Cell Type-Specific Functions of Period Genes Revealed by Novel Adipocyte and Hepatocyte Circadian Clock Models새로운 지방세포 및 간세포 일주기 시계 모델에 의해 밝혀진 기간 유전자의 세포 유형별 기능Research Article Published on 2014-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adipocytes Affect amplitude animals Behavior biochemical Bmal1 Brain Cell cell types cellular circadian clock circadian rhythms CLOCK component Cry1 Cry2 Effect evaluated expected Families feasible fibroblasts function Gene Expression Genes Genetic genomic hepatocyte hepatocytes hypothalamus Impact implication Interaction kinetic knockdown knockout mice lentivirus library Local Luminescence mechanism metabolism microplate reader Model molecular negative feedback negative feedback mechanism neurons novel nuclei Per1 Per2 PER3 Period phenotype Physiology Previous studies regulated reporter reveal Revealed RNA RNA interference small molecule Small molecules tissue specific transcriptional [DOI] 10.1371/journal.pgen.1004244 PMC 바로가기 [Article Type] Research Article
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다Research Article Published on 2013-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated After allele Analysis approved drug Arthritis association Author B cells B lymphocyte B lymphocytes Biology can be used CD19+ CD40 CD40 ligand CD40 signaling Cell cell line chemical compounds clinical care coding Combination complex Compound consequence controls correlation counter deep sequencing develop disease drug Drug discovery drugs effort eQTL ExoN exonic explain expression finding Follow-up gain-of-function Genetic genetic findings Genome-wide association studies Genome-wide association study genotyping guide GWAS healthy control homozygous Human Human genetics identify implicated increase individuals Infection Inflammation inhibit inhibitor loci locus lymphocyte Lymphocytes mononuclear cell mononuclear cells mouse NF-kB NF-κB NF-κB signaling non-risk allele observé p65 pathway Patient Peripheral blood Peripheral blood mononuclear cells Phosphorylation Protein Quantitative RA RELA reporter retroviral Rheumatoid rheumatoid arthritis risk risk allele Screen second Sequencing seropositive Signaling single SNP small molecule Small molecules small-molecule screen subject subunit therapy trait traits transcription factor treat variant while [DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article
A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease게놈 규모의 RNA-간섭 스크린은 헌팅턴병의 병리학적 특징으로 RRAS 신호를 식별합니다Research Article Published on 2012-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition Amino acid amino-terminus Analysis Author cascade caused Cell cellular cellular processe cellular processes component disease disorder Drosophila dysfunction effective ENCODE enzyme excitotoxicity farnesyltransferase FNTA found functional Glutamate Glutamine huntingtin Huntington's disease identify implicated in addition to increase in inhibitor Interaction Intervention involved Localization loss-of-function mammalian mechanism mechanisms mitochondrial mitochondrial dysfunction motor dysfunction mouse model mutant Mutation observé occur pathogenic pathway Pathways pharmacological PIN1 PLK1 Protein proteolysis RAF1 reduce reduced reducing repeated RNA interference RRAS Screen Signaling signaling pathway small molecule solubility suppress suppressed suppressor Therapeutic benefit These data Toxicity was performed [DOI] 10.1371/journal.pgen.1003042 PMC 바로가기 [Article Type] Research Article
Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection작은 분자에 의한 숙주 면역 방어의 자극은 세균 감염으로부터 C. elegans를 보호합니다Research Article Published on 2012-06-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Analysis antibiotic Antibiotics ATF-7 Author Bacterial Bacterial infection Bacterial infections bacterial pathogen Bacterial pathogens Caenorhabditis elegan Caenorhabditis elegans cellular processe cellular processes Compound conserved effector molecule Efficacy elegan expression Gene Genes growth Host immune response host immunity identify immune immune regulators immunostimulatory Infection Interaction low molecular weight mechanism mechanism of action mode molecule molecules mutants nematode offer Pathogens pathway promote PROTECT Pseudomonas aeruginosa required small molecule Small molecules stimulate Stimulation tested therapy These data Transcription transcription factor Transcriptome Treatment variety [DOI] 10.1371/journal.pgen.1002733 PMC 바로가기 [Article Type] Research Article
Yeast Based Small Molecule Screen for Inhibitors of SARS-CoVResearch Article Published on 2011-12-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activities activity Alter bypasse Cell culture cells cellular connection conserved Course demonstrated deubiquitinase Diversity expressed functional growth human coronaviruses induce induction Influenza virus inhibit inhibited inhibiting the function inhibitor inhibitory compounds investigated likelihood mammalian cells mechanism modify molecule Mortality NIH outbreak Papain-like protease phenotype PLP precursor protease Protease activity Replication reservoir Respiratory Coronavirus resulting S. cerevisiae SARS-CoV Screen severe shown small molecule suppressor toxic effect virus replication yeast [DOI] 10.1371/journal.pone.0028479 PMC 바로가기 [Article Type] Research Article