COVID-19 Immunopathology and the Central Nervous System: Implication for Multiple Sclerosis and Other Autoimmune Diseases with Associated DemyelinationOpinion Published on 2020-06-042022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] administration alteration Antiphospholipid syndrome Autoimmune disease CNS consequence coronavirus disease COVID-19 COVID-19 disease Demyelination disease disease-modifying treatment Diseases Evidence Extended Frame health system immune pathway immune system increased alertness induce interval management modifications modify Multiple multiple sclerosis nervous Neurological diseases neurological manifestation neurologist Other pandemic Prognostic value reducing risk SARS-CoV-2 SARS-COV-2 infection sclerosis syndrome System systemic systemic lupus erythematosus the SARS-CoV-2 [DOI] 10.3390/brainsci10060345 PMC 바로가기 [Article Type] Opinion
Understanding Knowledge and Behaviors Related to CoViD–19 Epidemic in Italian Undergraduate Students: The EPICO StudyArticle Published on 2020-05-162022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Administered adopted Behavior behaviors carried caused Course courses COVID–19 decrease Epidemic Government IMPROVE Infection Intervention Italian Italy knowledge lockdown majority measure Measures modify Novel coronavirus physical activity quarantine questionnaire reduction Registered reported School smoking Spread student the epidemic undergraduates understanding virus [DOI] 10.3390/ijerph17103481 PMC 바로가기 [Article Type] Article
The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica포스포릴레이 BarA/SirA는 Salmonella enterica에서 비동족 조절기 RcsB를 활성화합니다.Research Article Published on 2020-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated activating addition Alter Bacteria bacterium binding site Cell cell envelope cell wall changes in condition Control detect domain environmental stress expressed Gene Expression Genes growth help Infection life logarithmic growth Luria-Bertani medium modify organism Organisms outer membrane perturbations promote Protein Proteins RcsB regulator Regulatory respond RNA Salmonella Signal transduction specificity Spectrum Stress Transcription [DOI] 10.1371/journal.pgen.1008722 PMC 바로가기 [Article Type] Research Article
Lessons Learned From Cases of COVID-19 Infection in South KoreaReport from the Field Published on 2020-05-072022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, MERS, SARS, [키워드] Chinese confirmed case contagious coronavirus disease country COVID-19 COVID-19 infection dead Diseases epidemiological data Government group hygiene involved large groups lesson Mask mass infection modify Patient Pneumonia Prevent public health sanitary glove South Korea spread of COVID-19 Support virus wearing masks [DOI] 10.1017/dmp.2020.141 PMC 바로가기 [Article Type] Report from the Field
Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2Article Published on 2020-03-232022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Analysis ancestor antigenicity appear bat Community coronavirus CoV descendant elevated emergence evolutionary strategies genomic region genomic structure Genotype Helicase human host immune less membrane modify morbidity Mutation mutations nine novel nucleocapsid ORF3a outbreak over Phylogeny RdRP Recombination recombination or reassortment Region reproductive S gene SARS-CoV SARS-CoV-2 selected spike glycoprotein survival virus whole-genome [DOI] 10.3390/pathogens9030240 PMC 바로가기 [Article Type] Article
Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies새로운 효모 단백병증 모델 및 유전자 변형 파리에서 PBP1/ATXN2 기능의 손실에 의해 칼슘 반응성 트랜스활성제(CREST) 독성이 구출됩니다Research Article Published on 2019-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Affect aggregate aggregation ALS Amyotrophic lateral sclerosis ATXN2 calcium caused chaperone CREST cytoplasmic degenerative Deletion disease Disease model Diseases downregulation Drosophila effective enhancer expressed facilitate foci form ganglion cell ganglion cells Genes inhibit Lateral Sclerosis Like Localization mammalian cells mechanism modify Mutation neurodegenerative neurons nuclear ortholog overexpressing overexpression phenotype Propagation Protein Proteins reduce reduced regulated required rescued risk factor shown Spectrum SS18L1 targets therapeutic target therapy Thioflavin toxic Toxicity transgenic yeast yeast form yeast forms [DOI] 10.1371/journal.pgen.1008308 PMC 바로가기 [Article Type] Research Article
Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine스트레스 반응 및 대사 유전자 조절은 낮은 S-아데노실메티오닌에서 변경됩니다.Research Article Published on 2018-11-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated activating Acute stress affected alcohol analyzed animal animals assays Bacterial Caenorhabditis elegan Caenorhabditis elegans choline chromatin cystic fibrosis deficiencies deficiency disease Disease progression DNA Donor elegan elegans enzyme Enzymes exacerbate expression fibrosis Gene Expression Gene regulation Genes Genetic group Heat shock heat stress histone Histones in some influence less metabolism metabolite methionine methyl groups Methylation Modification modify nucleic acid organism Organisms pathogen Phosphatidylcholine Phospholipids produced Protective provide Reactions reduced Regulation required respond response responses RNA S-adenosylmethionine SAM Stress stress conditions survival tissue injury Transcription transcriptional response transcriptional responses variety [DOI] 10.1371/journal.pgen.1007812 PMC 바로가기 [Article Type] Research Article
Exercise intervention alters HDL subclass distribution and function in obese women운동 중재는 비만 여성의 HDL 하위 분류 분포와 기능을 변경합니다.Research Published on 2018-10-102022-09-06 Journal: Lipids in Health and Disease [Category] Communicable Disease, [키워드] activating activity Adhesion Molecule aerobic African Alter Analysis Anti-inflammatory anti-inflammatory function Antioxidative assigned Blood body mass body mass index cardiovascular risk cell adhesion molecule cellular cholesterol Cholesterol efflux clinical condition controls decrease distribution endothelial exercise Exercise intervention expression HDL HDL structure HDL subclass high-density High-density lipoprotein Intervention Level modify obese obese patients obesity Platelet platelet activating factor Randomly reduce reduction in resistance exercise Result serum South subclass supplementary material Trial vascular cell adhesion venous venous blood were measured western blotting women [DOI] 10.1186/s12944-018-0879-1 PMC 바로가기 [Article Type] Research
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesCaenorhabditis elegans 단백질 FIC-1은 Heat-Shock 70 계열 단백질, 번역 연장 인자 및 히스톤을 공유적으로 수정하는 AMPylase입니다Research Article Published on 2016-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach ATP bacterial pathogen biochemical Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans connection consequence conserved core histone domain elegan elegans elongation elongation factors Endoplasmic reticulum Factor Factors family family members functional Heat shock heat shock protein heat-shock protein histone identify in vitro in vivo innate immune response Innate immunity modify novel nuclear ortholog P . aeruginosa pathogen phenotype post-translational modification Previous studies previous study Protein Proteins Pseudomonas aeruginosa sequence identity substrate susceptibility target protein target proteins three-dimensional structure translation unfolded protein response UPR [DOI] 10.1371/journal.pgen.1006023 PMC 바로가기 [Article Type] Research Article
Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis PneumoniaHIV-1 질병 진행 및 기포자폐렴에서 APOBEC3F 유전자 변이의 역할Research Article Published on 2016-03-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI acquisition Affect AIDS allele Americans antiviral activity APOBEC3 cytidine deaminase APOBEC3F APOBEC3G association cohorts collaboration cytidine cytidine deaminases Degradation degrade demonstrated disease Disease progression ENCODE epidemiological European Evidence Factor Frequency gene family Genetic genetic association Genetic variant genetic variants Genomics Haplotype hazard HIV HIV disease HIV-1 host susceptibility Human in vitro in vitro experiments in vivo intrinsic modify modulate Pathogenesis pathway performed Pneumonia progression Protein Proteins provide reduced relative resistance factors resolved role significantly lower SNP validation study variant Viral viral infectivity Viral load [DOI] 10.1371/journal.pgen.1005921 PMC 바로가기 [Article Type] Research Article