Determination of the characteristic inactivation fluence for SARS-CoV-2 under UV-C radiation considering light absorption in culture mediaArticle Published on 2021-07-272022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Affect Analysis applied Applied optics Biophysics carried characteristic condition Critical Culture culture media Determination distribution dose Eagle evaluate experiment functions help inactivation optical pathogen Radiation robust SARS-CoV-2 survival variety virus [DOI] 10.1038/s41598-021-94648-w PMC 바로가기 [Article Type] Article
The Good and Bad of Nrf2: An Update in Cancer and New Perspectives in COVID-19Nrf2의 좋은 점과 나쁜 점: 암의 업데이트와 COVID-19의 새로운 관점Review Published on 2021-07-262022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] Activation anti-inflammatory response Anti-viral antioxidant broad spectrum Cancer Cell cell death cell fate complex coronavirus disease correlation COVID-19 COVID-19 treatment Cytokine storm described disease dissect Enzymes erythroid Factor functions genes encoding Good implicated Inflammation molecular New NF-κB Nrf2 occur overstimulation oxidative stress oxidative stress response progression protective role recent finding stress response transcription factor Treatment viral infections widespread [DOI] 10.3390/ijms22157963 PMC 바로가기 [Article Type] Review
Smart City and Crisis Management: Lessons for the COVID-19 PandemicReview Published on 2021-07-212022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] adverse effect Analysis catastrophic city Community community well-being COVID-19 COVID-19 pandemic crisis crisis management Critical Digital literacy dissemination Effect ENhance exclusion functional functions inefficient lesson literature review maintain management media mental health mitigate monitoring systems MOST physical Planning recommendation Research Resilience Side effects SmaRT smart city suggested technology urban resilience [DOI] 10.3390/ijerph18157736 PMC 바로가기 [Article Type] Review
Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteinsSARS-CoV-1 및 SARS-CoV-2 단백질에 의한 상피 나트륨 채널 활성 조절Article Published on 2021-07-202022-09-11 Journal: Biophysical Journal [Category] SARS, 유전자 메커니즘, [키워드] Acetate Acetylcholine acetylcholine receptor Activation acute respiratory syndrome Affect Alter cause co-injection combinations competition coronavirus Coronavirus 2019 coronavirus disease Coronavirus disease 2019 CoV CoV proteins decrease E protein Effect ENCODE envelope epithelial epithelial sodium channel experiment expressed function functional expression functions furin furin cleavage site Human plasma Hypothesis Immunoblots inhibitor injected injection Interaction mammalian mechanisms membrane molecular mRNA mRNAs nine occur Oocyte oocytes ORF8 pathophysiology phorbol phorbol 12-myristate phorbol 12-myristate 13-acetate PKC plasma membrane produced protease Protein protein kinase protein kinase C Proteins receptor reduce reduced S protein S proteins SARS protein SARS-CoV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 S SARS-CoV-2 S protein Severe acute respiratory syndrome significantly sodium sodium channel tested the S protein the SARS-CoV-2 Xenopus oocytes [DOI] 10.1016/j.bpj.2021.06.005 PMC 바로가기 [Article Type] Article
The Influence of Virus Infection on Microglia and Accelerated Brain AgingReview Published on 2021-07-202022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] accelerate accelerated Affect aging Brain brain aging Central nervous system contribute deficiency disease Evidence flavivirus functions Health herpes viruses HIV human herpes virus immune Immune cell induce Inflammatory influence Influenza interfere microglia Neuroinflammation neurotropic neurotropic virus physiological remodeling processes SARS-CoV-2 viral infection virus [DOI] 10.3390/cells10071836 PMC 바로가기 [Article Type] Review
Dynamics of the SARS-CoV-2 nucleoprotein N-terminal domain triggers RNA duplex destabilizationSARS-CoV-2 핵단백질 N-말단 도메인의 역학은 RNA 이중체 불안정화를 유발합니다Article Published on 2021-07-202022-09-11 Journal: Biophysical Journal [Category] SARS, 치료법, [키워드] 1:1 stoichiometry acute respiratory syndrome acute respiratory syndrome coronavirus Arm Betacoronavirus betacoronaviruses binding coronavirus dimeric double-stranded driven by dsRNA dsRNAs Dynamics functions information interact MD simulation MD simulations molecular molecular dynamics monomeric N protein N-terminal domain nonspecific nucleocapsid Protein raising Regulatory responsible RNA severe acute respiratory syndrome Coronavirus Support the SARS-CoV-2 Transcription transcriptional regulatory sequence Trigger triggering TRS viral genome [DOI] 10.1016/j.bpj.2021.06.003 PMC 바로가기 [Article Type] Article
Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 PatientsMicrobiology Published on 2021-07-192022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 16S rRNA gene 95% CI Analysis association Bacteria C-reactive protein changes in clinical clinical parameter Clinical severity conducted coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity cross-sectional demonstrated Diversity Dysbiosis functions Gut gut microbiota gut microbiota composition Hospitalized hospitalized patient Host immune Inflammatory intensive care investigated Isolation microbial microbiota mild COVID-19 patients moderate multicenter multivariable logistic regression Multivariable regression analysis prognostic biomarker risk factor scale Sequencing severe COVID-19 Severe patient severity Shannon—Weiner diversity index the WHO was performed WHO Clinical Progression Scale [DOI] 10.3389/fmicb.2021.705020 PMC 바로가기 [Article Type] Microbiology
The Use of CytoSorb Therapy in Critically Ill COVID-19 Patients: Review of the Rationale and Current Clinical ExperiencesReview Article Published on 2021-07-172022-10-31 Journal: Critical Care Research and Practice [Category] COVID-19, [키워드] accumulating Blood purification clinical conditions contribute COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Critically ill current Cytokine release syndrome cytokine removal Cytokine storm dysregulated Effect Evidence experience functions Health hemoadsorption hemodynamic host response hyperinflammation Hyperinflammatory Ill Intervention investigated Mortality organ pathophysiological patients platform rationale review turn [DOI] 10.1155/2021/7769516 PMC 바로가기 [Article Type] Review Article
The Role of High-Density Lipoprotein in COVID-19Pharmacology Published on 2021-07-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] abnormal coagulation acutely ill patient Analysis angiotensin-converting enzyme 2 anti-apoptotic antioxidant binding change Characteristics cholesterol clinical complications Coronavirus disease 2019 correlated COVID-19 death disease severity dysregulated immune response Effects Evidence Fatality rate functions HDL high-density Inflammatory response lipoprotein Lipoproteins LPS managing mechanism Mortality multiple-organ failure neutralize pandemic pathogenesis of COVID-19 pathophysiological pathophysiological feature Patient patients with COVID-19 pleiotropic reducing Regulation role SARS-CoV-2 severe COVID-19 significantly therapy Transport unique [DOI] 10.3389/fphar.2021.720283 PMC 바로가기 [Article Type] Pharmacology
Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2SARS-CoV-2의 ORF3a 단백질의 미스센스 돌연변이의 병원성 관점Article Published on 2021-07-152022-09-11 Journal: Virus research [Category] SARS, 변종, 치료기술, [키워드] Amino acid among others Cluster coded Complete coronavirus COVID-19 COVID-19 pathogenesis Critical disease Effect function functions Genetic variations Genome include ion channel K-means clustering knowledge life-threatening Missense mutation Missense mutations morphogenesis Mutation mutations NCBI database Neutral Non-synonymous mutation ORF3 ORF3a ORF3a protein pathogenic pathogenicity Perspective Protein SARS-CoV-2 SARS-CoV-2 genome Shannon entropy stability the SARS-CoV-2 genome timeline virulence virus [DOI] 10.1016/j.virusres.2021.198441 PMC 바로가기 [Article Type] Article