Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trialDNA 또는 NYVAC 벡터(HVTN 096)가 있는 외피 단백질을 포함하는 다가 HIV 백신의 안전성 및 면역원성: 1b상, 이중 맹검, 위약 대조 시험Article Published on 2019-10-072022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] active treatment Administered administration adverse event allergy antibodies antibody Antibody Response Antibody responses antibody-dependent cell-mediated cytotoxicity approach assigned binding binding antibody boost Cell-mediated cytotoxicity Combination component computer-generated Coverage cranial cytotoxicity died DNA dose doses double-blind early administration effective Efficacy enrolled envelope protein epitope finding followed by foundation funding glycoprotein gp120 healthy healthy volunteer healthy volunteers HIV infection HIV vaccine IgG IgG response IgG responses immunogenicity individual Infection Infectious diseases injection Lymphadenopathy marker measure Melinda Gate Melinda Gates motor vehicle Neutralising Antibodies outcome participant Participants Placebo placebo group placebo-controlled placebo-controlled trial Primary outcomes priming product Protein purified random Randomly reactogenicity regimen Registered responses risk Safety screened Serious Adverse Event Serious Adverse Events Switzerland the placebo group the vaccine trauma Treatment treatment group treatment groups Trial trials vaccination vaccination schedule Vaccinations Vaccine vector Volunteer [DOI] 10.1016/S2352-3018(19)30262-0 PMC 바로가기 [Article Type] Article
Mucosal Immune Response to Feline Enteric Coronavirus InfectionArticle Published on 2019-09-272022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] abnormality biopsy caused collected Colon Control convalescent coronavirus enteric expression fatal disease fecal Fecal sample feline enteric coronavirus Feline infectious peritonitis groups histologic humoral IFNγ IgG Infection inflammatory state investigated lymphocyte subpopulation mucosa mucosal mucosal IgA response mucosal immune mucosal immunity mutant virus organ pathogenic Perturbation phenotype proliferation response Result Significant suggested T cell three groups virus virus clearance [DOI] 10.3390/v11100906 PMC 바로가기 [Article Type] Article
Establishment of competitive binding assay to detect and differentiate hepatitis E virus infectionArticle Published on 2019-07-012023-06-12 Journal: Annals of hepatology [Category] E형 간염, [키워드] Genotype Genotype-specific HEV IgG monoclonal antibody [DOI] 10.1016/j.aohep.2019.01.009
Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine developmentETEC 및 Shigella 감염에서 전신 및 점막 면역 반응에서 항원 특이적 T 세포와 B 세포의 역할, 그리고 백신 개발에서 보호의 상관관계로서의 잠재력Article Published on 2019-06-202024-07-30 Journal: Vaccine [Category] 세균성이질, [키워드] B cells correlates of protection (CoP) Enterotoxigenic Escherichia coli (ETEC) IgA IgG Immunocorrelate mucosal antibodies Shigella T cells [DOI] 10.1016/j.vaccine.2019.03.040 PMC 바로가기 [Article Type] Article
Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling PigletsImmunology Published on 2019-04-242022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] acute diarrhea Affect affected antibody antibody secreting cell ASC B cells cause change circulating Control correlated Course Critical Cytokines determine during pregnancy epidemic diarrhea example gestation gut-mammary-secretory IgA axis IgA IgG immature immune system immune parameter immune protection immune response Immunity Impact implication Infection influence inoculated intestinal lactogenic Lactogenic immunity lymphocyte Maternal medium mucosal naïve Neonatal Neonate Neutralizing PEDV positively correlated Pregnancy pregnant protection required response resulting serum significantly significantly higher Stage stimulate stimulated subsequent Suckling survival survival rate swine three group Vaccines viral infections virulence virus [DOI] 10.3389/fimmu.2019.00727 PMC 바로가기 [Article Type] Immunology
Fully galactosyl-fucosyl-bisected IgG1 reduces anti-HBV efficacy and liver histological improvementArticle Published on 2019-03-012023-06-18 Journal: Antiviral Research [Category] B형 간염, [키워드] glycosylation hepatitis B IgG Liver fibrosis TGF-β1 [DOI] 10.1016/j.antiviral.2018.12.021
Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn pigletsResearch Articles Published on 2019-02-262022-10-28 Journal: Bioscience Reports [Category] Coronavirus, MERS, [키워드] administration antibody Antigen B. subtilis Bacillus subtilis candidate vaccine cause CD3 CD4 cells COE Contact contagious demonstrated develop disease effective epidemic diarrhea evaluated expressing IgA IgG immune immune response immunization Immunoglobulin immunoglobulin A Infection Local lymphocyte mucosal mucosal immune mucosal immunity Newborn oral administration Oral vaccine PEDV Peyer’s patche Piglets Porcine epidemic diarrhea virus prevented recombinant Bacillus subtilis responses secreting serum SIgA significantly significantly increased Spread systemic immune response T cells up-regulated Vaccine Vaccines virus [DOI] 10.1042/BSR20182028 PMC 바로가기 [Article Type] Research Articles
Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infectionResearch Article Published on 2019-02-212022-11-01 Journal: JCI Insight [Category] Coronavirus, SARS, [키워드] abrogated absence accumulated acute lung injury acute respiratory syndrome alveolar macrophage anti-spike antibody Antibody Response blockade cause Characteristics Chinese coronavirus CoV Cytokines Deceased demonstrated died driving Effects faster FcγR functional H7N9 hypercytokinemia IgG IL-8 immunoglobulins Infectious disease Inflammation Lung injury Lungs macaque macaques Macrophage response macrophages MCP1 mechanism MERS-CoV middle neutralizing antibody responses Patient patients proinflammatory promoted Pulmonology recruitment reduced response responsible SARS patient SARS-CoV SARS-CoV infection sera specimens syndrome Treatment viral clearance viruses [DOI] 10.1172/jci.insight.123158 PMC 바로가기 [Article Type] Research Article
Comparative Serological Study for the Prevalence of Anti-MERS Coronavirus Antibodies in High- and Low-Risk Groups in QatarResearch Article Published on 2019-02-182022-10-29 Journal: Journal of Immunology Research [Category] Coronavirus, [키워드] 229E Active surveillance antibody Asymptomatic baseline circulating close contact collected Comparative Contact coronavirus cross-reactivity determine epidemiological evaluate exhibited false-positive result FIVE General population group healthy blood donor HKU1 human coronavirus IgG IgM individual initial screening MERS-CoV MERS-CoV infection Middle East Mild neutralization NL63 OC43 PCR-confirmed patient positive Prevalence Randomly reactive reactivity reported respiratory syndrome coronavirus Sample screened selected Serological assay serological assays [DOI] 10.1155/2019/1386740 PMC 바로가기 [Article Type] Research Article
Development and Evaluation of a Multiplexed Immunoassay for Simultaneous Detection of Serum IgG Antibodies to Six Human CoronavirusesArticle Published on 2019-02-042022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] 229E addition antibody detect detection determine develop development feasible HCoV HCoVs high mortality HKU1 Human human coronavirus human sera IgG illnesses immunoassay Immunoglobulin MERS-CoV microsphere Mild mild illness moderate Multiplex assay NL63 nucleocapsid protein OC43 positive R 2 reactivity reproducibility SARS-CoV Screening sensitivity serologic assay severe respiratory disease Simultaneous specificity Surveillance [DOI] 10.1038/s41598-018-37747-5 PMC 바로가기 [Article Type] Article