COPD – Page 23 – Communicable Diseases Research

Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea

Article

Published on 2021-02-122022-10-29
Journal: Scientific Reports [Category] COVID-19, MERS,

Clinical characteristics and outcomes in women and men hospitalized for coronavirus disease 2019 in New Orleans

Research

Published on 2021-02-052022-10-28
Journal: Biology of Sex Differences [Category] COVID-19, MERS,

[키워드] 95%CI adjusted Admission adults hospitalized Asthma black BMI both sexes Care Characteristics Chronic kidney disease chronic obstructive clinical Clinical characteristics Comorbidities COPD coronavirus disease COVID-19 COVID-19 patient D-dimer death demographics determinant diabete digestive Dyspnea elevated equity exhibited fatigue ferritin Gender Healthcare system highlight hospital Hospitalized hypertension ICU IMV In-hospital death independent independent predictor intensive care Invasive mechanical ventilation Laboratory results magnitude management measure median age men Neutrophil-to-lymphocyte ratio New Orlean New Orleans obesity objective outcome participant Patient presenting symptoms prevalent pulmonary disease Rate Result setting Sex Sex difference supplementary material Symptom women
[DOI] 10.1186/s13293-021-00359-2 PMC 바로가기 [Article Type] Research

High-dose vitamin D versus placebo to prevent complications in COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial (CARED-TRIAL)

COVID-19 환자의 합병증을 예방하기 위한 고용량 비타민 D 대 위약: 무작위 대조 시험(CARED-TRIAL)을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-02-012022-09-10
Journal: Trials [Category] MERS, 임상,

[키워드] 1:1 24 hour 24 hours Admission age allergy ambient and vitamin D anticonvulsants assessment Asthma Blinding block Blood body mass body mass index breathing ambient air calcium cardiovascular cardiovascular disease carried charge childbearing childbearing age cholecalciferol chronic Chronic kidney disease clinical clinical complications clinical outcomes comparator Complete Complication computer-generated Contact COPD coronary artery bypass grafting country COVID-19 COVID-19 patient COVID-19 patients criteria current death diabete diabetes discharge discretion disease dissemination dose double-blind Effect element enrolled evaluate exclusion exclusion criteria failure first stage FIVE gel Gender grafting Haemodialysis High dose history hospital Hospital admission hospital discharge Hospitalization hypercalcemia hypertension IMPROVE include inclusion criteria Infection Informed consent initiated Intervention invasive invasive or non-invasive ventilation investigator investigator-initiated investigators Kidney disease Life expectancy liver malabsorption management matching placebo mechanical ventilation medication moderate multicentre Myocardial infarction Non-invasive non-invasive ventilation number objective occur Occurrence oral cholecalciferol oral intake Organ failure outcome oxygen oxygen saturation Oxygenation packaged pandemic PaO participant Patient patients performed Pharmacist pharmacological physiological effects Placebo placebo-controlled clinical trial Pneumonia Pragmatic Prevent Primary outcome protocol pulse oximetry random randomised randomised controlled trial randomization randomization ratio Randomized recorded recruited recruitment Registered reported Requirement researcher respiratory Respiratory outcome respiratory outcomes risk routine clinical practice RT-PCR Sample size sarcoidosis SARS-CoV-2 Sepsis sequence sequential design serum calcium Seven stages Standard status stratified study drug study medication Study protocol subject supplementary material total sample size Treatment Trial Trial registration Two-arm valve replacement variable Vitamin D Vitamin D supplementation was used website
[DOI] 10.1186/s13063-021-05073-3 PMC 바로가기 [Article Type] Letter

Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

흡입 코르티코스테로이드는 I형 인터페론의 억제를 통해 COPD에서 SARS-CoV-2 수용체 ACE2를 하향 조절합니다

Covid-19

Published on 2021-02-012022-09-10
Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Abstract ACE2 ACE2 expression ACE2, Angiotensin-converting enzyme-2 administration airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 BEC, Bronchial epithelial cell BSG, Basigin Cell culture changes chronic obstructive chronic obstructive pulmonary disease contribute COPD COPD, Chronic obstructive pulmonary disease coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 in patient COVID-19, Coronavirus disease 2019 disease downregulate Elastase entry receptor epithelial epithelial cell evaluate the effect evaluated exogenous IFN expression FP, Fluticasone propionate functional GR, Glucocorticoid receptor group human airway human airway epithelial ICS ICS therapy ICS, Inhaled corticosteroid ICSs IFN-α/β IFN-β IFNAR1 Inhaled inhaled corticosteroid inhaled corticosteroids interferon signaling ISG, Interferon-stimulated gene mechanism mice mouse model Mouse models objective obstructive pulmonary disease Patient PROTECT pulmonary disease receptor receptor ACE2 reduce expression reduced Result reversed risk SARS-CoV-2 entry receptor severe coronavirus disease severe COVID-19 sputum stratified susceptibility the SARS-CoV-2 therapy TMPRSS2, Transmembrane serine protease 2 type I type I interferon Viral viral entry viral infection were used
[DOI] 10.1016/j.jaci.2020.09.034 PMC 바로가기 [Article Type] Covid-19

Scope of adjuvant therapy using roflumilast, a PDE-4 inhibitor against COVID-19

Review article

Published on 2021-02-012022-10-05
Journal: Pulmonary pharmacology & therapeutics [Category] 임상,

COVID-19 Disease Course in Former Smokers, Smokers and COPD Patients

Physiology

Published on 2021-01-272022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

[키워드] acute respiratory syndrome caused chronic obstructive chronic obstructive pulmonary disease Comorbidities Comorbidity COPD coronavirus Course COVID-19 COVID-19 pandemic COVID-19 patient demonstrated Diabetes Mellitus disease disease severity former group Health higher risk Hospital admission hospital discharge Hospitalization implication increase in Infection Inflammatory marker no difference obesity Older age Other pandemic Patient patients patients with COVID-19 performed populations pulmonary disease Respiratory disease risk factor SARS-CoV-2 severe COVID-19 smoker Smokers smoking systemic arterial hypertension the disease
[DOI] 10.3389/fphys.2020.637627 PMC 바로가기 [Article Type] Physiology

National Trends and Disparities in Health Care Access and Coverage Among Adults With Asthma and COPD: 1997-2018

Research article

Published on 2021-01-232022-10-05
Journal: Chest [Category] 비임상,

[키워드] 2.05 health policy 95% CI access Act adjusted airways disease Asthma behavioral science Care COPD Coverage described Disparities disparity drug examined financing Health implementation IMPROVE interview lack linear medication organization peaking performed Probability proportion recession Regression Result reversed rising study period survey trend worsened
[DOI] 10.1016/j.chest.2021.01.035 [Article Type] Research article

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

Immunology

Published on 2021-01-192022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

[키워드] acute respiratory syndrome adaptive allergen apoptotic cells Asthma Cell chronic obstructive clearance COPD coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense disease example excessive inflammatory response function HIV homeostasis Human immunodeficiency virus immune system Immunomodulatory agents immunopathology immunoregulation increased risk indicated infections Inflammation inflammatory disease Inflammatory response Inflammatory responses influenza A virus innate immune lung maintain modulate modulating molecule mucosal neutralize Neutralizing noxious offer Particles pathology Prevent property Protein pulmonary disease recombinant recombinant fragment of human SP-D (rfhSP-D) respiratory syncytial virus respiratory viral infection RSV SARS-CoV-2 severe acute respiratory syndrome Coronavirus 2 (2019-nCoV) shown strain surfactant surfactant protein A Surfactant protein D therapeutic therapeutic potential viral infection viral infections virus with COVID-19
[DOI] 10.3389/fimmu.2020.622598 PMC 바로가기 [Article Type] Immunology

COVID-19, COPD, and AECOPD: Immunological, Epidemiological, and Clinical Aspects

Medicine

Published on 2021-01-182022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] acute exacerbation acute respiratory distress acute respiratory syndrome adverse impact ARDS aspect cardiovascular condition cause chronic obstructive cigarette smoke (CS) clinical clinical condition clinical feature COPD coronavirus 2 COVID-19 Effect Endothelium epidemiological data heterogeneous identify immune system longitudinal study morbidity morbidity and mortality outcome Patient Prevalence Prevent progression pulmonary disease representing respiratory infections responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe disease susceptibility syndrome the disease therapeutic target therapy Vascular endothelium virus
[DOI] 10.3389/fmed.2020.627278 PMC 바로가기 [Article Type] Medicine

Prognostic Factors at Admission for In-Hospital Mortality from COVID-19 Infection in an Older Rural Population in Central Spain

Article

Published on 2021-01-162022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,