Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid ProdrugsArticle Published on 2021-07-262023-07-02 Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, [키워드] Antiviral agents Caco-2 cells calu-3 cells Huh7.5 cells lipid prodrugs PSC-derived human lung cells Remdesivir remdesivir nucleoside SARS-CoV-2 VERO E6 cells [DOI] 10.1128/AAC.01155-21 PMC 바로가기
Potent antiviral activity of Agrimonia pilosa , Galla rhois , and their components against SARS-CoV-2Article Published on 2021-07-232023-07-02 Journal: Bioorganic & Medicinal Chemistry [Category] SARS, [키워드] Agrimonia pilosa Galla rhois Antiviral agents AP, Agrimonia pilosa APRG64 APRG64, 50% EtOH aqueous extract mixture of AP and RG which ratio is 6 and 4 BSA, bovine serum albumin c.c., column chromatography COVID-19 COVID-19, Coronavirus disease 2019 DENV-2, dengue virus 2 DMEM, Dulbecco’s modified Eagle’s medium ELISA, enzyme-linked immunosorbent assay FBS, fetal bovine serum HCV, hepatitis C virus hpi, hours post-infection HSV-1, Herpes simplex virus type 1 IAV, influenza A virus LC/MS, liquid chromatography/mass spectrometry MEM, Eagle’s Minimum Essential Medium ODS, octadecyl SiO2 PFU, plaque-forming unit RG, Galla rhois SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEM, standard error of the mean SiO2, silica gel [DOI] 10.1016/j.bmc.2021.116329 PMC 바로가기 [Article Type] Article
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection프로테아제 억제제를 사용한 감염 후 치료는 치명적인 SARS-CoV-2 감염이 있는 생쥐의 생존을 증가시킵니다Comparative Study Published on 2021-07-202022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 신약개발, 진단, 치료제, [키워드] 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus ameliorated animal models Antiviral antiviral agent Antiviral agents antiviral drug Antiviral effect assays binding interaction binding interactions causative agent Cell culture change Compound coronavirus COVID-19 develop dose effective Efficacy enzyme evaluated global public health High-resolution histopathological human coronavirus human coronaviruses in vitro assays increase increased survival Infection inhibiting inhibitor inhibitory activity K18-ACE2 mice K18-hACE2 mice lethal infection Lung pathology mice Mild Postinfection potency protease Protease inhibitor protease inhibitors Replication reported respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients Significance significantly increased survival therapeutic efficacy therapeutic option transgenic mice treated Treatment variant Viral virus virus replication virus titer virus titers were used [DOI] 10.1073/pnas.2101555118 PMC 바로가기 [Article Type] Comparative Study
Plitidepsin: Mechanisms and Clinical Profile of a Promising Antiviral Agent against COVID-19Review Published on 2021-07-162022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] accelerate acting administration affected agent anti-SARS-CoV-2 anticipated Antiviral Antiviral agents Antiviral effect antiviral property aplidin B.1.1.7 variant clinical Clinical data clinical evidence Combination COVID-19 current database demonstrated Dexamethasone effective Efficacy Ex vivo hospital hospitalized COVID-19 patients hospitalized patients Host inhibiting interactions intravenous isoform knowledge lack lineages mechanism multicentre Multiple myeloma Patient Plitidepsin Population profile regimen Remdesivir safety profile SARS-CoV-2 Standard of care standard treatment suggested translation Treatment Trial viral load reduction Viral proteins [DOI] 10.3390/jpm11070668 PMC 바로가기 [Article Type] Review
Corrected QT interval in hospitalized patients with coronavirus disease 2019: Focus on drugs therapy2019년 코로나바이러스 감염증 입원환자 교정 QT 간격: 약물치료를 중심으로Observational Study Published on 2021-07-162022-09-11 Journal: Medicine [Category] SARS, 임상, 치료제, [키워드] 95% CI 95% confidence interval administration Antiviral agents Arbidol Biomarker Campus cardiac injury Chloroquine chloroquine/hydroxychloroquine confirmed COVID-19 case coronavirus disease Coronavirus disease 2019 COVID-19 severity creatine creatine kinase Creatine kinase-MB drug Drug administration Effect exhibited focus fraction hospitalized patient Hydroxychloroquine increased the risk Injury interferon less Lopinavir Lopinavir/ritonavir Mortality Odds ratio Patient patients treated peptide positively correlated Prognosis QT interval QTc QTc interval QTC prolongation receiving risk Ritonavir severity significant effect study cohort therapy treated Treatment troponin I Union Hospital West with COVID-19 Wuhan [DOI] 10.1097/MD.0000000000026538 PMC 바로가기 [Article Type] Observational Study
Progress and challenges in the comprehensive management of chronic viral hepatitis: Key ways to achieve the elimination만성 바이러스 간염의 포괄적인 관리의 진행 및 과제: 제거를 달성하는 주요 방법Review Published on 2021-07-142022-09-11 Journal: World journal of gastroenterology [Category] B형 간염, 치료제, [키워드] Antiviral Antiviral agents Antiviral treatment chronic Chronic Viral Hepatitis cirrhosis Complication coronavirus disease Coronavirus disease 2019 Direct direct antiviral agents direct-acting Elimination Elimination program groups Health Health Organization health problem Hepatitis hepatitis B Hepatitis B virus hepatitis C hepatitis C virus Hepatocellular carcinoma malaria management Mortality pandemic Prevent Progress Telemedicine Transmission Tuberculosis vaccination Viral hepatitis virus World Health Organization [DOI] 10.3748/wjg.v27.i26.4004 PMC 바로가기 [Article Type] Review
Methylene Blue has a potent antiviral activity against SARS-CoV-2 and H1N1 influenza virus in the absence of UV-activation in vitro메틸렌 블루는 시험 관내 UV- 활성화의 부재하에 SARS-COV-2 및 H1N1 인플루엔자 바이러스에 대한 강력한 항 바이러스 활성을 갖는다.Article Published on 2021-07-122022-09-01 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] absence Activation addition antiviral activity Antiviral agents approved blood product blood products blue Cell Clinical studies clinical study Concentration Degradation drug effective EMA European Medicines Agency evaluated examined FDA food genomic RNA H1N1 H1N1 influenza immune Immune Serum in vitro infected with SARS-CoV-2 Influenza influenza virus H1N1 malaria mechanism methemoglobinemia Methylene Methylene blue presence or absence safety profile SARS-CoV-2 SARS-CoV-2 infections serum shown Support therapeutic activity therapeutic efficacy Treatment UV light viral infection virucidal virus viruses [DOI] 10.1038/s41598-021-92481-9 PMC 바로가기 [Article Type] Article
Tagged extracellular vesicles with the RBD of the viral spike protein for delivery of antiviral agents against SARS-COV-2 infectionSARS-COV-2 감염에 대한 항바이러스제 전달을 위한 바이러스 스파이크 단백질의 RBD로 태그가 지정된 세포외 소포Article Published on 2021-07-102022-09-11 Journal: Journal of controlled release : official journal o [Category] SARS, 치료제, [키워드] accumulate ACE2 ACE2 receptor antiviral agent Antiviral agents approach binding domain Cell cellular cellular entry develop domain effective encapsulate endocytosed Express Extracellular extracellular vesicle Extracellular vesicles fusion hACE2 highlight in vivo Infection Interaction lung tissue lung tissues membrane membrane protein Membrane proteins modify molecular provide pseudovirus infection RBD Receptor binding domain receptor binding domain (RBD) Receptor-binding domain recognize required Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus siRNA siRNAs specific tissue specific tissues Spike protein spread of COVID-19 suppress Tagged target cells target tissue target tissues targeting the RBD the receptor-binding domain therapeutic potential Therapeutics tissue Transgenic mouse viral spike protein [DOI] 10.1016/j.jconrel.2021.05.049 PMC 바로가기 [Article Type] Article
Antiviral drugs arbidol and interferon alpha-1b contribute to reducing the severity of COVID-19 patients: a retrospective cohort study항 바이러스 약물 Arbidol 및 인터페론 알파 -1BResearch Published on 2021-07-082022-09-10 Journal: Virology Journal [Category] 치료제, [키워드] adjusted adjusted hazard ratio Antiviral agents antiviral drug antiviral drugs Arbidol China contribute control group COVID-19 COVID-19 pneumonia develop drug evaluate Hospital admission interferon Interferon alpha Interferon alpha-1b IQR Lopinavir Lopinavir–ritonavir Moderate COVID-19 objective P -value Patient patients with moderate Pneumonia primary endpoint progressed Recovery time reduce reduced reducing regression models Result retrospective cohort study ribavirin risk Ritonavir severity severity of COVID-19 severity of illness Severity rate significant difference significant differences significantly supplementary material Symptom symptom onset the patient Treatment [DOI] 10.1186/s12985-021-01617-w PMC 바로가기 [Article Type] Research
Estimation of the reproduction number of influenza A(H1N1)pdm09 in South Korea using heterogeneous modelsResearch Article Published on 2021-07-072023-06-06 Journal: BMC Infectious Diseases [Category] 신종인플루엔자, [키워드] Antiviral agents Influenza Reproduction number [DOI] 10.1186/s12879-021-06121-8 PMC 바로가기 [Article Type] Research Article