The Role of Pathogens and Anti-Infective Agents in Parkinson’s Disease, from Etiology to Therapeutic ImplicationsReview Published on 2021-10-232024-09-02 Journal: Journal of Parkinson's Disease [Category] 대상포진, [키워드] Drug repurposing gut microbiota Infection Neuroinflammation Parkinson’s disease [DOI] 10.3233/JPD-212929 PMC 바로가기 [Article Type] Review
Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replicationReview Published on 2021-10-202023-06-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), MERS, SARS, [키워드] Streptomyces avermitilis Antiviral Cytokine storm Drug repurposing Importin heterodimer complex inhibition STAT3 Treatment Viral 3CLpro [DOI] 10.1016/j.bbadis.2021.166294 PMC 바로가기 [Article Type] Review
Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19약물 용도는 11 배의 질병을 향상시키고 Covid-19에 적용되는 네트워크 모듈 표적에 의해 강화 될 수 있습니다.Article Published on 2021-10-192022-08-31 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis applied average Computational biology and bioinformatics Coverage COVID-19 dependent on disease drug Drug discovery Drug repurposing drug target drugs fostamatinib Genes highest highlight IMPROVE increase increase in indication network analysis offer similarity target protein target proteins therapeutic [DOI] 10.1038/s41598-021-99721-y PMC 바로가기 [Article Type] Article
Personalized therapy: can it tame the COVID-19 monster?맞춤 요법 : Covid-19 Monster를 길들일 수 있습니까?Review Published on 2021-10-152022-09-10 Journal: Personalized Medicine [Category] SARS, 신약개발, 치료제, [키워드] adverse effect adverse effects age antivirals Biomarker Biomarkers clinical trials COVID-19 COVID-2019 drug Drug repurposing drug toxicity drugs genetic determinants Infection knowledge morbidity and mortality mortality rates pathogen Personalized medicine precision therapy SARS-CoV-2 SARS-COV-2 infection Sex subjects therapeutic efficacy therapy thought Toxicity virus zoonotic [DOI] 10.2217/pme-2021-0077 PMC 바로가기 [Article Type] Review
Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro시험 관내 SARS-COV-2의 치료를위한 이온 채널 억제제 아만타딘, 메만 틴 및 리만타딘의 효능Brief Report Published on 2021-10-152022-09-10 Journal: Viruses [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adamantane amantadine antagonistic Antiviral barrier to escape cells combination treatment coronavirus COVID-19 Drug repurposing effective Efficacy followed by hepatitis C virus p7 inhibitor hepatoma highest Huh7.5 in vitro inhibitor inhibitors ion-channel inhibitor lung carcinoma Memantine Remdesivir respiratory Rimantadine SARS-CoV-2 selectivity index severe acute respiratory syndrome Coronavirus Treatment VeroE6 cells Viral viral entry viral escape [DOI] 10.3390/v13102082 PMC 바로가기 [Article Type] Brief Report
Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive PatientsSARS-COV-2- 양성 환자의 비 인두 면봉으로부터의 숙주 세포에서 수입 알파 및 약물 표적 발현 프로파일 링에 대한 Ivermectin 및 Atorvastatin의 효과Article Published on 2021-10-152022-09-10 Journal: Viruses [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] Actin Affect alteration analyzed antihelmintic drug atorvastatin Cdc42 cellular Combination concentrations confocal microscopy COVID-19 COVID-19 patient COVID-19 patients cytoplasmic distribution drug Drug repurposing drug target drugs Effect expression function Gene Expression host cell host cell antiviral response host cells impair Importin in vitro model Infection inhibit involved Ivermectin KPNA3 KPNA5 KPNA7 KPNB1 lipophilic statin Localization mechanism Nasopharyngeal swab nasopharyngeal swabs NF-κB NF-κB activation Non-COVID-19 patients nuclear Nuclear localization Pathogenesis Patient pleiotropic effect poly(I:C) Profiling Result Rho GTPase Rho GTPases RHOA RNA viruses SARS-CoV-2 SARS-COV-2 infection Signaling target transcriptional Transport Treatment triggered Vesicle Viral viral double-stranded RNA [DOI] 10.3390/v13102084 PMC 바로가기 [Article Type] Article
Viral polymerase binding and broad-spectrum antiviral activity of molnupiravir against human seasonal coronavirusesArticle Published on 2021-10-022023-06-14 Journal: Virology [Category] MERS, [키워드] Drug repurposing molnupiravir RdRP seasonal coronavirus [DOI] 10.1016/j.virol.2021.09.009 PMC 바로가기 [Article Type] Article
Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics SimulationsArticle Published on 2021-10-022022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] 3CLpro ADMET alcohol Analysis approach backbone binding free energy binding interactions Bioavailability carried combating complex Compound COVID 19 COVID-19 disease docked docking study drug Drug repurposing drugs duplication Dynamic simulation Dynamics effective fluctuation identify in silico indicated inhibiting Interaction Ligand medical need molecular molecular docking molecular dynamics Patchouli patchouli alcohol pharmacokinetic PLPro protein-ligand Research SARS-CoV-2 SARS-COV-2 infection selected Simulation target tomatidine Toxicity Treatment virus [DOI] 10.3390/ijms221910693 PMC 바로가기 [Article Type] Article
Repurposing drug molecule against SARS-Cov-2 (COVID-19) through molecular docking and dynamics: a quick approach to pick FDA-approved drugs분자 도킹 및 역학을 통한 SARS-COV-2 (COVID-19)에 대한 약물 분자를 재사용하는 것 : FDA 승인 약물을 선택하는 빠른 접근Article Published on 2021-10-022022-08-31 Journal: Journal of molecular modeling [Category] MERS, SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome Amprenavir approach approved bind Cefoperazone clinical trial Computational methods conserved coronavirus COVID-19 Diagnosis Diosmin drug Drug repurposing Efficacy effort Evidence experimental validation FDA-approved drug FDA-approved drugs functional protein Health authority inefficient inhibit inhibitor inhibitors interactions International international health involved limitations molecular docking molecular dynamics Molecular dynamics simulation nadide Novel coronavirus performed protease protease inhibitors provide quarantine repurposing residue residues respiratory Riboflavin SARS-CoV-2 SARS-CoV-2 main protease Severe acute respiratory syndrome the patient the SARS-CoV-2 therapeutic therapeutic option therapeutic use troxerutin Vaccine Virtual screening [DOI] 10.1007/s00894-021-04923-w PMC 바로가기 [Article Type] Article
Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatmentsReview Published on 2021-10-012022-10-04 Journal: Infectious diseases (London, England) [Category] SARS, 신약개발, [키워드] acute COVID-19 Adults Affect Autoimmunity Brain cell activation Chest children chronic fatigue syndrome cognitive conditions cough COVID COVID cases COVID-19 CRP D-dimer disease severity driven by Drug repurposing Dyspnoea Evidence fatigue female FIVE group headache help Hospitalized immune dysregulation include Inflammation joint Long Long COVID Long-haul COVID-19 lung Lymphocyte count Mental myalgia orthostatic Other pathophysiology Post-COVID-19 syndrome Psychiatric disorders rehabilitation reported required Research risk factor Risk factors Sex specific biomarker Support survivor Symptom Symptoms syndrome Tachycardia therapeutic drug tissue damage Treatment viral persistence while widespread [DOI] 10.1080/23744235.2021.1924397 PMC 바로가기 [Article Type] Review