intranasal – Page 22 – Communicable Diseases Research

Potential Role of Xylitol Plus Grapefruit Seed Extract Nasal Spray Solution in COVID-19: Case Series

Otolaryngology

Published on 2020-11-032022-10-31
Journal: Cureus [Category] COVID-19,

Conjugation of Human β-Defensin 2 to Spike Protein Receptor-Binding Domain Induces Antigen-Specific Protective Immunity against Middle East Respiratory Syndrome Coronavirus Infection in Human Dipeptidyl Peptidase 4 Transgenic Mice

Article

Published on 2020-11-012022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] Activation acute respiratory symptoms Adaptive immune response addition adjuvant administration antibody Antigen can be used candidate vaccine cause conjugation defensin Dipeptidyl peptidase 4 domain dose effective Endoplasmic reticulum ENhance enhancing the immunogenicity HBD Human human β-defensin 2 immune response immunization intramuscular intranasal investigated lack lung Medical countermeasures MERS-CoV MERS-CoV infection mice Middle East mucosal IgA response peptidase provided pulmonary fibrosis required respiratory respiratory syndrome coronavirus S RBD Safe Signaling spike Spike protein Stress subunit suppressed vaccination Vaccine vaccine candidate viral infection
[DOI] 10.3390/vaccines8040635 PMC 바로가기 [Article Type] Article

Use of hydroxychloroquine and interferon alpha-2b for the prophylaxis of COVID-19

COVID-19 예방을 위한 하이드록시클로로퀸 및 인터페론 알파-2b의 사용

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses [Category] 유전자 메커니즘, 임상, 치료제,

Clinical presentations and management of COVID-19 infected children seen in a district health facility in Kambia, northern Sierra Leone

Case Series

Published on 2020-10-272022-10-28
Journal: The Pan African Medical Journal [Category] COVID-19, MERS,

[키워드] African age Asymptomatic case sery children clinical Clinical characteristics clinical presentation clinical symptom Community Complete confirmed case Confirmed COVID-19 infection Contact tracing cough Course courses COVID-19 COVID-19 pandemic Diagnosis diagnosis of COVID-19 discharge District Fever FIVE Haemoglobin Health hospital illness individual infected case infected children initial intranasal IQR Isolation Laboratory malaria males management median medications Mild nine No complication outcome oxygen Patient Platelet positive proportion reported required Sierra Leone sub-Saharan Africa Symptom symptomatic treated Treatment ventilatory support WBC West White blood cell
[DOI] 10.11604/pamj.supp.2020.37.1.26312 PMC 바로가기 [Article Type] Case Series

SARS-CoV-2 infection, disease and transmission in domestic cats

Research Article

Published on 2020-10-252022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS,

Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping

Research Article

Published on 2020-10-172022-10-29
Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS,

[키워드] 3D structure acute respiratory syndrome administration antibody Antibody binding approved drugs caused chicken clinician coronavirus COVID-19 cross-reactive enzyme epitope epitope mapping Epitopes exhibited feasibility FIVE Generation global pandemic Health immune responses immunization Immunoglobulin immunoreactivity include intranasal linear epitope Local mapping neutralizing antibody overlap physically Protein proteolytic proteolytic cleavage raised repurposing respiratory infections risk S trimer S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV S SARS-CoV-2 SARS-CoV-2 S scientist spike subsequent Therapeutic approach therapy treating SARS-CoV-2 infection Vaccine viral cell virus-cell membrane fusion
[DOI] 10.1155/2020/9465398 PMC 바로가기 [Article Type] Research Article

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

Research Article

Published on 2020-10-022022-10-30
Journal: JCI Insight [Category] COVID-19, MERS,

[키워드] ACE2 Analysis angiotensin-converting enzyme 2 animal model binding Brain infection COVID-19 described develop different dose disease evaluated expressing female groups Health Human human ACE2 human Ace2 protein human disease increases in infected with SARS-CoV-2 Infection Infectious disease Inflammatory Inflammatory cytokines International intranasal involved K18 K18-hACE2 knowledge low-dose lung Lung injury male mice Molecular pathology Mouse models murine pathogenesis of SARS-CoV-2 promoter Protein Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis survival transcript transgenic transgenic mice weight loss
[DOI] 10.1172/jci.insight.142032 PMC 바로가기 [Article Type] Research Article

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

Research Article

Published on 2020-09-252022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS,

[키워드] acute respiratory syndrome adaptation adaptive Amino acid animal model Antiviral BALB/c mice coronavirus coronavirus disease COVID-19 Critical deep dependent on develop Efficacy infections Inflammatory response interstitial pneumonia intranasal lung medical intervention mice modeling moderate mouse-adapted strain Mutation N501Y N501Y mutation neutralizing antibody pandemic Pneumonia Protective RBD Receptor binding domain Research respiratory tract response resulting SARS-CoV-2 SARS-CoV-2 mouse model SARS-CoV-2 strain Science Sequencing the receptor-binding domain the spike protein treat Vaccine vaccine candidate vaccine candidates viral pathogenesis viral spike protein viral strain virulence virus was used
[DOI] 10.1126/science.abc4730 PMC 바로가기 [Article Type] Research Article

A Fatal Case of COVID-19 in an Infant with Severe Acute Malnutrition Admitted to a Paediatric Ward in Niger

Case Report

Published on 2020-09-242022-10-31
Journal: Case Reports in Pediatrics [Category] COVID-19,

In Vitro Virucidal Effect of Intranasally Delivered Chlorpheniramine Maleate Compound Against Severe Acute Respiratory Syndrome Coronavirus 2

Allergy/Immunology

Published on 2020-09-172022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acute respiratory syndrome Against analysis of variance ANOVA Antiviral antiviral activity Antiviral effect average calculated CCID Cell culture Chlorpheniramine chlorpheniramine maleate clinical trials Compound Contact Control coronavirus coronavirus 2 COVID-19 COVID-2019 CPM determine dose Effect effective endpoint titer genome sequence GraphPad Prism hospitalized patient Hydroxychloroquine in vitro independent infected cells Infection Influenza initial intranasal intranasally Log reduction medication MERS-CoV Middle East Mild-to-moderate nasal Nasal spray novel coronavirus disease outbreak pandemic Patient placebo-controlled study Randomized reduced reduction in replicate respiratory respiratory syndrome coronavirus responsible Result Safe SARS-CoV SARS-CoV-2 similarity Standard deviation statistically significant strain tested Treatment USA-WA1/2020 Vero Viral load virucidal virus was tested
[DOI] 10.7759/cureus.10501 PMC 바로가기 [Article Type] Allergy/Immunology