A novel coronavirus capable of lethal human infections: an emerging pictureReview Published on 2013-02-282022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] acute respiratory illness Analysis caused Cluster Coronavirus (CoV) died event Evidence humans index case individual laboratory-confirmed Middle East new virus Novel coronavirus outbreak Patient provided renal renal failure reported SARS-coronavirus SARS-CoV Saudi Arabia severe respiratory infection spread to Travel virus [DOI] 10.1186/1743-422X-10-66 PMC 바로가기 [Article Type] Review
Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229EArticle Published on 2012-12-122022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] 229E acute respiratory disease alpaca anthroponosis appear characterization coronavirus demonstrated FIVE Frame Genome genomic sequencing HCoV-229E Human human coronavirus humans identification identity isolate molecular evolution MOST novel Novel coronavirus Nucleocapsid gene nucleotide occurred respiratory reverse zoonosis spike gene sequence UTR virus virus transmission zoonosis [DOI] 10.3390/v4123689 PMC 바로가기 [Article Type] Article
The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus PathogenesisReview Published on 2012-11-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Accessory accessory protein accessory proteins acute respiratory syndrome affected caused cellular China coronavirus country Effect eight ENCODE expression functional Genome homologous homologues human-to-human transmission infected individual infected individuals Infection Isolation knowledge membrane mortality rate Novel coronavirus nucleocapsid Open reading frame open reading frames ORFs predicted Protein Proteins reported Research respiratory Respiratory disease resulting role SARS-coronavirus SARS-CoV severe Spread subsequent unique virus [DOI] 10.3390/v4112902 PMC 바로가기 [Article Type] Review
Residue analysis of a CTL epitope of SARS-CoV spike protein by IFN-gamma production and bioinformatics predictionResearch Article Published on 2012-09-102022-10-28 Journal: BMC Immunology [Category] Coronavirus, Fulltext, MERS, [키워드] acute respiratory syndrome Alanine Analysis ANN antigenic epitopes ARB binding bioinformatics caused cells CTL CTL epitope demonstrated DNA electrostatic ELISA epitope exaggerate FACS functional hydrophobic IFN-gamma immunized mice induce Infectious disease Interaction lysine mutant mutated Novel coronavirus peptide peptides predicted replaced reported residue Result S protein SARS CoV SARS-CoV SARS-CoV S SARS-CoV spike protein severe Spike protein splenocyte steric T cell epitope TCR the binding affinity the mean was used [DOI] 10.1186/1471-2172-13-50 PMC 바로가기 [Article Type] Research Article
Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 ComplexResearch Article Published on 2011-05-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 activating Activation antiviral drug assay association atomic resolution Author bind binding binding pocket CAP chromatin complex coronavirus crystal crystal structures disease enzyme etiological agent exhibit functional Genome Giant host cell identify inhibitor Innate immunity involved mechanism metabolism methyltransferase mRNA mutant non-structural protein Novel coronavirus nucleic acid performed Protein provide regulated Regulation replicate residue respiratory resulting RNA S-adenosylmethionine SAM severe Signal transduction stability Structure translation viruses [DOI] 10.1371/journal.ppat.1002059 PMC 바로가기 [Article Type] Research Article
Prevalence and Phylogeny of Coronaviruses in Wild Birds from the Bering Strait Area (Beringia)Research Article Published on 2010-10-292022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis Area Bering Strait Beringia Bird bronchitis cause collected costly CoV CoV infection CoVs detected Epidemiology examined Frequency Genetic Health host range Human IBV investigated Mild Novel coronavirus pathogenic performed phylogenetic analyses related reservoir respiratory viral disease RT-PCR SARS-coronavirus severe disease Spread statistical virus widespread [DOI] 10.1371/journal.pone.0013640 PMC 바로가기 [Article Type] Research Article
Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected MiceResearch Article Published on 2009-10-232022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activated Activation Adaptive immune response allergic alveolar macrophage animal model Anti-viral Antigen Author BALB/c mice caused characterized correlated CoV dendritic cell dendritic cells deplete develop DLN draining lymph node Epidemic feature Human human disease human population humans immune response individual inefficient Infected Infection inhibitory inhibitory effect initial Liposome lung lymphopenia MA15 Macrophage mice morbidity and mortality mouse-adapted SARS-CoV Novel coronavirus occurred Patient Poor Prevent prolonged virus persistence PROTECT respiratory Respiratory disease response severe severe disease severe respiratory disease T cell response T cells Therapies TLR3 Toll-like receptor transfer treated virus virus clearance virus excretion virus-specific T cell [DOI] 10.1371/journal.ppat.1000636 PMC 바로가기 [Article Type] Research Article
Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, ItalyResearch Article Published on 2007-02-202022-11-01 Journal: Journal of medical virology [Category] Coronavirus, Fulltext, MERS, [키워드] Acute respiratory infection adopted amplified fragment approach assay Asthma Bronchiolitis bronchitis bronchopneumonia children circulation Co‐infection Department described detected detection Diagnosis enrolled Hospitalized Inc infected children Infection influenza type A involved Italy métapneumovirus molecular NL63 Novel coronavirus parainfluenza virus pathogen Patient Pneumonia positive result respiratory pathogen respiratory syncytial virus respiratory tract infection respiratory virus reverse transcription rhinovirus Rome RSV RT‐PCR sequenced the patient to define viral pathogen virus [DOI] 10.1002/jmv.20832 PMC 바로가기 [Article Type] Research Article
Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)Research Article Published on 2005-09-212022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome approach Asia biological systems Blood caused change changes in Clinical severity Clustering Control controls coronavirus correlated disease distress Epidemic expression profile Gene Gene Expression Genes Host human disease immunopathological damage Innate immunity International involved mortality rate Novel coronavirus pathophysiology Patient Peripheral blood Pulmonary infection recovering patient regulated reported Result SARS patient SARS patients SARS-CoV several gene severe severity significantly Spread upregulated while World Health Organization [DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article
Molecular mechanisms of severe acute respiratory syndrome (SARS)Review Published on 2005-01-202022-10-28 Journal: Respiratory Research [Category] Coronavirus, [키워드] acute respiratory syndrome approach caused contribute coronavirus Deleterious Effect effort Epidemics Features Genome Health immune immune system indirect effect infections Infectious disease Interaction Laboratory mechanism molecular mechanisms morbidity and mortality mutability Novel coronavirus Occurrence offer Open reading frame outbreak Pathogenesis Prevent pulmonary pathological Region required Research Respiratory disease SARS SARS-CoV severe Severe acute respiratory syndrome target cell the disease therapy vaccination Vaccine viral genome virulence virus widespread [DOI] 10.1186/1465-9921-6-8 PMC 바로가기 [Article Type] Review