endothelial – Page 22 – Communicable Diseases Research

EASIX for Prediction of Outcome in Hospitalized SARS-CoV-2 Infected Patients

입원한 SARS-CoV-2 감염 환자의 결과 예측을 위한 EASIX

Immunology

Published on 2021-06-232022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커,

SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19

SARS-COV-2는 주요 내피 인테그린 αVβ3을 사용하여 COVID-19 동안 혈관 조절 조절을 유발합니다.

Research Article

Published on 2021-06-232022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS,

[키워드] accelerate Anti-viral binding site bloodstream Candidates cardiovascular complications Characteristics cilengitide COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic dysregulation Effect effort ENCODE endothelial endothelial cells Endothelium epithelium etiological expressed Final Host host protein in viral in-silico In-vitro infection rate integrin Integrins Interaction International leakage microbial motif Mutagenesis pathogen pathogenicity reproductive SARS-CoV-2 Spike protein Transmissibility unique Vascular vascular endothelial cell vascular endothelial cells vasculature Viral viral propagation
[DOI] 10.1371/journal.pone.0253347 PMC 바로가기 [Article Type] Research Article

He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic Study

Pharmacology

Published on 2021-06-182022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory distress syndrome adjuvant Analysis ARDS Bupleurum can be used CCL2 Chinese Clinical efficacy Clinical practice combination therapy component composed conducted coronavirus disease Coronavirus disease 2019 COVID-19 Cytoscape Decoction Effect endothelial Fever GeneCard Glycyrrhiza uralensis growth factor he-jie-shen-shi decoction IL1B Inflammatory response inheritance inhibiting viral replication involved KEGG Kyoto Ligand Lung injury Man MAPK MAPK signaling MAPK3 mechanism mechanisms Medicine monotherapy Necrosis Negative conversion network network pharmacology nine notable nucleic acid oxidative stress p53 pathway Pathways Patient Pharmacology Pinellia ternata Potential PPI predict Protein Protein–protein interaction PTGS2 receptor required Result retrospective cohort study screened Scutellaria baicalensis selected severe COVID-19 shown suggested syndrome System T cell receptor target TCMSP therapeutic therapy TNF Toll-like receptor Tongji Hospital TP53 Traditional Traditional Chinese medicine treat Vascular VEGF VEGFA Wuhan
[DOI] 10.3389/fphar.2021.700498 PMC 바로가기 [Article Type] Pharmacology

Viral Bad News Sent by EVAIL

Review

Published on 2021-06-182022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19

Pharmacology

Published on 2021-06-172022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] accelerate activated addition adhesion molecules Aggravated Angiotensin II angiotensin receptor blocker Antihypertensive treatment Antithrombotic approach atherosclerotic cardiovascular comorbidities caused Cell chemokine chronic inflammation Coagulation contribute COVID-19 cross-talk Cytokine storm Cytokines disease drug drugs endothelial Endothelial dysfunction Endothelium enzyme Evidence exhibit experimental evidence favor haemostasis High-risk patients hypertension Impact impair Inflammation Inflammatory inhibitor mechanism mediators of inflammation outbreak patients with COVID-19 phenotype Prognosis proinflammatory Protective prothrombotic state raised reactive oxygen species reduce renin-angiotensin-aldosterone system significantly Stress subject subsequent System thrombin thrombotic complication tissue tissue damage up-regulated Vascular vascular disease vascular smooth muscle vessel wall
[DOI] 10.3389/fphar.2021.640185 PMC 바로가기 [Article Type] Pharmacology

Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19

Review

Published on 2021-06-172022-10-28
Journal: The Cochrane database of systematic reviews [Category] COVID-19,

[키워드] Acute kidney injury addition adjuvant Ageusia analyzed Anosmia anti-vascular antioxidant antioxidants brain tissue cause caused cellular Central nervous system change clinical manifestation Complication contribute coronavirus 2 cough CoV infection COVID-19 death disease disorders distress drugs endothelial fatigue Fever Growth factors headache immunomodulators Infectious disease Inflammation Injury liver dysfunction modulating myalgias neuro-therapeutic management Neuroinvasive Neurological complication neurological damage neurological manifestation Neurological symptom oxidative stress respiratory SARS-CoV-2 Seizures specific treatment suggested Supportive treatment Symptom syndrome the disease Treatment Vaccine with COVID-19
[DOI] 10.3390/antiox10060971 PMC 바로가기 [Article Type] Review

Revealing the therapeutic targets and molecular mechanisms of emodin-treated coronavirus disease 2019 via a systematic study of network pharmacology

네트워크 약리학에 대한 체계적인 연구를 통해 2019 년 에모딘 처리 된 코로나 바이러스 질병의 치료 표적 및 분자 메커니즘을 드러냅니다.

Research Paper

Published on 2021-06-152022-09-10
Journal: Aging (Albany NY) [Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 B-cell B-cell lymphoma Bacterial BCL2L1 bioinformatics Biomarker Biomarkers Cancer candidate gene CASP3 caspase caspase-3 colony stimulating factor complications coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 CSF2 CXCL8 developmental Diabetic diabetic complications docking Effect EGFR emodin endothelial epidermal epidermal growth factor exhibited Factor GO analysis growth factor IL-17 IL1B Infection interleukin interleukin-8 involved KEGG leads lipopolysaccharide MAPK MAPK signaling MAPK1 MAPK14 MCL1 mitogen mitogen-activated protein kinase molecular molecular docking molecular mechanism molecular mechanisms molecule myeloid cell Necrosis network pharmacology pathway Pathways pertussis pharmacological pharmacological mechanism pharmacological target Protein protein kinase Proteoglycan proteoglycans PTGS2 RAGE receptor receptor signaling reproduction reproductive respiratory screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown signaling pathway suggested target targets therapeutic target TNF TNF signaling TP53 treating COVID-19 Treatment treatment of COVID-19 Tumor tumor necrosis tumor necrosis factor Vascular VEGFA
[DOI] 10.18632/aging.203098 PMC 바로가기 [Article Type] Research Paper

SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity

Cardiovascular Medicine

Published on 2021-06-112022-10-31
Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19,

[키워드] ACE2 acute respiratory syndrome Affect affected angiotensin converting enzyme Angiotensin converting enzyme-2 Artery association barrier Brain C57BL/6 Cell cell type cells coronavirus coronavirus disease COVID-19 Culture Degradation Diabetic downregulating endocytic endothelial endothelial barrier function Endothelial cell endothelial cells endothelial damage Evidence experiment expression function greater in vitro individuals integrity investigated junctional proteins mice mouse oxidative damage Patient PROTECT Protein receptor SARS-CoV-2 SARS-CoV-2 spike protein significantly spike Symptom Transwell Treatment Vascular Vascular damage were used
[DOI] 10.3389/fcvm.2021.687783 PMC 바로가기 [Article Type] Cardiovascular Medicine

Comparison of renal histopathology and gene expression profiles between severe COVID-19 and bacterial sepsis in critically ill patients

중증 코로나19와 중증 환자의 세균성 패혈증 사이의 신장 조직병리 및 유전자 발현 프로파일 비교

Research

Published on 2021-06-102022-09-11
Journal: Critical Care [Category] MERS, 유전자 메커니즘, 치료제,

[키워드] ACE2 mRNA Activation Acute kidney injury acute tubular necrosis AKI AKI patient Analysis angiopoietin Bacterial Bacterial sepsis biopsy cadherin CD31 Cohort collected Control tissue controls COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient death detect determine disease onset downregulated driving endothelial endothelial integrity Extensive feature Fold change gene expression profile histopathological Histopathology ICU ICU admission individual Inflammation Injury involved kidney lack lung tissue marker mechanism Microvascular thrombosis mRNA mRNA expression mRNA level mRNA levels normal not differ observation pathophysiological Patient patients patients with COVID-19 PCR positive peritubular renal renal tissue required Result SARS-CoV-2 RNA Sepsis severe COVID-19 supplementary material the timing thrombi thrombosis tissue total nephrectomy Tubular Necrosis VE-cadherin was obtained
[DOI] 10.1186/s13054-021-03631-4 PMC 바로가기 [Article Type] Research

Endothelial glycocalyx shields the interaction of SARS-CoV-2 spike protein with ACE2 receptors

Article

Published on 2021-06-092022-10-29
Journal: Scientific Reports [Category] COVID-19,