Concentration, Size Distribution, and Infectivity of Airborne Particles Carrying Swine VirusesResearch Article Published on 2015-08-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] aerosol analyzed Carrying cascade characterized collected Concentration demonstrated determine distribution enteric virus epidemic diarrhea geometric IAV indicated Infectivity influenza A virus information Particle pathogen PEDV polymerase chain quantified Quantitative reproductive reverse transcription RNA RT-PCR Survivability syndrome Transport transported Travel viability virus viruses [DOI] 10.1371/journal.pone.0135675 PMC 바로가기 [Article Type] Research Article
Transcriptome analysis of chicken kidney tissues following coronavirus avian infectious bronchitis virus infectionResearch Article Published on 2013-10-302022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Analysis analyzed Antiviral Apoptosis bronchitis cascade cause Cell compared conducted contagious contributed coronavirus cytokine differential expression differentially expressed gene down-regulated Gene Gene expression profiling Genes Host host defense response Host transcriptional response IBV IBV infection identify IL6 immune immune responses immune-related gene Infection infectious Infectious Bronchitis Virus Inflammatory response innate immune Interaction involved IRF1 KEGG pathway kidney kidney tissue kidney tissues knowledge mechanism Microarray molecular MOST MYD88 NFKB2 Ontology Pathogenesis pathway positive provided real-time RT-PCR Regulation related Result Signal transduction Stat1 the Coronaviridae Transcriptome transcriptome analysis up-regulated upper respiratory tract virus [DOI] 10.1186/1471-2164-14-743 PMC 바로가기 [Article Type] Research Article
Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors원추형 광수용체에서 Ranbp2의 특정 제거 시 광수용체 세포 유형 간의 고유하고 비정형적인 고유 및 외인성 세포 사멸 경로Research Article Published on 2013-06-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Ablation Activation acute transverse myelitis affecting Apoptosis approaches arise Author base cascade caspase caspase-3 caspase-7 caspase-9 cause Cell cell death clinical manifestations cone cone photoreceptor contribute death degenerate degeneration demise develop Diseases disintegration downstream driving event expression extrinsic Factor followed by found Gene Genes Genetic genetic defect hallmark healthy heterogeneous implicated intrinsic intrinsically manifestation mechanism membrane permeability metalloproteinase modulation molecular mosaic multifunctional protein Mutation Myelitis necrotic neural retina neurodegeneration neurodegenerative neurodegenerative disorders Neuron neurons neuroprotection PARP1 pathway Pathways photoreceptor photoreceptors pleiotropic progression progression of disease promote Protein Ranbp2 rod rod photoreceptor rod photoreceptors rods spatiotemporal Specific Stressor subcellular therapeutic thought transverse myelitis Trigger triggered Tumor Type undergo underlying disease underlying diseases up-regulation [DOI] 10.1371/journal.pgen.1003555 PMC 바로가기 [Article Type] Research Article
A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington’s Disease게놈 규모의 RNA-간섭 스크린은 헌팅턴병의 병리학적 특징으로 RRAS 신호를 식별합니다Research Article Published on 2012-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation addition Amino acid amino-terminus Analysis Author cascade caused Cell cellular cellular processe cellular processes component disease disorder Drosophila dysfunction effective ENCODE enzyme excitotoxicity farnesyltransferase FNTA found functional Glutamate Glutamine huntingtin Huntington's disease identify implicated in addition to increase in inhibitor Interaction Intervention involved Localization loss-of-function mammalian mechanism mechanisms mitochondrial mitochondrial dysfunction motor dysfunction mouse model mutant Mutation observé occur pathogenic pathway Pathways pharmacological PIN1 PLK1 Protein proteolysis RAF1 reduce reduced reducing repeated RNA interference RRAS Screen Signaling signaling pathway small molecule solubility suppress suppressed suppressor Therapeutic benefit These data Toxicity was performed [DOI] 10.1371/journal.pgen.1003042 PMC 바로가기 [Article Type] Research Article
MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic StressMK2-의존성 p38b 신호는 만성 스트레스 하에서 JNK 유도 세포자멸사로부터 Drosophila Hindgut Enterocytes를 보호합니다Research Article Published on 2011-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addressed affected antimicrobial peptides Apoptosis atrophy Author branch cascade Cell chronic complex component contribute damage damaged descendants Deterioration Diseases Drosophila Elimination Enterocyte enterocytes epithelial epithelium event form genetic analysis Gut Hindgut homeostasis Impaired induce integrity intestinal Intestinal diseases intestinal epithelium intestinal stem cell Intestinal stem cells JNK kinases leads less manifested pathogen Pathogens pathway peptides peptides) Prevent proliferation PROTECT Protective Protein protein kinase replaced REPLACED BY Replenishment required salt Signal transduction stem cell stem cells Stress Stressor stressors subsequent suppresse Trigger triggers upregulated upstream [DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article