Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants모델링 형태 상태 역학 및 SARS-COV-2 스파이크 단백질 변이체에 대한 감염에 대한 역할Research Article Published on 2021-08-052022-08-13 Journal: PLoS Computational Biology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 501.V2 ACE2 alternative methods B.1.1.7 calculate cell entry computational method conformational COVID-19 D614G decrease facilitate flexibility glycine helping human ACE2 receptor identify increase in Infection K417 knowledge less matter mechanism molecular mechanism molecular mechanisms multiple mutation multiple mutations Mutation N501Y N501Y mutation new strain normal mode analysis open Pandemics predict proof proof of concept Protein public health residue residues resource SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein several variant several variants Simulation specific mutation specific mutations spike Spike protein Strains Surveillance the SARS-CoV-2 the Spike transition probabilities transition probability treat variant variants Viral viral entry virus [DOI] 10.1371/journal.pcbi.1009286 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic VariantsResearch Article Published on 2021-08-042022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] Amino acid Analysis antibody applied cell tropism Characteristics collected Consensus consensus genome consensus sequences COVID-19 D614G domain Epidemic evaluate Evolution Evolution of SARS-CoV-2 feature functional Genes Genetic genetic diversity Genome Haplotype Host host range hosts immune system independent indicated information Intervention introduced mutant mutant spectrum Mutation Nasopharyngeal swab nasopharyngeal swabs Next-generation sequencing NGS nine Patient platform pool Population Positive selection predict predominant previous study produced provided Quasispecies quasispecy replications RNA RNA virus S2 domain SARS-CoV-2 selective sequence sequenced significantly lower spike gene spike glycoprotein sputum Sputum sample Stool Substitution suggested variant variants Variation variations [DOI] 10.1128/Spectrum.00261-21 PMC 바로가기 [Article Type] Research Article
Transformations, Lineage Comparisons, and Analysis of Down-to-Up Protomer States of Variants of the SARS-CoV-2 Prefusion Spike Protein, Including the UK Variant B.1.1.7Research Article Published on 2021-08-042022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome African alanine substitution Analysis analyzed B.1.1.7 B.1.1.7 variant B.1.351 variant Betacoronavirus betacoronaviruses binding Care change characterized coronavirus COVID-19 Critical D614G Deletion demonstrated determine dominant examined example feature functional Genetic Genome Health homologous homology identify Including independent infect cells Infection information Interaction Lineage lineages MERS-CoV middle molecular monitoring mutant Mutation N501Y Outbreaks pandemic Phylogenetic Phylogenetic analysis prefusion Protein RBD related virus related viruses residue respiratory syndrome coronavirus responses SARS-CoV-2 SARS-CoV-2 variant sequence similarity South specific mutation spike Spike protein state the receptor-binding domain the SARS-CoV-2 the Spike transformations Transmission trimeric understanding Vaccine variant variants viral outbreak virus viruses [DOI] 10.1128/Spectrum.00030-21 PMC 바로가기 [Article Type] Research Article
A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agents항 바이러스제를 평가하기 위해 공기 액체 계면에서 1 차 인간 상피 세포에서 강력한 SARS-COV-2 복제 모델Article Published on 2021-08-012022-09-10 Journal: Antiviral Research [Category] 신약개발, 치료제, [키워드] added Air-liquid interface airway epithelial cell Antiviral antiviral agent antivirals apical side approved AT-511 AT-527 basolateral side Cell clinical development clinical testing collected Culture culture medium D614G dose-dependent inhibition drug EIDD-1931 epithelial cells GS-441524 human epithelial cell IFN in vitro infectious virus titer infectious virus titers inhibit inhibitor medium molnupiravir nucleoside parent nucleoside primary cell Primary human airway epithelial cells Protein Remdesivir remdesivir) replicate robust SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 replication selected shown tracheal Treatment Viral viral replication Viral RNA virus virus titers were infected [DOI] 10.1016/j.antiviral.2021.105122 PMC 바로가기 [Article Type] Article
A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agentsArticle Published on 2021-08-012022-10-27 Journal: Antiviral Research [Category] COVID-19, [키워드] added Air-liquid interface airway epithelial cell Antiviral antiviral agent antivirals apical side approved AT-511 AT-527 basolateral side Cell clinical development clinical testing collected Culture D614G dose-dependent inhibition drug EIDD-1931 GS-441524 human epithelial cell IFN in vitro infectious virus titer inhibit inhibitor medium molnupiravir parent nucleoside Primary human airway epithelial cells Protein Remdesivir replicate robust SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 replication selected shown tracheal Treatment viral replication Viral RNA virus were infected [DOI] 10.1016/j.antiviral.2021.105122 PMC 바로가기 [Article Type] Article
A robust SARS-CoV-2 replication model in primary human epithelial cells at the air liquid interface to assess antiviral agentsArticle Published on 2021-08-012022-10-27 Journal: Antiviral Research [Category] Coronavirus, COVID-19, SARS, [키워드] added Air-liquid interface airway epithelial cell Antiviral antiviral agent antivirals apical side approved AT-511 AT-527 basolateral side Cell clinical development clinical testing collected Culture D614G dose-dependent inhibition drug EIDD-1931 GS-441524 human epithelial cell IFN in vitro infectious virus titer inhibit inhibitor medium molnupiravir parent nucleoside Primary human airway epithelial cells Protein Remdesivir replicate robust SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 isolates SARS-CoV-2 replication selected shown tracheal Treatment viral replication Viral RNA virus were infected [DOI] 10.1016/j.antiviral.2021.105122 PMC 바로가기 [Article Type] Article
Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach분자 도킹 및 MM/GBSA 접근법을 통한 SARS-CoV-2 스파이크 단백질의 비동의적 돌연변이 및 ACE2 수용체와의 상호작용 조사Article Published on 2021-08-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor acute respiratory distress acute respiratory distress syndrome angiotensin angiotensin-converting enzyme 2 approach approaches binding binding affinity binding free energy bioinformatics caused coagulation dysfunction COVID-19 D614G develop disease docking domain examined free energy G476S help Host human cell human cells in viral Infection infectious interact Interaction investigated investigation L18F MDs MERS-CoV molecular docking molecular dynamics Molecular dynamics simulation molecular mechanism mutant mutants Mutation N501Y nonsynonymous mutation Nonsynonymous mutations pathogenic pathological mechanism Perspective RBD receptor Receptor-binding domain researcher respiratory distress responsible reveal S-protein SAR-CoV-2 SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic screened Septic shock spike Spike protein spike-protein stability syndrome the spike protein Treatment viral disease viral infection virulent [DOI] 10.1016/j.compbiomed.2021.104654 PMC 바로가기 [Article Type] Article
Assessment of basic reproduction number (R 0), spatial and temporal epidemiological determinants, and genetic characterization of SARS-CoV-2 in Bangladesh방글라데시 SARS-CoV-2의 기본 생식 수(R 0), 공간 및 시간 역학 결정인자 및 유전적 특성 평가Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 치료기술, 치료법, [키워드] Analysis assessment B.1 B.1.1 basic reproduction number calculated Case fatality rate circulating clade Cluster continuous monitoring country COVID-19 cumulative D614G detect determinants distribution effective Effectiveness epidemiological evaluate exponential growth Fatality rate Genetic Genome genomic Genomic analysis Genomic surveillance highest incidence of COVID-19 Infection isolates Lineage Local molecular molecular characteristics Molecular epidemiology Mutation Non-synonymous NSP11 NSP2 Nsp9 nucleocapsid nucleocapsid protein P323L pandemic Pangolin lineage performed Phylogenetic Phylogenetic analysis prediction predominant projection Protein RdRP SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 strain sequence spike Spread strain Strains subsequent Surveillance Transmission dynamics unique vaccination variants of SARS-CoV-2 variations virus was recorded were recorded [DOI] 10.1016/j.meegid.2021.104884 PMC 바로가기 [Article Type] Article
SARS-CoV-2 genomic surveillance in Costa Rica: Evidence of a divergent population and an increased detection of a spike T1117I mutation코스타리카의 SARS-CoV-2 게놈 감시: 다양한 인구의 증거 및 스파이크 T1117I 돌연변이의 검출 증가Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] accumulating Analysis analyzed B.1 B.1.1 Cell clade Costa Rica country Course COVID-19 COVID-19 case COVID-19 pandemic D614G distribution Effectiveness evidence of feature Frequency Genome Genome sequencing genomic Genomic surveillance Genomic variability GISAID GISAID reported sequence increase in Infection Latin America less Lineage lineages Local Mutation no difference no differences nucleotide oligomerization ORF8 pandemic Pangolin lineage predicted predominant Prevalence Protein regions reported responsible SARS-CoV-2 SARS-CoV-2 genomic surveillance SARS-CoV-2 pandemic SARS-CoV-2 sequences sequence sequences Sequencing severity single nucleotide Spike protein Surveillance the SARS-CoV-2 the Spike Transmissibility Vaccine variant variant calling analysis variants virus whole genome whole-genome [DOI] 10.1016/j.meegid.2021.104872 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune seraResearch Article Published on 2021-07-302022-10-28 Journal: Precision Clinical Medicine [Category] COVID-19, [키워드] addition amino acid substitution B.1.617 B.1.617.1 binding biologic comparable Convalescent patients COVID-19 D614G dominant variant E484Q ELISA assay Evolution of SARS-CoV-2 Factor Health authority healthy highlight immune implication India Infectivity involved L452R mRNA vaccine neutralization neutralization activity neutralizing antibody non-human primate non-human primates Non-synonymous outbreak Protein Pseudotyped virus RBD Receptor binding domain reduction in SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant sera the antibody the RBD the spike protein vaccination Vaccine development vaccinee variant virus [DOI] 10.1093/pcmedi/pbab016 PMC 바로가기 [Article Type] Research Article