Optimal Drug Regimen and Combined Drug Therapy and Its Efficacy in the Treatment of COVID-19: A Within-Host Modeling Study최적의 약물 요법과 복합 약물 요법과 COVID-19 치료의 효능: 숙주 내 모델링 연구Article Published on 2022-05-192022-09-11 Journal: Acta biotheoretica [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered administration Arbidol average basic reproduction number Cell Combination combination therapies combination therapy Combined Comparative Comparative effectiveness study COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 pathogenesis death drug Drug interventions drugs Effectiveness Efficacy help include infected cells infection-related mortality Inflammatory mediators interferon Intervention life-threatening Lopinavir Lopinavir/ritonavir mathematical medical intervention modeling number of infected Optimal control problem Optimal drug Regimen physician reduce regimen Remdesivir Ritonavir significantly Stage susceptible cell Treatment treatment of COVID-19 Viral load were used [DOI] 10.1007/s10441-022-09440-8 PMC 바로가기 [Article Type] Article
Immune Response 5-7 Months after Vaccination against SARS-CoV-2 in Elderly Nursing Home Residents in the Czech Republic: Comparison of Three Vaccines체코의 노인 요양원 거주자의 SARS-CoV-2 예방 접종 후 5-7개월의 면역 반응: 3가지 백신의 비교Article Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval anti-S IgG antibody appear approach AstraZeneca booster dose cellular cellular immunity completion complex convalescent correlated Course COVID-19 elderly elderly nursing home residents evaluated expected home Humoral immunity IgG antibodies IgG antibody immune parameter immune response Immunity individual interferon matter Moderna Month neutralization capacity nucleocapsid protein Nursing nursing home occurred omicron participant patients Pfizer positive positive result Prevalence resident response Result sampling SARS-CoV-2 SARS-COV-2 infection significantly higher Spike protein subset tested titer took place vaccination Vaccine Vaccines Virus neutralization was reduced [DOI] 10.3390/v14051086 PMC 바로가기 [Article Type] Article
[Immune response against the severe acute respiratory syndrome coronavirus 2]Article Published on 2022-05-152023-07-09 Journal: Orvosi hetilap [Category] COVID19(2023년), [키워드] adaptív immunitás Adaptive immunity antibodies B and T cell memory B- és T-sejt-memória citokinek Cytokines ellenanyagok Innate immunity interferon természetes immunitás. [DOI] 10.1556/650.2022.32521
Intracellular mono-ADP-ribosyltransferases at the host–virus interphaseReview Published on 2022-05-102023-08-30 Journal: Cellular and Molecular Life Sciences [Category] E형 간염, [키워드] ADP-ribosylation alphavirus Chikungunya virus coronavirus hydrolase interferon macrodomain MARylation PARP Pattern recognition receptors Signaling [DOI] 10.1007/s00018-022-04290-6 PMC 바로가기 [Article Type] Review
Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity장기 allo-HSCT 생존자에서 백신 접종 후 SARS-CoV-2 T-세포 반응의 결핍은 체액성 면역 감소로 해석됩니다Article Published on 2022-05-102022-09-11 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation Amino acid analyzed anti-RBD BNT162b2 Control coronavirus COVID-19 COVID-19 vaccines death deficiency detectable determine disease Ex vivo Fisher Fisher's exact test healthy control hematological Hematopoietic stem cell HSCT Humoral immunity humoral responses IgG immunogenicity Immunoglobulin Immunoglobulin G interferon interferon-γ lack median mRNA mRNA-1273 Odds ratio of BNT162b2 overlap Patient peptide peptides rate of seroconversion RBD reactivity Receptor binding domain recipient recipients reflected respiratory risk S1 IgG SARS-CoV-2 second vaccination Seroconversion seronegative serum severe acute respiratory syndrome Coronavirus severe disease significantly lower stem cell Stem cell transplantation stimulated substandard survivor T-cell T-cell immunity T-cell Response T-cell responses translate transplantation vaccination Vaccinations vaccine dose Whole blood [DOI] 10.1182/bloodadvances.2021006937 PMC 바로가기 [Article Type] Article
The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune responseSARS-CoV-2 감염 동안 lncRNA, RNA 결합 단백질 및 바이러스 게놈 사이의 상호 작용은 RNA 대사 및 면역 반응과 관련된 조절 사건과의 강력한 연결을 보여줍니다Article Published on 2022-05-092022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] analyzed association BISPR Cell cellular cellular response characterized Cohort cohort of patient Combination complex component composed connection coronavirus Correlation analysis Defense defense mechanisms determine element event experimental evidence FMR1 FMR1-IT1 functional Host host cells human host cell human host cells human RNA identify immune response in silico infected cell Infection infectious agent Interaction interactions interferon interferon response intrinsic involved lncRNA long non-coding RNA mechanism metabolism MIR155HG modulate molecular ncRNAs Non-coding RNAs NRIR performed progression Protein rationale Regulation Regulatory regulatory network regulatory network. replicative reveal RNA RNA viruses RNA-binding protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load sequestering Specific Surveillance the interferon transcriptional transcriptomic triggered USP30 USP30-AS1 Viral viral genome viral infections viral RNA genome [DOI] 10.7150/thno.73268 PMC 바로가기 [Article Type] Article
High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 PatientsHERV-K(HML-2)의 높은 발현은 COVID-19 환자에서 인터페론을 자극할 수 있습니다Article Published on 2022-05-072022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activate activated Affect antiviral immunity blood sample Blood samples Cell cGAS chromosome collected COVID-19 COVID-19 patient COVID-19 patients distribution expressed expression Gene ontology Genes GO analysis healthy healthy controls HERV HERV-K HERV-K (HML-2) HML-2 Host human body IFIT1 IFN-I IFNB1 infected with SARS-CoV-2 Interaction interferon ISG15 mapped marker Next-generation sequencing pathway Patient qPCR regulate SARS-CoV-2 secretion STING Vero Vero cells was performed [DOI] 10.3390/v14050996 PMC 바로가기 [Article Type] Article
Longitudinal T-Cell Responses After a Third SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis on Ocrelizumab or FingolimodOcrelizumab 또는 Fingolimod에 대한 다발성 경화증 환자의 세 번째 SARS-CoV-2 예방 접종 후 세로 T 세포 반응Multicenter Study Published on 2022-05-062022-09-11 Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added additive effect boost comparable coronavirus declined evaluate evaluated fingolimod had no healthy control healthy controls immune-mediated diseases induce interferon lead longitudinal median multicenter Multiple multiple sclerosis Ocrelizumab Patient patients respiratory response SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells SARS-CoV-2-specific T-cell response sclerosis second vaccination secreting severe acute respiratory syndrome Coronavirus T cells T-cell Response T-cell responses therapy treated vaccination Vaccinations [DOI] 10.1212/NXI.0000000000001178 PMC 바로가기 [Article Type] Multicenter Study
Dynamic Changes of Cytokine Profiles and Virological Markers Associated With HBsAg Loss During Peginterferon Alpha-2a Treatment in HBeAg-Positive Chronic Hepatitis B PatientsArticle Published on 2022-05-042023-06-13 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Chronic Hepatitis B cytokine functional cure hepatitis B surface antigen interferon [DOI] 10.3389/fimmu.2022.892031 PMC 바로가기
Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences인도-아프리카 서열을 기반으로 하는 EDIII-NS1 컨센서스 디자인을 암호화하는 새로운 뎅기열 DNA 백신의 면역 프로필 및 반응Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] MERS, 변종, 진단, [키워드] antibody Antibody-dependent enhancement Antigen antigens clinical isolates coding sequence Consensus consensus sequence conserved COVID-19 pandemic Dengue dengue surveillance. dengue virus DENV-2 DNA DNA vaccine domain domain III EDIII domain emerging viruses envelope protein epitope Epitopes expand Genotype highlight IgG1 immune immune response immunogenic Immunoglobulin India Indo-African interferon isolate mice neutralizing antibody non-structural protein NS1 protein passive transfer protein expression response sequence Sequencing sera serotype serotype-specific staining Stand Structural analysis Surveillance T cell T cell responses transfer translation vaccination Vaccine vaccine candidate Vaccine design Viral Viral variants virulent viruses whole genome Whole genome sequencing [DOI] 10.1016/j.ymthe.2022.01.013 PMC 바로가기 [Article Type] Article