Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial CellsImmunology Published on 2020-06-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Analysis analyzed antiviral action antiviral immunity approach carried clinically Comprehensive contribute COVID-19 current dataset datasets develop diagnostic differentially expressed gene drug early phase ENhance epithelial cell Human identify IFITM3 induce Infection Interaction interferon-induced transmembrane proteins mammal management modify mRNA expression pandemic Repurposed drugs Research SARS-CoV SARS-CoV-2 target therapeutic interventions transcriptomic upregulated Vaccine Valproic acid [DOI] 10.3389/fimmu.2020.01372 PMC 바로가기 [Article Type] Immunology
Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics급성호흡곤란증후군의 간엽줄기세포치료제: 기초부터 임상까지Review Published on 2020-06-092022-09-10 Journal: Protein & Cell [Category] MERS, SARS, 비임상, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar fluid clearance anti-apoptotic Anti-inflammatory approaches ARDS Bacterial breath caused Cell cell damage Cell therapy China clinical study clinics coronavirus coronavirus disease COVID-19 COVID-19 patient develop disease disrupt distal Effects Efficacy ENhance epithelial epithelial cell event Extracellular vesicles Factor high mortality intrinsic limit lung mechanism mesenchymal stem cell Mesenchymal stem cells morbidity MSC MSC therapy multiple organ failure Novel coronavirus novel coronavirus disease occurred optimization Organ failure organ injury paracrine pathophysiological patients with ARDS Pneumonia promote pulmonary endothelial respiratory respiratory distress SARS-CoV-2 SARS-CoV-2-infected patient SARS-CoV-2-infected patients severe acute respiratory syndrome Coronavirus severe pneumonia stem cell supportive care survival syndrome therapeutic therapy variety [DOI] 10.1007/s13238-020-00738-2 PMC 바로가기 [Article Type] Review
Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesisResearch Article Published on 2020-05-132022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 치료제, [키워드] adaptive Adaptive immune response Adaptive immunity Analysis antiviral drugs applied cause caused complications coronavirus COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Disease progression early phase epithelial cell Host immune response Immunity implication Infection Influenza Influenza virus innate immune response Innate immunity Interaction lung mathematical Mortality opposite pandemic Pathogenesis patients potential treatment option SARS‐CoV‐2 virus SARS‐CoV‐2 severity Suppressing target cell‐limited model the timing viral clearance Viral load viral pathogenesis virus viruses [DOI] 10.1002/jmv.25866 PMC 바로가기 [Article Type] Research Article
Choroid plexus and the blood–cerebrospinal fluid barrier in diseaseReview Published on 2020-05-062022-10-31 Journal: Fluids and Barriers of the CNS [Category] COVID-19, [키워드] addition affecting Autoimmune disease Blood–cerebrospinal fluid barrier Brain capillary carcinoma Central nervous system Choroid plexus CNS Critical Diagnostic method disease epithelial cell homeostasis Inflammatory diseases integrity involved knowledge multiple sclerosis neurodegenerative Neurodegenerative disease pathogen pathophysiology penetration recent Research shown stroke Structure tight junction trauma Treatment [DOI] 10.1186/s12987-020-00196-2 PMC 바로가기 [Article Type] Review
SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary InflammationArticle Published on 2020-04-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activated Analysis Antiviral agents binding activity CCL5 chemokine coronavirus CXCL10 demonstrated Diffuse alveolar damage domain epithelial cell examined expression G-quadruplex human lung in vitro indicated infiltration Inflammatory response inhibitor initiate Lung injury lung tissue macrodomain Macrophage mice modulated Monocytes NLRP3 NLRP3 inflammasome plasmids potential therapeutic target protein 3 pulmonary pulmonary inflammation respiratory SARS pathogenesis SARS-coronavirus SARS-CoV SARS-CoV unique domain (SUD), CXCL10 significantly Symptoms triggered unique up-regulated wild type [DOI] 10.3390/ijms21093179 PMC 바로가기 [Article Type] Article
Sex-Specific SARS-CoV-2 Mortality: Among Hormone-Modulated ACE2 Expression, Risk of Venous Thromboembolism and Hypovitaminosis DCommentary Published on 2020-04-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 ACE2 expression ACE2: venous thromboembolism activated acute respiratory syndrome addition adipose appear coronavirus COVID-19 decrease deficiency disease down-regulated enzyme epidemiological epithelial cell Evidence expression female Frequency Gender differences Genetic predisposition greater help hypertensive hypovitaminosis increase Intervention involved kidney male men mice modulate mortality rate Myocardial Myocardium Orchiectomy patients with COVID-19 penetration predisposition presence of comorbidity SARS-CoV-2 SARS-CoV2 sex hormone shown susceptibility the spike protein tissue Treatment Venous Thromboembolism virus vitamin D deficiency worse prognosis [DOI] 10.3390/ijms21082948 PMC 바로가기 [Article Type] Commentary
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosaArticle Published on 2020-02-242022-10-29 Journal: International Journal of Oral Science [Category] COVID-19, SARS, [키워드] 2019-nCoV ACE2 ACE2 receptor analyzed annotation Atla Biomarkers CAP Cell Clinical practice collected database dataset demonstrated Diseases epithelial cell Evidence explained expressed expression Final high risk host cell receptor identify independent Infection mechanism mucosa oral mucosa organ profile proportion provided receptor reported RNA-Seq single-cell transcriptome susceptibility tissue tongue virus were used [DOI] 10.1038/s41368-020-0074-x PMC 바로가기 [Article Type] Article
Evidence of SARS-CoV2 Entry Protein ACE2 in the Human Nose and Olfactory Bulb인간의 코와 후각구에서 SARS-CoV2 진입 단백질 ACE2의 증거Article Published on 2020-01-012022-09-11 Journal: Cells, tissues, organs [Category] SARS, 치료기술, [키워드] ACE2 anatomical angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anosmia Basal cell basal cells Bulb caused Cell cell type cells Central nervous system clinical cough COVID-19 disease defined dissemination enzyme epithelial cell epithelial cells Evidence evidence of expressed expression expression pattern Fever Human immature Meningitis mild respiratory symptom mild respiratory symptoms nasal Nasal septum Neurological symptoms nose olfactory olfactory bulb Olfactory epithelium olfactory receptor olfactory receptor neuron olfactory receptor neurons organ pandemic paranasal Paranasal sinuses pathway positive Region respiratory respiratory epithelium respiratory symptoms Sagittal section SARS-CoV2 Serine severe symptom severe symptoms sustentacular cells Symptom tissue TMPRSS2 TMPRSS2 protein transmembrane serine protease transmembrane serine protease 2 vice Viral viral meningitis viral tropism [DOI] 10.1159/000513040 PMC 바로가기 [Article Type] Article
Antiviral activity of interleukin-11 as a response to porcine epidemic diarrhea virus infectionResearch Article Published on 2019-12-212022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] activating antagonized Anti-inflammatory Apoptosis caused Cell cytokine diarrhea ENhance epidemic diarrhea epithelial cell expression Factors IL-11 Infection inhibit inhibitor Interleukin-11 intestinal epithelium knockdown mRNA PEDV Phosphorylation physical positively correlated promoted protein level provide Replication signaling pathway significantly STAT3 suppress therapeutic Vero Cell VERO E6 cells viral infection viral infections virus virus infection [DOI] 10.1186/s13567-019-0729-9 PMC 바로가기 [Article Type] Research Article
Three Amino Acid Changes in Avian Coronavirus Spike Protein Allow Binding to Kidney TissueVirus-Cell Interactions Published on 2019-11-062022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] acid Amino acid Analysis Antiviral attachment protein bind binding binding site blocked bronchitis Cell change chimeric ciliated ciliated epithelial cell coronavirus Coronavirus infection dependent on determinant digestive tract disseminate ELISA enzyme-linked immunosorbent epithelial epithelial cell example facilitate IBV identify infect Infection Infectious Bronchitis Virus Interaction kidney kidneys knowledge lack Ligand M41 morbidity and mortality Mutation opposite organs preincubation Prevent prevented produced Protein RBD RBD proteins receptor Receptor-binding domain receptors replicate required respiratory tract sialic acid spike Spike protein strain the receptor-binding domain tissue tissues virus Virus-host interactions while [DOI] 10.1128/JVI.01363-19 PMC 바로가기 [Article Type] Virus-Cell Interactions