The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease인간 표현형 온톨로지: 일반 및 희귀 질병의 의미적 통합Article Published on 2015-07-022022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] alleles annotation annotations can be used common common disease common diseases comparable resource concept-recognition procedure diagnostics disease Disease model disease models FIVE frequencies Frequency genomic location HPO annotations Human human disease iterative procedure Mendelian disease Mendelian diseases next-generation sequence-variation data phenotype-driven analysis phenotypic annotation phenotypic overlap Precision precision and recall PubMed abstract rare disease community recall Research risk translational Translational research Unification [DOI] 10.1016/j.ajhg.2015.05.020 PMC 바로가기 [Article Type] Article
How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes: a review세포 사멸 β 세포가 내성 또는 자가 면역 당뇨병에 대한 면역 반응을 지시하는 방법: 리뷰Original Paper Published on 2015-01-222022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] β-Cells Activation antigen presenting cell antigen presenting cells APCS Apoptosis apoptotic cell clearance apoptotic cells apoptotic β-cell autoantigen Autoantigens Autoimmune autoimmune attack autoimmune diabetes Autoimmune disease Autoimmune diseases Autoimmunity Cell contribute contributing to dendritic cells diabetes Effect Efferocytosis endogenous insulin secretion immune response immune tolerance immunological tolerance immunotherapies Immunotherapy increase in induce Inflammation insulin insulin-producing β-cell insulin-producing β-cells long-term tolerance maintenance maturation mechanism medical health challenge metabolic disease pancreatic islet pancreatic islets pancreatic islets of Langerhans Patient physiological mechanism Research self T1D target cell target cells therapy Tolerance tolerance to self translational Treatment Type 1 diabete Type 1 diabetes β-cell β-cells [DOI] 10.1007/s10495-015-1090-8 PMC 바로가기 [Article Type] Original Paper
Integrative “Omics”-Approach Discovers Dynamic and Regulatory Features of Bacterial Stress Responses통합 "Omics" 접근 방식으로 세균 스트레스 반응의 동적 및 조절 기능 발견Research Article Published on 2013-06-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (transcriptome adaptation adaptive mechanism adaptive mechanisms addition alternative approach assigned Author Bacteria cellular stress responses change choice complex conditions determine different dynamic Effect elevated temperature event events example exhibited expression expression level expression pattern expressome Factor Factors feature found fraction Frequency Gene Genes Genome help in addition to include initiated integration maintain mass spectrometry Microarrays mRNA mRNA level mRNA levels mRNAs Occurrence open reading frames operon organism oxygen phototrophic polar polysome Population post-transcriptional level Protein Proteins proteome provided quantification quorum regulated Regulation Regulatory reported required response RNA-Seq RpoE singlet oxygen Stress stress condition stress conditions stress response stress responses survival transcriptional activation transcriptional level transcriptional regulator transcriptional regulators Transcriptome translation translational was used [DOI] 10.1371/journal.pgen.1003576 PMC 바로가기 [Article Type] Research Article
Regulation of Programmed Ribosomal Frameshifting by Co-Translational Refolding RNA HairpinsResearch Article Published on 2013-04-292022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 293T cells base pair base-pair determined disrupt downstream Efficiency example functional Hairpin in vitro mechanism provide Regulation regulatory element required reveal RNA RNA structure SARS Coronavirus SARS-CoV sequence variation shown stability stimulated translational upstream yeast [DOI] 10.1371/journal.pone.0062283 PMC 바로가기 [Article Type] Research Article
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6 , a Gene Identified through Mining the DPH1 – DPH5 Interaction Network효모에서 디프타마이드 생합성의 아미드화 단계에는 DPH1 - DPH5 상호작용 네트워크 마이닝을 통해 확인된 유전자인 DPH6이 필요합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy adenine adenine nucleotide ADP Affect agent amidase Amino acid approach association ATP Author bind Biosynthesis biosynthetic biosynthetic pathway candidate candidate gene Cell cell growth characterized check Complete completion component components Corynebacterium diphtheriae defined Diphthamide dissociation domain DPH1 Dph5 Dph6 Dph7 eEF2 elongation factor embryogenesis enzyme evade expected failure Final form found generate Genes Genetic genetic interaction genomic growth histidine Identified identify inactivation indicated inhibitor inhibitors initial Interaction involved Like maintain mass spectrometry mice molecular mutant name network nucleotide observation pathogen pathway produced promote Protein protein synthesis Proteins Regulatory required residue response Saccharomyces cerevisiae step target trait translation translational upregulated [DOI] 10.1371/journal.pgen.1003334 PMC 바로가기 [Article Type] Research Article
Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host CellsReview Published on 2012-05-022022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Control defined dsRNA molecules gastroenteritis host cell inducer induction inhibit interfere less natural post-transcriptional regulation PRRSV Regulation reproductive respiratory syndrome TGEV translational translational control Type type I interferon virus [DOI] 10.3390/v4050725 PMC 바로가기 [Article Type] Review
Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus VirulenceResearch Article Published on 2011-06-092022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accelerated accessory gene acquisition Activation Analysis Antiviral antiviral response Apoptosis assay association Author benefit binding caspase catalytic caused Cell cellular RNA clinical disease compared conserved coronavirus CoV cultures Cytopathic effect Defense Degradation Deleterious demonstrated eIF2α ENCODE eukaryotic translation evade Evolution expression Genome growth Host host antiviral response host cell hydrophobic immune response indicated Infected infected cells Infection Innate inoculation Interaction led to mechanism modify modulation molecular mechanism motif mutant mutant virus Newborn observation parental pathology Pathways persistence Phosphorylation promoted Protein protein phosphatase 1 provided pull-down reducing required RNA degradation RNA viruses RNase selective sequence subunit suggested survival TGEV tissue translational transmissible gastroenteritis virus Viral RNA virulence virus virus infection [DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article