Community demand for comprehensive primary health care from malaria volunteers in South-East Myanmar: a qualitative study미얀마 동남부 말라리아 자원봉사자들로부터의 포괄적인 1차 건강 관리에 대한 지역 사회의 요구: 질적 연구Research Published on 2021-01-062024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] Community-delivered model Malaria elimination Myanmar Primary Health Care Volunteer [DOI] 10.1186/s12936-020-03555-4 PMC 바로가기 [Article Type] Research
Residence, Clinical Features, and Genetic Risk Factors Associated with Symptoms of COVID-19 in a Cohort of Older People in Madrid마드리드의 노인 집단에서 COVID-19의 증상과 관련된 거주, 임상 특징 및 유전적 위험 요인Observational Study Published on 2021-01-012022-09-11 Journal: Gerontology [Category] 변종, 임상, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 affected alcohol allele ApoE APOE gene association clinical clinical condition Clinical features Clinical severity coffee cognitive cognitive deterioration Cognitive impairment Cohort collected Comorbidities coronavirus Coronavirus infection COVID-19 Deterioration died disease severity Diseases exploratory study Factor Fatality rate frailty genetic polymorphisms incidence indicate Madrid males Measures Mortality mortality rate neurodegenerative Nursing nursing home Older older people older population overall mortality pandemic potential risk reported symptom residence respiratory risk factor Risk factors severe acute respiratory syndrome Coronavirus severity significantly smoking Spain symptomatic symptomatic COVID-19 symptoms of COVID-19 Systolic blood pressure telephone survey Vallecas Project. variant Volunteer [DOI] 10.1159/000513182 PMC 바로가기 [Article Type] Observational Study
Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgGResearch Published on 2021-01-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome analyzed antibody Antibody Response B cells blood donor cellular immunity Contact convalescent convalescent patient convalescent plasma coronavirus coronavirus disease COVID-19 detect Donor ELISA ELISPOT Frequency Germany IgG immune response Immunity infected patient Infection interferon-γ investigated negative controls onset of symptoms participant PCR-confirmed PCR-confirmed infection PCR-positive positive control respiratory infections SARS SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection Seronegativity Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 study participant T cell T cells T-cell immunity the S1 protein undetectable viruses Volunteer without symptom zoonoses [DOI] 10.3201/eid2701.203772 PMC 바로가기 [Article Type] Research
Evaluating the Onset, Severity, and Recovery of Changes to Smell and Taste Associated With COVID-19 Infection in a Singaporean Population (the COVOSMIA-19 Trial): Protocol for a Prospective Case-Control StudyProtocol Published on 2020-12-312022-10-29 Journal: JMIR Research Protocols [Category] COVID-19, [키워드] Ageusia Anosmia approach approved asymptomatic individual board change changes in chemosensory clinically Cluster Complete Council COVID-19 COVID-19 infection COVID-19 pandemic diagnosed Diagnosis dysfunction Evaluating Frequency group Gustatory dysfunction help Identifier Infection infections Infectious disease knowledge Longitudinal data Loss of Smell marker monitoring objective olfactory dysfunction Onset participant patients with COVID-19 PCR swab polymerase chain Population population-based cohort Prospective protocol provide questionnaire receive recovery recruited reduce Registration report respiratory tract Result review SARS-CoV-2 self-isolate sensitivity severity Singapore Smell Specific submitted sudden suggested Symptom Symptoms Taste taste change virus Volunteer with COVID-19 [DOI] 10.2196/24797 PMC 바로가기 [Article Type] Protocol
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 VaccineClinical Trial Published on 2020-12-302022-10-04 Journal: The New England Journal of Medicine [Category] MERS, SARS, 임상, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome adverse event age Analysis Aside assigned authority baseline cause Complication complications conducted coronavirus coronavirus disease development Efficacy ENCODE enrolled Evidence first dose full-length spike protein high risk incidence infected with SARS-CoV-2 injection Injections Intramuscular injection Local mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine observer-blinded occurred Older participant Participants Person Phase 3 Placebo placebo-controlled trial prefusion Prevent primary end point PROTECT Randomized Randomly reactogenicity receive Result Safety SARS-CoV-2 SARS-COV-2 infection Secondary analyses severe disease systemic reactions the placebo group The United States Trial two groups vaccination Vaccine virus Volunteer [DOI] 10.1056/NEJMoa2035389 PMC 바로가기 [Article Type] Clinical Trial
Evaluation of Two Chemiluminescent and Three ELISA Immunoassays for the Detection of SARS-CoV-2 IgG Antibodies: Implications for Disease Diagnosis and Patients’ ManagementSARS-CoV-2 IgG 항체 검출을 위한 2가지 화학발광 및 3가지 ELISA 면역분석법 평가: 질병 진단 및 환자 관리에 미치는 영향Comparative Study Published on 2020-12-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody approach Asymptomatic asymptomatic patient best chemiluminescent Chemiluminescent assay chemiluminescent immunoassay collected commercial immunoassay COVID-19 COVID-19 patient COVID-19 patients demonstrated detection disease Elecsy ELISA ELISA assay ELISA assays estimation evaluate FIVE Follow-up General population Greece IgG IgG antibodies IgG antibody immunoassay immunoassays individual infected individuals N protein number of infected outbreak Prevalence S protein SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 N protein screening method screening methods sensitivity sera Seroprevalence serum significantly higher specificity specimen Symptom symptom onset the SARS-CoV-2 Volunteer [DOI] 10.3389/fimmu.2020.609242 PMC 바로가기 [Article Type] Comparative Study
SARS-CoV-2 Seroprevalence Survey in People Involved in Different Essential Activities during the General Lock-Down Phase in the Province of Prato (Tuscany, Italy)Article Published on 2020-12-192022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] 95%CI activities activity antibody assigned authority circulation Community COVID-19 Essential essential activities evaluate finding groups Health care health care workers healthcare worker Healthcare workers help higher odd In-hospital incidence involved Italy lock-down period participant performed phase protection risk SARS-CoV-2 SARS-CoV-2 antibody serological test Seroprevalence Serosurvey Support survey tested the SARS-CoV-2 Transmission Transmission dynamics Tuscany Volunteer [DOI] 10.3390/vaccines8040778 PMC 바로가기 [Article Type] Article
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses Research Published on 2020-12-172022-10-05 Journal: Nature Medicine [Category] SARS, 유전자 메커니즘, 임상, [키워드] Activation acute respiratory syndrome animal Anti-spike antibody Antibody Response approach AZD1222 boost booster dose Booster vaccine cell activation cellular ChAdOx1 ChAdOx1 nCoV-19 clinical trials complement coronavirus coronavirus vaccine dose doses evaluated exploratory facilitate function functional antibody responses healthy homologous humoral immunogenicity data induce Infection Interim report magnitude multifunctional natural killer neutralizing antibody neutralizing antibody titers Open-label outcome phagocytosis phase Phase 3 Prevent preventing infection priming Randomized controlled trial receive reported Safe SARS-CoV-2 vaccine serology subgroup Support T cell response the vaccine Trial vaccination Vaccine viral spike protein Viral vector Volunteer [DOI] 10.1038/s41591-020-01179-4 [Article Type] Research
Evidence and implications of pre‐existing humoral cross‐reactive immunity to SARS‐CoV‐2SARS-CoV-2에 대한 기존 체액 교차 반응성 면역의 증거 및 의미Original Research Published on 2020-12-152022-09-10 Journal: Immunity, Inflammation and Disease [Category] MERS, SARS, 진단, 치료법, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antigen approach approaches building clinical trial collected coronavirus coronavirus disease Coronavirus disease 2019 Critical Elecsy healthcare healthy humoral Immunity Immunoglobulin immunoglobulins implication investigated knowledge nucleocapsid pandemic reactive reactivity respiratory respond Result SARS‐CoV‐2 sera serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subject tested Vaccine Volunteer [DOI] 10.1002/iid3.367 PMC 바로가기 [Article Type] Original Research
Predictive value of cytokine/chemokine responses for the disease severity and management in children and adult cases with COVID‐19Research Article Published on 2020-12-012022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, [키워드] acute phase Adults analyzed Biomarker candidate chemokine chemokines children Clinical data Combination coronavirus coronavirus disease COVID‐19 Critically ill Critically ill patient cytokine disease course disease severity fluorescent healthy healthy controls healthy volunteer immunoassay independent inflammatory protein Macrophage management mild patient moderate Pathogenesis pathogenicity pathophysiological mechanism patient cohort pediatric pediatrics Predictive value Prognosis Protein Research response Serum level serum sample severe disease course severity significantly higher significantly lower the disease Treatment Variation Volunteer were measured [DOI] 10.1002/jmv.26683 PMC 바로가기 [Article Type] Research Article