Current hurdles to the translation of nanomedicines from bench to the clinicReview Article Published on 2021-07-232022-11-01 Journal: Drug delivery and translational research [Category] COVID-19, [키워드] Abstract accelerate aligned attribute characterization Critical current diagnostics early stage feature Guidance highlight include manufacturing nanomedicine Nanomedicine translation nanomedicines parameters pathway physical regenerative Regulatory regulatory agency Regulatory framework Research scale-up significantly translation [DOI] 10.1007/s13346-021-01024-2 PMC 바로가기 [Article Type] Review Article
Automated machine learning optimizes and accelerates predictive modeling from COVID-19 high throughput datasets자동 기계 학습은 CovID-19 고역 처리량 데이터 세트의 예측 모델링을 최적화하고 가속화합니다.Article Published on 2021-07-232022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, [키워드] accelerate acute respiratory illness Analysis AUC Characteristics contribute COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients dataset datasets diagnostic disease effective eight feature Healthcare systems individuals Infectious diseases Innate interferon gamma machine learning management metabolomic mRNA Multiple nine Pathway analysis Pathways performed Predictive predictors prognostic proteomic public health reduced remained respiratory selected Signaling signature System therapeutic transcriptomic Viral [DOI] 10.1038/s41598-021-94501-0 PMC 바로가기 [Article Type] Article
The Influence of Virus Infection on Microglia and Accelerated Brain AgingReview Published on 2021-07-202022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] accelerate accelerated Affect aging Brain brain aging Central nervous system contribute deficiency disease Evidence flavivirus functions Health herpes viruses HIV human herpes virus immune Immune cell induce Inflammatory influence Influenza interfere microglia Neuroinflammation neurotropic neurotropic virus physiological remodeling processes SARS-CoV-2 viral infection virus [DOI] 10.3390/cells10071836 PMC 바로가기 [Article Type] Review
Plitidepsin: Mechanisms and Clinical Profile of a Promising Antiviral Agent against COVID-19Review Published on 2021-07-162022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] accelerate acting administration affected agent anti-SARS-CoV-2 anticipated Antiviral Antiviral agents Antiviral effect antiviral property aplidin B.1.1.7 variant clinical Clinical data clinical evidence Combination COVID-19 current database demonstrated Dexamethasone effective Efficacy Ex vivo hospital hospitalized COVID-19 patients hospitalized patients Host inhibiting interactions intravenous isoform knowledge lack lineages mechanism multicentre Multiple myeloma Patient Plitidepsin Population profile regimen Remdesivir safety profile SARS-CoV-2 Standard of care standard treatment suggested translation Treatment Trial viral load reduction Viral proteins [DOI] 10.3390/jpm11070668 PMC 바로가기 [Article Type] Review
COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severityResearch Article Published on 2021-07-142022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] accelerate acute infection Analysis Antibiotic resistance bioinformatics collected Community coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 research Data analysis determine Epidemiology expected facilitate feature Genetic geographical location Health implication IMPROVE include Infection Interpretation management metatranscriptomic microbial Organisms Outbreaks pathogen Patient patients with COVID-19 platform provide respiratory tract respond risk factor SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain sequenced severity strain Stratification Symptom Symptoms the disease variety with COVID-19 Wuhan, China [DOI] 10.1371/journal.pcbi.1009183 PMC 바로가기 [Article Type] Research Article
Diplomatic Collaborative Solutions to Assure the Adoption of the European Single Market Amid the COVID-19 PandemicPublic Health Published on 2021-07-132022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] accelerate adoption binding Borders contributed coronavirus disease COVID-19 COVID-19 crisis European European Union greater Health health emergency and disaster risk management health information highlight implementation international cooperation lack likelihood limit Measures mitigate National pandemic platform public health crisis shown solution Transmission virus [DOI] 10.3389/fpubh.2021.662170 PMC 바로가기 [Article Type] Public Health
Herbal Medicine, Gut Microbiota, and COVID-19Pharmacology Published on 2021-07-072022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accelerate ACE2 acute respiratory syndrome affected amino acid malnutrition angiotensin converting enzyme caused complications coronavirus cough COVID-19 demonstrated diarrhea enteric symptom expressed Fever gastrointestinal tract gut microbiota Herb Herbal herbal medicine immune function intestinal cells intestinal flora intestinal inflammation intestinal mucosal barrier life threatening main receptor Medicine microbial mild flu-like symptoms modulate Mortality nausea organ patients with COVID-19 progression regulate Respiratory disease Respiratory virus infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus significantly symptoms of COVID-19 the disease treating COVID-19 Treatment understanding virus vomiting worldwide pandemic [DOI] 10.3389/fphar.2021.646560 PMC 바로가기 [Article Type] Pharmacology
The COVID-19 Data Portal: accelerating SARS-CoV-2 and COVID-19 research through rapid open access data sharingAcademicSubjects/SCI00010 Published on 2021-07-022022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, SARS, [키워드] accelerate acute respiratory syndrome Analysis consolidation coronavirus COVID-19 COVID-19 research dataset deaths European event facilitate identify Impact improvement independent information outbreak pandemic portal Release released required Research researcher resource responsible SARS-CoV-2 understanding virus Visualisation [DOI] 10.1093/nar/gkab417 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Empowering clinical research in a decentralized worldComment Published on 2021-07-012022-10-04 Journal: NPJ Digital Medicine [Category] 바이오마커, [키워드] accelerate acquisition Biomarkers Care clinical trial Clinical trial design COVID-19 pandemic DCT Empowering Health implementation implication improvement Interaction offer Regulation Research resources [DOI] 10.1038/s41746-021-00473-w PMC 바로가기 [Article Type] Comment
Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study7 개의 상업용 SARS-COV-2 빠른 시점 항원 테스트 비교 : 단일 센터 실험실 평가 연구Articles Published on 2021-07-012022-09-06 Journal: The Lancet. Microbe [Category] Communicable Disease, MERS, SARS, 치료기술, [키워드] 95% CI Abbott Abbott Panbio COVID-19 Ag Rapid Test accelerate Affair AgPOCT AgPOCTs analytical sensitivity Antigen Antigen point-of-care test assays Biocredit COVID-19 Ag Care cassette Cell culture clinical sample clinical samples Concentration coronavirus Coronaviruses COVID-19 COVID-19 Ag Respi-Strip cross-reactivity cumulative Cumulative specificities Cumulative specificity Decision making Endemic endemic human coronavirus energy evaluated False-positive results finding FIVE foundation funding generate HCoV HCoV-HKU1 supernatant HCoV‑229E HCoV‑HKU1 HCoV‑NL63 HCoV‑OC43 Healgen Healgen assay Healgen Coronavirus Ag Rapid Test Cassette Health Health care healthy volunteer healthy volunteers Horizon Infection infectious Laboratory limit of detection Melinda Gate Melinda Gates MERS MERS-CoV Ministry of Health Most patients nal von minden nal von minden NADAL COVID-19 Ag Test outlier overlap PanBio Pathogens Patient patients point-of-care positive public health quantified R-Biopharm ranged Rapid Rapid test RapiGEN RapiGEN BIOCREDIT COVID-19 Ag real-time RT-PCR recombinant SARS-CoV-2 nucleoprotein Research respiratory respiratory pathogen Respiratory pathogens Respiratory samples RIDA Roche Roche-SD Biosensor Roche-SD Biosensor SARS-CoV Rapid Antigen Test RT-PCR SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 testing SARS-CoV-2 viral load SARS-CoV-2 viral loads sensitivity Seven specificity stored respiratory sample stored respiratory samples Swab Symptoms Test test results tissue culture tissue culture supernatant tissue culture supernatants utility Viral Viral concentration Viral load viral loads virus concentration [DOI] 10.1016/S2666-5247(21)00056-2 PMC 바로가기 [Article Type] Articles