monitoring SARS-CoV-2 Populations in Wastewater by Amplicon Sequencing and Using the Novel Program SAM RefinerArticle Published on 2021-08-192022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Amplicon Amplicon sequencing analyses B.1 B.1.1.7 chimeric computation coronavirus coronavirus 2 D614G domain function Gamma metagenomics Molecular epidemiology monitoring novel P.1 PCR polymerase chain Population Program respiratory SAM SARS-CoV-2 SARS-CoV-2 spike sequencing method Spread variant variants of concern variety viral population dynamics Viral variants wastewater [DOI] 10.3390/v13081647 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in people living with and without HIV in South Africa: an interim analysis of a randomised, double-blind, placebo-controlled, phase 1B/2A trial남아프리카에 HIV가 있거나없는 사람들의 SARS-COV-2에 대한 Chadox1 NCOV-19 (AZD1222) 백신의 안전성 및 면역 원성 : 무작위, 이중 맹검, 위약 대조, Phase 1B/2A 시험의 중간 분석Clinical Trial Published on 2021-08-172022-08-13 Journal: The Lancet. HIV [Category] MERS, SARS, 변종, 임상, 진단, [키워드] 1:1 1B/2A trial 95% CI adverse event adverse events African Alanine alanine aminotranferase allocation concealment Antibody Response Antibody Units Antiretroviral therapy Asp614Gly wild-type AZD1222 B.1.351 baseline Beta Beta variant binding antibodies binding antibody unit booster booster response both groups ChAdOx1 ChAdOx1 nCov 19 ChAdOx1 nCoV-19 clinical COV005 criteria cross-reactive binding antibodies cross-reactive binding antibody cross-reactivity D614G demonstrated died domain dose double-blind elevated eligibility criteria enrolled enrolment Fever finding FIVE foundation full-length funding geometric mean geometric mean concentration GMC high responder high responders High-level binding antibody HIV HIV-negative hospital IgG responses immunogenicity in both groups increased risk individual individuals Innovation interim analysis Intervention less Medical Research Council Melinda Gate Melinda Gates n=36 nCoV neutralisation Neutralising activity outcome Pan participant Participants people with HIV person with HIV Placebo placebo-controlled plasma Primary immunogenicity analyses Primary immunogenicity analysis prime-boost regimen priming priming dose randomised Randomly reactogenicity receive Receptor-binding domain Registered registry responses responses against retained rising Safety SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens Serious Adverse Events seronegative seropositive serum IgG Seven severe COVID-19 South South Africa titre Trial unlikely Vaccine vaccine dose Viral Viral load wild-type wild-type Wuhan-1 Asp614Gly with HIV [DOI] 10.1016/S2352-3018(21)00157-0 PMC 바로가기 [Article Type] Clinical Trial
Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal AntibodiesImmunology Published on 2021-08-172022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] A475V Amino acid antigenicity convalescent convalescent plasma cross-neutralization crucial mutation D614G evaluated humoral immune response identify Immune escape Lineage mAb mAbs monoclonal antibody mutant Mutation neutralization plasmas pseudoviruses resulting SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 pseudovirus SARS-CoV-2 variant sensitivity spike Spike protein strain the spike protein [DOI] 10.3389/fimmu.2021.693775 PMC 바로가기 [Article Type] Immunology
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection헤스페리딘은 SARS-CoV-2 감염에 대한 잠재적 억제제입니다Article Published on 2021-08-162022-09-10 Journal: Nutrients [Category] MERS, SARS, 변종, [키워드] 501Y.V2 ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aglycone angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bioavailability cellular cellular entry cellular receptor coronavirus D614G docking hesperetin hesperidin Infection Interaction metabolite Particles Potential Proteins reducing reduction required respiratory S protein SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus shown suppressed the S protein the SARS-CoV-2 TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor transmembrane serine protease transmembrane serine protease 2 variants variants of SARS-CoV-2 VeroE6 cell VeroE6 cells wild type [DOI] 10.3390/nu13082800 PMC 바로가기 [Article Type] Article
Molecular Dynamics Studies on the Structural Characteristics for the Stability Prediction of SARS-CoV-2SARS-CoV-2의 안정성 예측을 위한 구조적 특성에 관한 분자 역학 연구Review Published on 2021-08-132022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, [키워드] 3D structure ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis bind binding free energy binding free energy calculation conformational coronavirus COVID-19 pandemic D614G domain Dynamics fluctuation form forms free energy global pandemic human ACE2 human cell human cells Interaction investigated involved Korean L455F MD simulation mutant mutants patients performed prediction prevalent Protein RBD RBD region released respiratory Respiratory system S2 domain SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein stability the RBD variant wild type [DOI] 10.3390/ijms22168714 PMC 바로가기 [Article Type] Review
Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivoArticle Published on 2021-08-122022-10-04 Journal: Cell Discovery [Category] 변종, 치료제, [키워드] ACE2 ACE2-Fc addition antiviral effects B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta bind blocked catalytic activity caused COVID-19 pandemic D614G Delta dose-dependent efficacy entry of SARS-CoV-2 enzyme escape mutants functional fusion protein hACE2 hACE2-expressing cell HCoV-NL63 histological changes immunology in vivo indicated induce infections Inflammation inhibited Lungs Mechanisms of disease mice mutant mutations neutralized Neutralizing antibodies potent Prophylactic prophylactic treatment Prophylaxis Protein provided public health threat RBD receptor Receptor binding domain reduced SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variants soluble ACE2 therapeutic therapeutic efficacy therapy for COVID-19 Treatment V367F viral replication weight loss [DOI] 10.1038/s41421-021-00302-0 PMC 바로가기 [Article Type] Article
Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples GloballyArticle Published on 2021-08-102022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] A570D acute respiratory syndrome Alpha Alpha variant amino acid substitution Analysis analyzed B.1 B.1.1 B.1.1.7 China circulating Community Contamination coronavirus country COVID-19 COVID-19 case Czech Republic D614G detect Epidemiology Genetic genomic Germany GISAID highest Human Italy Lineage Mutation Netherlands Other Outbreaks P681H pandemic percentage Phylogenetic analysis prevalent lineage Prevent recorded reported S982A Sample SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 virus sequence sewage Slovenia Spike protein strain Surveillance Switzerland T716I Treatment variant virus genome wastewater [DOI] 10.3390/microorganisms9081696 PMC 바로가기 [Article Type] Article
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York뉴욕에서 SARS-CoV-2 계통 B.1.526의 탐지 및 특성화Article Published on 2021-08-092022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] A701V Affect appear B.1.1.7 B.1.526 city concert convalescent COVID-19 case COVID-19 cases Critical D614G demonstrated detect detection develop E484K Epidemiology examination experiment growth Lineage Mutation neutralization neutralization titer New York other variants pandemic plasma public health reported S477N SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequencing SARS-CoV-2 genomes second wave sequenced Software spike spike mutation spike mutations Spread the SARS-CoV-2 vaccinee variants Viral viral evolution viral infection West [DOI] 10.1038/s41467-021-25168-4 PMC 바로가기 [Article Type] Article
Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in WastewaterSARS-CoV-2 실시간 역학 및 폐수의 심층 돌연변이 프로파일링을 위한 새로운 Nested-Seq 접근 방식Article Published on 2021-08-072022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] (RdRp 2019-nCoV Alpha variant amplification Analysis applied approach caused clinical sample clinical samples Combination COVID-19 D614G DNA sequencing effective Epidemiology Frequency genomic variants indicated lack Modification Molecular assay National nested PCR novel P323L pandemic PCR assays platform predicted Prevalence Profiling quantification RdRP Real-time monitoring Region regions reverse transcription RNA stability SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 NGS SARS-CoV-2 RNA SARS-CoV-2 sequencing SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sequencing data sewage significantly Spike protein Treatment variant variants wastewater Wastewater-based epidemiology with COVID-19 [DOI] 10.3390/ijms22168498 PMC 바로가기 [Article Type] Article
Near-Complete Genome Sequences of Nine SARS-CoV-2 Strains Harboring the D614G Mutation in MalaysiaGenome Sequences Published on 2021-08-052022-10-29 Journal: Microbiology Resource Announcements [Category] COVID-19, [키워드] acute respiratory syndrome addition B.1.351 Complete coronavirus D614G D614G mutation described genome sequence infected individual Lineage Local Malaysia nine SARS-CoV-2 sequence severity strain These viruses variant variants VoC [DOI] 10.1128/MRA.00657-21 PMC 바로가기 [Article Type] Genome Sequences