Linked nosocomial COVID-19 outbreak in three facilities for people with intellectual and developmental disabilities due to SARS-CoV-2 variant B.1.1.519 with spike mutation T478K in the NetherlandsSARS-COV-2 변형으로 인한 지적 및 발달 장애가있는 사람들을위한 3 개의 시설에서 연결된 병원체 CovID-19 발생 B.1.1.519 네덜란드에 스파이크 돌연변이 T478K가있는Research Published on 2022-02-102022-09-10 Journal: BMC Infectious Diseases [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] Asymptomatic attack attack rate B.1.1.519 variant Characteristics circulating variants clinical clinical information confirmed case COVID-19 infection developmental developmental disabilities died dominant Evidence Genotype Hospitalized increased risk index individual Infection prevention Infection prevention and control information Intellectual and developmental disability intrinsic measure Median viral load morbidity morbidity and mortality Mortality Netherland Netherlands no significant difference nosocomial COVID-19 notification Observed outbreak PCR Prevalence protocol reported Result SARS-CoV-2 SARS-CoV-2 variant Sequencing significant difference specimen spike mutation submitted subsequent supplementary material Support Surveillance T478K T478K spike mutation Travel vaccination against COVID-19 variant Viral [DOI] 10.1186/s12879-022-07121-y PMC 바로가기 [Article Type] Research
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunitySARS-CoV-2 변이 스파이크 에피토프의 인식에서 벗어나 T 세포 면역의 전반적인 보존Article Published on 2022-02-092022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] Ability to protect Affect African Beta Beta variant CD4 CD4 T cells CD8 CD8 T cell CD8 T cell responses COVID-19 patient detectable dominant Efficacy epitope Epitopes escape explain First wave first-wave immune evasion Immunity immunogenic mounted mutated neutralization neutralizing antibody observation Patient patients peptide peptides preserved proportion PROTECT Recognition recognize Region regions Reinfection residue response retained robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 severe disease South spike epitope spike epitopes spike mutation spike mutations T cell T cell response T cell responses T cells tested Vaccine vaccine efficacy variant wild-type Wuhan strain [DOI] 10.1126/scitranslmed.abj6824 PMC 바로가기 [Article Type] Article
Identification of immunodominant epitopes on nucleocapsid and spike proteins of the SARS-CoV-2 in Iranian COVID-19 patients이란 COVID-19 환자에서 SARS-CoV-2의 뉴클레오캡시드 및 스파이크 단백질에 대한 면역우성 에피토프 식별Article Published on 2022-02-092022-09-11 Journal: Pathogens and disease [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Amino acid amino acids Analysis Antibody Response binding conformational COVID-19 COVID-19 infection COVID-19 patient determine Diagnosis diagnostic Disulfide domain dominant ELISA entire sequence enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes experiment healthy subject identification IgG response immunodominant epitope immunodominant epitopes immunogenic Immunotherapy information life-threatening linear epitopes moderate no significant difference no significant differences nucleocapsid overlapping pandemic Patient pepscan peptide peptide pools peptides Protein RBD RBD of SARS-CoV-2 reactivity Receptor binding domain Receptor-binding domain recombinant RBD protein reduced SARS-CoV-2 SARS-CoV-2 virus sera significant differences significantly lower Spike protein structural proteins target targets the RBD the SARS-CoV-2 Viral was performed western blotting [DOI] 10.1093/femspd/ftac001 PMC 바로가기 [Article Type] Article
Self-reported symptom study of COVID-19 chemosensory dysfunction in MalaysiaArticle Published on 2022-02-082022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] accounted adult COVID-19 patient aetiology alteration Analysis Asian changes in chemesthesis chemosensory Cohort conducted COVID-19 cross-sectional diagnosed with COVID-19 disorder dominant dysfunction entire cohort Epidemiology implicated independent predictor loss of appetite Malaysia mechanism multicentre nasal Olfactory system Patient patients Perceived Population presenting presenting symptom Prevalence proportion questionnaire reduction in reported sensorineural Signs and symptoms Symptom these symptoms Variation viral infection viral strains widespread [DOI] 10.1038/s41598-022-06029-6 PMC 바로가기 [Article Type] Article
Descriptive comparison of admission characteristics between pandemic waves and multivariable analysis of the association of the Alpha variant (B.1.1.7 lineage) of SARS-CoV-2 with disease severity in inner London전염병 파동 사이의 입원 특성과 SARS-COV-2의 알파 변이체 (B.1.1.7 계보)의 연관성 분석 및 런던 내부의 질병 중증도의 다변량 분석.Infectious Diseases Published on 2022-02-082022-09-10 Journal: BMJ Open [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] 1.26 95% CI Admission age aligned Alpha Alpha variant Analysis association B.1.1.7 B.1.1.7 lineage Characteristics circulating clinical Clinical data Cohort collected current defined disease severity dominant Electronic health record Epidemiology Health health record healthcare hospitalised hypoxia Infection infection control Intervention isolate Laboratory Logistic regression London multisite multivariable analysis Multivariate analysis nosocomial obesity on admission pandemic positive public health Result risk factor Risk factors SARS-CoV-2 SARS-CoV-2 RNA sequence sequenced severity Severity of disease variant Viral viral genome sequence Virology Wave [DOI] 10.1136/bmjopen-2021-055474 PMC 바로가기 [Article Type] Infectious Diseases
T Cell Response following Anti-COVID-19 BNT162b2 Vaccination Is Maintained against the SARS-CoV-2 Omicron B.1.1.529 Variant of ConcernBrief Report Published on 2022-02-082022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] addition Administered affected antigenic drift B.1.1.529 BNT162b2 carried Cell cells collected comparable concern COVID-19 COVID-19 pandemic dominant Efficacy eight ELISPOT examined fluorescent FluoroSpot form healthy volunteer IL-10 IL-4 Immunity individuals Maintained manifested mononuclear cell omicron overlapping PBMC peptide Peripheral blood progression Protective protective immunity reactivity reduced representing response SARS-CoV-2 SARS-CoV-2 virus variants secreting severe disease manifestations significantly Spike protein stimulated T cell T cell response T cell responses tested Th1 response the SARS-CoV-2 vaccination Vaccines variant variants of concern VoC wild-type Wuhan-1 [DOI] 10.3390/v14020347 PMC 바로가기 [Article Type] Brief Report
The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemicOmicron 변이체는 항체 매개 중화에 대해 높은 내성을 보입니다: COVID-19 전염병 통제에 대한 시사점Article Published on 2022-02-032022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody BNT162b2 ChAdOx1 convalescent patient Convalescent patients COVID-19 pandemic Delta delta variant dominant dose evade Heterologous higher efficiency immune immune evasion immunization individual Infection Mutation neutralization of BNT162b2 omicron Omicron variant PROTECT raised remained SARS-CoV-2 severe disease Sotrovimab spike Spike protein Spread susceptible the SARS-CoV-2 therapeutic vaccination Vaccine variant Viral viral spike protein virus [DOI] 10.1016/j.cell.2021.12.032 PMC 바로가기 [Article Type] Article
Co-circulation of SARS-CoV-2 Alpha and Gamma variants in Italy, February and March 20212021년 2월과 3월 이탈리아에서 SARS-CoV-2 알파 및 감마 변종 공동 유통Research Published on 2022-02-032022-09-10 Journal: Eurosurveillance [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] Alpha Alpha variant assumed circulating clinical sample co-circulation competing Complete conducted cross-protection dominant Gamma genomic immune evasion Infection Italian territory Italy Lineage majority mathematical mathematical model National Prevalence proportion ranged remained replaced Result SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variant of concern Strains Surveillance the mean Transmissibility variant variants of SARS-CoV-2 viral strains VoC [DOI] 10.2807/1560-7917.ES.2022.27.5.2100429 PMC 바로가기 [Article Type] Research
First Chinese ultraviolet–visible hyperspectral satellite instrument implicating global air quality during the COVID-19 pandemic in early 2020Article Published on 2022-02-022022-10-04 Journal: Light, Science & Applications [Category] 치료기술, [키워드] Algorithm America anthropogenic Atmospheric optics Beijing change changes in China Chinese Compound country COVID-19 pandemic dominant effective EMI emission Emissions Europe example formaldehyde GDP Government Guangzhou had more indicated instrument investigated lack lockdown majority measure monitoring New notable Optical spectroscopy pandemic Prevent reduction in reductions in Research resulting retrieved Shanghai significant decrease Spread suggested sulfur dioxide Tokyo trace Variation VOCs Wuhan [DOI] 10.1038/s41377-022-00722-x PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection in free-ranging white-tailed deer방목하는 흰꼬리사슴의 SARS-CoV-2 감염Article Published on 2022-02-012022-09-11 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 조류인플루엔자, 치료기술, [키워드] Amino acid amino acid substitution amino acid substitutions animal reservoir animals deer dominant Evolution Host Human humans infection with SARS-CoV-2 MONITOR nasal swab nasal swabs Odocoileus one health ORF1 pathway Real-time PCR Receptor-binding domain reverse transcription SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2 viruses Spike protein susceptible the receptor-binding domain the spike protein Transmission transmitted USA virus viruses were infected white-tailed deer wildlife [DOI] 10.1038/s41586-021-04353-x PMC 바로가기 [Article Type] Article