Antibody Response of Combination of BNT162b2 and CoronaVac Platforms of COVID-19 Vaccines against Omicron VariantArticle Published on 2022-01-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addition assigned Beta booster booster dose Combination CoronaVac COVID-19 COVID-19 vaccines delta variant demonstrated dose doses ENhance first dose four groups heterologous prime-boost immune response Inactivated vaccine Live virus microneutralization mRNA vaccine naïve individual Neutralizing activity neutralizing antibody of BNT162b2 omicron Omicron variant participant platform receiving reduced response SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 virus variants second dose sera significantly higher titre Vaccine Vaccines variant virus was determined was used wild-type virus [DOI] 10.3390/vaccines10020160 PMC 바로가기 [Article Type] Article
Antibody Responses after SARS-CoV-2 Vaccination in Patients with Liver Diseases간 질환 환자에서 SARS-COV-2 백신 접종 후 항체 반응Brief Report Published on 2022-01-212022-09-01 Journal: Viruses [Category] 진단, 치료기술, [키워드] Adequate advanced age age anti-SARS-CoV-2 anti-SARS-CoV-2 antibody Antibody titers Breakthrough infection cirrhosis coefficient Control controls correlated Efficacy Humoral response humoral responses IgG antibodies IgG antibody Immunosuppression Immunosuppressive treatment Liver disease liver diseases mRNA-based vaccine multivariable analysis Neutralizing activity no difference no differences Patient paucity of data post vaccination profiles reported response Safe SARS-CoV-2 SARS-CoV-2 vaccine seroconversion rates Side effect symptomatic vaccination [DOI] 10.3390/v14020207 PMC 바로가기 [Article Type] Brief Report
mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variantmRNA 부스터 면역화는 SARS-CoV-2 오미크론 변이체에 대한 강력한 중화 혈청 활성을 유도합니다Brief Communication Published on 2022-01-192022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 변종, 진단, [키워드] antibodies BNT162b2 booster Booster vaccine both groups Clinical use Cohort convalescent individual convalescent individuals COVID-19 vaccine dose elicit epitope Epitopes globe glycoprotein humoral immune response immune evasion immunization IMPROVE in both group individual Infection lack monoclonal antibodies monoclonal antibody mRNA Mutation neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity omicron Omicron variant polyclonal sera Pseudovirus neutralization assays rapid increase recipient recipients SARS-CoV-2 sera serum serum neutralizing capacity significant increase spike glycoprotein the SARS-CoV-2 Vaccines variant variant of SARS-CoV-2 Viral viral spike [DOI] 10.1038/s41591-021-01676-0 PMC 바로가기 [Article Type] Brief Communication
Antibody Responses to BNT162b2 Vaccination in Japan: Monitoring Vaccine Efficacy by Measuring IgG Antibodies against the Receptor-Binding Domain of SARS-CoV-2Research Article Published on 2022-01-192022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, [키워드] acute respiratory syndrome age analyzed antibody antibody isotype antibody production Antibody Response BNT162b2 BNT162b2 vaccine cause clinical setting Cohort coronavirus coronavirus disease correlated correlation COVID-19 detect determine dose Efficacy enzyme enzyme-linked immunosorbent Factors female Gender high correlation hypertension IgA IgG IgG level IgM immunoassay individual individuals information Japan Japanese Laboratory levels of antibodies males mass vaccination MONITOR monitoring mRNA vaccine negative correlation Neutralizing activity of BNT162b2 powerful tool predict provide RBD reported response SARS-CoV-2 SARS-CoV-2 vaccination second dose second vaccination sera Serological assay significantly significantly higher the receptor-binding domain vaccinated individual vaccination Vaccination strategy Vaccine was measured were measured [DOI] 10.1128/spectrum.01181-21 PMC 바로가기 [Article Type] Research Article
Patterns of neutralizing humoral response to SARS-CoV-2 infection among hematologic malignancy patients reveal a robust immune response in anti-cancer therapy-naive patients혈액 학적 악성 악성 환자들 사이에서 SARS-COV-2 감염에 대한 체액 반응을 중화시키는 패턴은 항암 치료-상대 환자에서 강력한 면역 반응을 나타낸다.Clinical Trial Published on 2022-01-182022-09-01 Journal: Blood Cancer Journal [Category] 임상, 진단, [키워드] analyzed anti-cancer treatment anti-SARS-CoV-2 humoral Chemotherapy COVID-19 cross-sectional cross-sectional study enhanced geometric geometric mean Haematological cancer Hematologic malignancy HM patient HM patients humoral IgG titers immune response Infection Infectious diseases lowest lymphoid malignancy Medical research natural infection neutralization titer Neutralizing Neutralizing activity Patient pattern PCR-confirmed Post-infection question raising receive receiving robust SARS-CoV-2 immunity SARS-COV-2 infection seroconversion rate seroconvert serum severe COVID-19 symptomatic symptomatic COVID-19 the patient therapy understanding Vaccination strategies Vaccination strategy Vaccine vulnerable population [DOI] 10.1038/s41408-022-00608-6 PMC 바로가기 [Article Type] Clinical Trial
Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responsesmRNA 백신 반응을 평가하기 위한 대리 SARS-CoV-2 바이러스 중화 분석의 개발 및 활용Research Article Published on 2022-01-182022-09-12 Journal: PLoS ONE [Category] 진단, [키워드] angiotensin angiotensin converting enzyme biosafety biotinylated booster Booster vaccine Complete configuration correlation COVID COVID-19 COVID-19 patient COVID-19 patients Decline declines development doses ELISA ELISAs enzyme evaluate gold gold standard help heterogeneous highlight Highlights host receptor immunoassay Infection inhibitory activity Interaction Longitudinal analyses longitudinal analysis mRNA vaccine Neutralization assay neutralization test Neutralizing activity plaque reduction neutralization Plaque reduction neutralization test post vaccination PRNT raise RBD receptor Receptor binding domain recipient Recovered COVID-19 patients response SARS-CoV-2 immunity SARS-CoV-2 spike SARS-CoV-2 viral serum Serum neutralizing antibody significant difference significant differences significantly higher Spike protein Test tested vaccinated individual vaccination Vaccine vaccine response vaccine responses viral culture was used within 6 months [DOI] 10.1371/journal.pone.0262657 PMC 바로가기 [Article Type] Research Article
Kinetics and persistence of cellular and humoral immune responses to SARS‐CoV‐2 vaccine in healthcare workers with or without prior COVID‐19이전 COVID-19 유무에 관계없이 의료 종사자의 SARS-CoV-2 백신에 대한 세포 및 체액 면역 반응의 동역학 및 지속성Original Article Published on 2022-01-182022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, 변종, 진단, [키워드] antibody antibody levels baseline BNT162b2 BNT162b2 mRNA vaccine cellular cellular immune responses circulating viral variant conducted COVID‐19 death declining decrease descending diagnosed dose form healthcare worker Healthcare workers highest Hospitalization humoral immune response humoral responses IFN IFN‐γ IgA level IgA levels IgG antibodies immune response immune response post‐infection immune response post‐vaccination immune responses Infection Kinetics longitudinal study mRNA vaccine natural infection neutralization Neutralization assay Neutralizing activity Neutralizing antibodies new infections of BNT162b2 participant persistence preserved SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 infection secretion significantly spike‐specific CD4+ T cell spike‐specific CD8+ T cell subject T‐cell the disease titre Vaccine vaccine dose Viral waning immunity [DOI] 10.1111/jcmm.17186 PMC 바로가기 [Article Type] Original Article
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift Research Published on 2022-01-112022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 amino acid substitution antigenic antigenic site bind conserved convalescent individual dose Effectiveness ENCODE epitope fraction human ACE2 immune evasion in vitro individual less magnitude monoclonal antibody MOST neutralized Neutralizing Neutralizing activity neutralizing antibody neutralizing monoclonal antibody omicron overcome pandemic plasma pseudovirus raising RBD receptor-binding motif recognize reductions in sarbecovirus SARS-CoV-2 SARS-CoV-2 variant the receptor-binding domain the spike protein Vaccine variant Wuhan-Hu-1 zoonotic [DOI] 10.1038/s41586-021-04386-2 [Article Type] Research
Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2 Research Published on 2022-01-112022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, [키워드] amplified antibody antibody resistance approved B.1.1.529 booster dose COVID-19 COVID-19 vaccine COVID-19 vaccines dominant Efficacy epitope cluster exhibited expected greater individual Intervention manifested monoclonal antibody mRNA-based vaccine neutralization Neutralizing activity omicron Patient patients SARS-CoV-2 serum spike mutation Spread subsequent tested the spike protein Therapies trajectory Transmissibility variant variant of SARS-CoV-2 [DOI] 10.1038/s41586-021-04388-0 [Article Type] Research
Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron Research Published on 2022-01-112022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] activity acute respiratory syndrome appear B.1.1.529 B.1.351 B.1.617.2 Beta binding caused convalescent coronavirus country Delta Evidence Host Immune escape individual individuals Infection investigated Mutation N-terminal domain Neutralizing activity omicron participant provided reduced retained SARS-CoV-2 SARS-CoV-2 isolate sera serum significantly South Africa spike gene Spike protein Spike proteins undetectable vaccinated individuals vaccination Vaccine variant virus-neutralizing was reduced wild type wild-type wild-type virus [DOI] 10.1038/s41586-022-04399-5 [Article Type] Research