high mortality rate – Page 23 – Communicable Diseases Research

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

Research Article

Published on 2016-10-262022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] Accessory accessory protein activate Activation acute respiratory syndrome antagonistic Antiviral antiviral host response antiviral host responses antiviral response antiviral signaling binding cause cellular conditions coronavirus coronavirus protein curtail Defense described disease dsRNA eIF2α evade expressing expression high mortality rate Host Human IFN-α/β increasingly independent Infection innate response interfere life-threatening Ligand mechanisms MERS-CoV Middle East mild respiratory molecular mechanism motif p4a pathway Pathways phosphorylate PKR platform Prevent Protein protein 4a receptor reported reservoirs respiratory respiratory syndrome coronavirus response SARS-CoV sequestering severe respiratory infection Spread Stress stress granule suppress suppressed therapeutic intervention translation type I interferon viral dsRNA Viral protein virus virus infection viruses
[DOI] 10.1371/journal.ppat.1005982 PMC 바로가기 [Article Type] Research Article

Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians

Research Article

Published on 2016-07-122022-10-28
Journal: BMC Anesthesiology [Category] Coronavirus, MERS,

[키워드] Blood Care clinical trial convalescent convalescent plasma Convalescent plasma therapy coronavirus Critical care Critically ill determine diagnose domain feasibility high mortality rate ICU ICUs include indicated Infection involved ISARIC Kingdom Laboratory majority MERS-CoV MERS-CoV-infected patient Middle East Middle East respiratory syndrome coronavirus (MERS-CoV) MOST participated patients physician Physicians Placebo questionnaire Randomized controlled trial Randomized controlled trials RCT RCTs recovered patients reported Research respiratory respiratory pathogen responsible Result Saudi Arabia specific treatment supplementary material Treatment while
[DOI] 10.1186/s12871-016-0198-x PMC 바로가기 [Article Type] Research Article

Global research trends of Middle East respiratory syndrome coronavirus: a bibliometric analysis

Research Article

Published on 2016-06-072022-10-28
Journal: BMC Infectious Diseases [Category] Coronavirus,

Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients

Research

Published on 2016-05-072022-11-01
Journal: Critical Care [Category] Coronavirus, MERS,

[키워드] Admission age Analysis APACHE II applied bilateral pulmonary infiltrates Clinical data clinical feature coronavirus death Epidemic greater high mortality rate ICU independent risk factor Infection intensive care Invasive mechanical ventilation males mechanical ventilation MERS-CoV MERS-CoV infection Middle East morbidity and mortality observation period Older organ dysfunction outcome Patient patients patients died polymerase chain presentation reported Respiratory failure Respiratory samples respiratory syndrome coronavirus Result reverse transcription risk factor Saudi Arabia severity SOFA score supplementary material syndrome tachypnea therapy Vasopressor
[DOI] 10.1186/s13054-016-1303-8 PMC 바로가기 [Article Type] Research

High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling

Research Article

Published on 2016-02-262022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] applicability approach Betacoronavirus carried Cell coronavirus Coronaviruses Course culture cell deep sequencing determine digestion Efficiency epidemic diarrhea family Coronaviridae feature Frame frameshift Gene Expression Genome genomic high mortality rate Host host-virus interactions identify Infection investigated knowledge living cell mapped member MERS-CoV MHV MHV-A59 Middle East MONITOR mouse hepatitis virus mRNA mRNAs murine nucleotide Open reading frame open reading frames ORF ORFs Other pandemic Pathogens polyprotein positive pp1a Precision Profiling profiling analysis PROTECT purified regions Regulation Regulatory Replication ribosome RNA RNA sequencing RNA virus RNA viruses SARS-CoV sensitivity tissue transcript Transcription Transcriptome transcripts translated translation translational Triplet upstream viral mRNA Viral RNA virus was performed
[DOI] 10.1371/journal.ppat.1005473 PMC 바로가기 [Article Type] Research Article

Identification and pathogenicity of a variant porcine epidemic diarrhea virus field strain with reduced virulence

Short Report

Published on 2015-06-122022-10-28
Journal: Virology Journal [Category] Coronavirus,

Sequence and phylogenetic analysis of nucleocapsid genes of porcine epidemic diarrhea virus (PEDV) strains in China

Original Article

Published on 2013-02-072022-10-28
Journal: Archives of Virology [Category] Coronavirus, MERS,

Generation of human antibody fragments recognizing distinct epitopes of the nucleocapsid (N) SARS-CoV protein using a phage display approach

Research Article

Published on 2005-09-192022-10-28
Journal: BMC Infectious Diseases [Category] Coronavirus,