SARS-CoV-2 spike evolutionary behaviors; simulation of N501Y mutation outcomes in terms of immunogenicity and structural characteristicSARS-CoV-2 스파이크 진화 행동; 면역원성 및 구조적 특성 측면에서 N501Y 돌연변이 결과 시뮬레이션Article Published on 2022-02-012022-09-11 Journal: Journal of cellular biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach changed characteristic coding region coding regions computation Computational biology consequence coronavirus COVID-19 enzyme facilitate focus free energy Genome host cells immunogenicity immunoinformatics increase interact Lineage molecular molecular dynamics Mutation N501Y N501Y mutation Noncoding region occur outcome Protein protein folding protein-protein interaction RBD RBD mutations Receptor-binding domain reduce Region reported SARS-CoV-2 SARS-CoV-2 spike secondary structure severe acute respiratory syndrome Coronavirus significantly South Africa spike Spike protein stability tertiary structure the receptor-binding domain the spike protein virus without affecting [DOI] 10.1002/jcb.30181 PMC 바로가기 [Article Type] Article
SARS-CoV-2 mRNA vaccine induces robust specific and cross-reactive IgG and unequal neutralizing antibodies in naive and previously infected peopleSARS-CoV-2 mRNA 백신은 순진하고 이전에 감염된 사람들에게 강력한 특이적이고 교차 반응성인 IgG 및 불평등한 중화 항체를 유도합니다.Article Published on 2022-02-012022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alpha alpha and delta variants antibody Antibody Response Complete coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlates of protection COVID-19 Critical cross-reactive cross-reactive antibodies cross-reactive antibody delta variant Endemic first dose Frequency healthy individual human endemic coronavirus IgG individual individuals induce infected individual infected individuals Infection mRNA mRNA vaccine naïve individuals neutralization Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses pandemic reference strain respiratory robust SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants seasonal coronavirus seasonal coronaviruses second dose serostatus serostatus determination Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 strength Support understanding vaccination Vaccination strategy vaccine dose Variability variability in antibody response. variants [DOI] 10.1016/j.celrep.2022.110336 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like propertiesSARS-CoV-2 스파이크 S1 소단위체는 신경염증, 소교세포 및 행동병 반응을 유도합니다: PAMP 유사 특성의 증거Article Published on 2022-02-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] activated Activation Anxiety avoidance Brain brain region brain regions CAGE CD11b CD200R1 cells characterized CNS cognitive CXCL1 cytokine signaling demonstrated Depression Direct direct viral infection Evidence evidence of examined function Gene Expression GFAp HEK293 HEK293 cells HMGB1 Hypothesis IFNγ IL-10 IL-1β IL-2 IL-6 IL1B in vitro include independent independent of induce Infection Inflammatory injected male mechanism MHCII microglia microglial modulated Neuroinflammation neurological Neuropsychiatric NLRP3 PAMP PAMPs pathogen pathogen-associated molecular Pattern recognition pattern recognition receptor Protein protein level protein levels receptor signaling reduced S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein Sickness Sickness behavior spike Spike protein structural protein structural proteins Symptom the S1 subunit the SARS-CoV-2 TLR TLR. TLR2 TLR4 TNF transgenic Treatment vehicle viral infection [DOI] 10.1016/j.bbi.2021.12.007 PMC 바로가기 [Article Type] Article
Intensity of mycophenolate mofetil treatment is associated with an impaired immune response to SARS-CoV-2 vaccination in kidney transplant recipients마이코페놀레이트 모페틸 치료의 강도는 신장 이식 수혜자의 SARS-CoV-2 백신 접종에 대한 손상된 면역 반응과 관련이 있습니다Observational Study Published on 2022-02-012022-09-12 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% CI analyzed antibodies Antibody titer clinical research/practice Concentration Control controls correlated dose dose-dependent Efficiency Factor had no IgG antibody immune response immunosuppression/immune modulation immunosuppressive immunosuppressive drug immunosuppressive regimens Infection infection and infectious agents - viral infectious agent kidney kidney transplant recipient kidney transplantation/nephrology MMF Modification multicenter multivariate regression analysis neutralization capacity Neutralizing antibodies prospective observational study recipient regimen S1 subunit SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination Seroconversion seropositive significantly lower treated Treatment vaccination Vaccine [DOI] 10.1111/ajt.16851 PMC 바로가기 [Article Type] Observational Study
Immunologic response of mRNA SARS-CoV-2 vaccination in adolescent kidney transplant recipients청소년 신장 이식 환자에서 mRNA SARS-CoV-2 백신 접종의 면역학적 반응Article Published on 2022-02-012022-09-12 Journal: Pediatric Nephrology (Berlin, Germany) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adolescent age anti-S antibody antibody Antibody Response Cellular immune response Corticosteroid COVID-19 COVID-19 infection described dose ENhance evaluated Future General population Immunologic Immunosuppressed Immunosuppression inhibitor IQR kidney transplant kidney transplant recipient lower dose mRNA mRNA vaccine non-responders participant Patient patients pediatric positive positive antibody response Protein regimen reported routine clinical care Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose solid organ transplant SOT SOT patient SOT patients Support the median the vaccine treated vaccination vaccine immunogenicity vaccine response Viremia [DOI] 10.1007/s00467-021-05256-9 PMC 바로가기 [Article Type] Article
Glycosylation and Serological Reactivity of an Expression-enhanced SARS-CoV-2 Viral Spike Mimetic발현이 강화된 SARS-CoV-2 바이러스 스파이크 모방체의 당화 및 혈청학적 반응성Research Article Published on 2022-01-302022-09-10 Journal: Journal of Molecular Biology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Abstract analysed Analysis antibody antigenic capture changes in clinical sample clinical samples COVID-19 patient COVID-19 patients detect discrepancies exhibit expression Extensive feature globe glycoprotein Glycoproteins glycosylation HexaPro IgA IgG IgM response IgM responses impacted include infected individual infected individuals Mimetic N-linked glycan N-linked glycans N-linked glycosylation observation performed Perturbation prefusion conformation proline proline substitution Protein protein structure reactivity S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 spike sera serological serological activity serological assessment serological studies serology spike stability Substitution substitutions trimeric spike Variation variations Viral viral glycoprotein viral glycoproteins virus viruses [DOI] 10.1016/j.jmb.2021.167332 PMC 바로가기 [Article Type] Research Article
Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts감염된 소아 및 밀접 접촉자의 타액 및 혈청 내 SARS-CoV-2에 대한 IgM, IgA 및 IgG의 다중 항체 분석Immunology Published on 2022-01-272022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료법, [키워드] Adults Affect anti-S IgG antibodies antibody antibody - antigen complex Antigen Barcelona Blood children Clustering analysis complementary Contact correlated correlation COVID-19 determine diagnosed diagnostic evaluate evaluated females field FIVE IgA IgG IgG antibodies IgG antibody IgM Immunity individual infected children infected individual longitudinal study Luminex assay male Non-invasive nucleocapsid Patent pediatric plasma Population positive individual Prevalence Protective Public health interventions RBD response RT-PCR Saliva SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 spike serum serum/plasma significantly higher Spain suggested summer Surveillance symptomatic individuals tested Transmission utility vaccination [DOI] 10.3389/fimmu.2022.751705 PMC 바로가기 [Article Type] Immunology
A Single Dose of an MVA Vaccine Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Protein Neutralizes Variants of Concern and Protects Mice From a Lethal SARS-CoV-2 Infection사전 융합 안정화 SARS-CoV-2 스파이크 단백질을 발현하는 MVA 백신의 단일 용량은 우려의 변종을 중화하고 치명적인 SARS-CoV-2 감염으로부터 마우스를 보호합니다Immunology Published on 2022-01-272022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, [키워드] administration animal models Antibody titers C57BL/6 caused Cell clinical trials concern COVID-19 vaccine Cytokines demonstrated dose Efficacy expressed expressing expression full-length hACE2 histopathological IgG immune responses immunized immunogenicity K18-hACE2 mice lesions lethal Lungs mice modified vaccinia virus morbidity morbidity and mortality mouse model MVA vector Neutralizing antibody titer neutralizing antibody titers parental poxvirus prefusion-stabilized S protein pro-inflammatory cytokine pro-inflammatory cytokines protective efficacy Protein reducing S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2 viral loads single dose spike T-cell immune responses transgenic vaccine candidate variants variants of concern Viral viral loads viruses wild-type [DOI] 10.3389/fimmu.2021.824728 PMC 바로가기 [Article Type] Immunology
Limited Variation between SARS-CoV-2-Infected Individuals in Domain Specificity and Relative Potency of the Antibody Response against the Spike Glycoprotein스파이크 당단백질에 대한 항체 반응의 도메인 특이성과 상대적 효능에서 SARS-CoV-2 감염 개인 간의 제한된 변이Research Article Published on 2022-01-262022-09-12 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity analyzed anti-spike antibodies anti-spike antibody antibodies antibody Antibody neutralization Antibody Response Antibody responses antiviral activity caused characterized collected composed convalescent convalescent-phase plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine defined domain domains Efficacy elicit elicited exhibited fixed form generate immunoassay immunoglobulins individual infected individual Limited MOST N-terminal domain neutralization neutralization potency neutralize Neutralizing activity Neutralizing antibodies NTD pandemic plasma samples polyclonal potency produced Protective pseudovirus quantity RBD Receptor-binding domain Region relative replication-competent SARS-CoV-2 response Sample SARS-CoV-2 SARS-CoV-2 spike serum serum and plasma Seven severe acute respiratory syndrome Coronavirus specificity spike glycoprotein Spike protein subject subjects subunit subunits tested the antibodies the antibody the antibody response the RBD the receptor-binding domain the Spike the spike protein trimer vaccinated individual Variability Variation virus while [DOI] 10.1128/spectrum.02676-21 PMC 바로가기 [Article Type] Research Article
Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects macaques from infection합성 SARS-CoV-2 S 당단백질 바이러스 유사 입자로 면역화하여 원숭이를 감염으로부터 보호Article Published on 2022-01-242022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha anti-receptor-binding domain anti-S antibodies Antibody Response Antibody titer Antibody titers approach B cells Beta boost caused CD4 classical clinical testing coated Complete coronavirus COVID-19 cynomolgus macaque cynomolgus macaques formaldehyde formaldehyde cross-linking Gamma Health Health crisis IgA titers IgG Immunity immunization Immunoglobulin Immunoglobulin G induce Infection macaque macaques Nanoparticles nasopharyngeal Neutralizing activity pandemic predominant PROTECT protection Receptor-binding domain receptor-binding domains respiratory S glycoprotein Safe SARS-CoV-2 SARS-CoV-2 S glycoprotein SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus sterilizing immunity T cell T cell responses T helper the vaccine trimer vaccine candidate vaccine strain variant Vesicle Virus-like particle virus-like particles [DOI] 10.1016/j.xcrm.2022.100528 PMC 바로가기 [Article Type] Article