SARS-CoV-2 Infection in Pediatric Solid Organ Transplant Recipients: A Single Center Observation소아 고형 장기 이식 환자의 SARS-CoV-2 감염: 단일 센터 관찰Article Published on 2022-09-012022-09-12 Journal: Journal of pediatric gastroenterology and nutritio [Category] MERS, SARS, 진단, [키워드] acute infection acute respiratory syndrome antibody asymptomatic infection Blood bowel CD4 CD8 Cell center comparison coronavirus COVID-19 disease Frequency healthy identify IgG Immunosuppression in viral Infection interferon kidney transplant recipients lab liver medical record Mild Negative PCR negative test pandemic Patient patient death PCR PCR positive pediatric polymerase chain positive positive PCR positive test result proportion recipient recipients Record rejection SARS-CoV-2 SARS-COV-2 infection Solid solid organ transplant SOT Spike protein T-cell TEMRA tested Transplant was obtained [DOI] 10.1097/MPG.0000000000003548 PMC 바로가기 [Article Type] Article
Nano-multilamellar lipid vesicles promote the induction of SARS-CoV-2 immune responses by a protein-based vaccine formulationArticle Published on 2022-09-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 진단, [키워드] Activation acute respiratory syndrome addition antibody Antigen C57BL/6 CD4 Complete conditions coronavirus COVID-19 demonstrated Diseases displaying dose effective hallmark highlight IgG immune response immunization in vitro in vivo Lipid-based nanoparticles mice modulated MPLA Nano-multilamellar vesicles promote Protein RBD Receptor binding domain reduced required responses Safe SARS-CoV-2 serum spike subunit Subunit vaccine T-cell Response T-cell responses toxic effect Vaccine Vaccines Vesicle virus-neutralizing antibody [DOI] 10.1016/j.nano.2022.102595 PMC 바로가기
First wave of SARS-CoV-2 in Santiago Chile: Seroprevalence, asymptomatic infection and infection fatality rateArticle Published on 2022-09-012022-11-15 Journal: Epidemics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] adjusted affected age antibody antibody isotypes Asymptomatic asymptomatic infection asymptomatic patient attack rate calculated change Chile confirmed case contribute country COVID-19 cross-sectional detect Diseases Epidemic estimates fatality Fatality rate First wave Health health system heterogeneous highlight IgG IgM IgM and IgG indicate individual Infection Infection fatality rate infection prevalence information initial knowledge majority mortality rates MOST occurred pandemic produced provide reached Registered remained reported SARS-CoV-2 SARS-COV-2 infection seropositive Seroprevalence Serosurvey Seven Sex significant difference Spread Stress subpopulation susceptible symptomatic Threats were used [DOI] 10.1016/j.epidem.2022.100606 PMC 바로가기
Evidence of antibodies against SARS-CoV-2 in wild mustelids from Brittany (France)Article Published on 2022-09-012022-11-15 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody automated Brittany carried COVID-19 effective ELISA test epidemiological Epidemiosurveillance evidence of FIVE France French IgG Infection Martes martes Meles meles mustelids nucleocapsid qPCR Receptor binding domain S1 subunit S2 subunit SARS-CoV-2 serology seropositive Surveillance tested Viral protein western blot wildlife [DOI] 10.1111/tbed.14663 PMC 바로가기
Validation of laboratory developed serology assays for detection of IgG antibody to severe acute respiratory syndrome coronavirus 2 in the South African population남아프리카 인구에서 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 IgG 항체 검출을 위해 실험실에서 개발한 혈청학 분석의 검증Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African antibody approved assays authority Beta characterization circulating collected commercial immunoassay Concordance confirmation continent Control coronavirus country Coverage cross-reactive antibodies cut-off value Delta demonstrated described determine diagnostic differentiation ELISA enzyme IFA IgA IgG IgG antibody IgM immunosorbent Infection infection rate investigated Laboratory Laboratory developed lateral flow limit Local mammalian molecular pandemic Patient persistence Population populations positive positive predictive values Predictive predictive values product Quality assurance resource respiratory RT-PCR RT-PCR positive patient SARS-CoV-2 SARS-CoV-2 spike protein sensitivity Serological assay serological assays serology assay serology assays Serology assays. serum sample serum samples severe acute respiratory syndrome Coronavirus shown small sample size South South Africa specificity Spike protein Surveillance tested Vaccine validation variant [DOI] 10.1016/j.jviromet.2022.114571 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of the inactivated whole-virus adjuvanted COVID-19 vaccine VLA2001: A randomized, dose escalation, double-blind phase 1/2 clinical trial in healthy adults비활성화된 전체 바이러스 면역증강제 COVID-19 백신 VLA2001의 안전성 및 면역원성: 건강한 성인을 대상으로 한 무작위, 용량 증량, 이중 맹검 1/2상 임상 시험Clinical Trial Published on 2022-09-012022-09-12 Journal: The Journal of Infection [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Adjuvanted vaccine binding clinical development clinical trial conducted convalescent sera coronavirus COVID-19 COVID-19 vaccine CpG CpG 1018 dose Dose escalation dose-escalation double-blind evaluate expressing Frequency geometric mean titre GMT groups headache healthy High dose high-dose group highest dose IFN-γ IgG immunogenicity inactivated Inactivated vaccine injection Local medium N protein neutralizing antibody Open-label optimal dose outcome participant Phase 3 primary immunogenicity priming Randomized randomized trial RBD-binding IgG RBD-binding IgG antibody reactive recruited Registered reported S protein S protein binding IgG antibody Safety SARS-CoV-2 SARS-CoV-2 neutralizing antibody second vaccination severity significantly significantly higher statistically systemic reaction T-cell tested titre Tolerability vaccination Vaccine VLA2001 was selected Whole-virus vaccine. [DOI] 10.1016/j.jinf.2022.06.009 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 seroprevalence among healthcare personnel at a large health system in AtlantaArticle Published on 2022-09-012022-11-15 Journal: The American journal of the medical sciences [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Atlanta clinical care clinician community exposure conducted COVID-19 Cycle threshold value detectable estimate evaluated exposure to Factor female hcp health system healthcare healthcare personnel Healthcare system Healthcare workers hospital IgG IgG antibody Infection majority material offered patient with COVID-19 PCR PCR testing polymerase chain positive result Prevalence provided SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 RNA SARS-CoV-2 seroprevalence Seropositivity Serosurvey System unique [DOI] 10.1016/j.amjms.2022.04.009 PMC 바로가기
Vertical transmission and humoral immune response following maternal infection with SARS-CoV-2: a prospective multicenter cohort studyArticle Published on 2022-09-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% confidence interval anti-Nucleocapsid IgG anti-SARS-CoV-2 Anti-spike anti-Spike IgG antibodies antibody Blood conducted COVID-19 declined defined enrolled highest humoral immune response IgG IgM Infection Level mother multicenter cohort study Nasopharyngeal swab Neonatal Neonate Neonates nucleocapsid PCR PCR testing positive positive IgG antibody positive PCR result positive serology Post-infection Pregnancy pregnant women primary endpoint prospective cohort study RT-PCR SARS-CoV-2 SARS-COV-2 infection serology test seronegative seropositive spike IgG tested Transmission transmission of SARS-CoV-2 vertical transmission women [DOI] 10.1016/j.cmi.2022.04.001 PMC 바로가기
Safety and immunogenicity of a typhoid conjugate vaccine among children aged 9 months to 12 years in Malawi: a nested substudy of a double-blind, randomised controlled trial말라위에서 9개월에서 12세 사이의 어린이를 대상으로 한 장티푸스 접합 백신의 안전성 및 면역원성: 이중 맹검, 무작위 대조 시험의 중첩 하위 연구Clinical Trial Published on 2022-09-012022-09-12 Journal: The Lancet. Global health [Category] Fulltext, MERS, 살모넬라증, 임상, 진단, [키워드] 1:1 95% CI adverse event age analysed antibody assigned baseline children chronic health conditions clinical trial COVID-19 double-blind eight eligible eligible participant ELISA enrolled evaluated Evidence foundation geometric mean titre HIV IgG Immunosuppression intention-to-treat population intramuscularly Local Melinda Gate occurred outcomes participant Phase 3 provide public health randomised controlled trial Randomly reactogenicity receive recipient recipients Registered remained Safety screened titre Tolerability Trial typhoid fever vaccination Vaccine was collected [DOI] 10.1016/S2214-109X(22)00275-3 PMC 바로가기 [Article Type] Clinical Trial
Evaluating the immunogenicity of gold nanoparticles conjugated RBD with Freund’s adjuvant as a potential vaccine against SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 진단, [키워드] adjuvant Antigen assays BALB/c mice boost candidate candidate vaccine cell-mediated immune response cell-mediated response cloned COVID-19 COVID-19 pandemic COVID-19 vaccine cytokine E. coli ENhance evaluated Evaluating examined expressed Freund's adjuvant global pandemic gold Gold nanoparticle Gold nanoparticles Health Host humoral Humoral immunity Humoral response IFN-γ IgG IgM IgM and IgG immune immune response immune system Immunogenic proteins Incomplete injected interval long-term immune response marker material Nano-vaccines outcome pandemic purified RBD RBD antigen RBD protein repeated SARS-CoV-2 significantly higher stimulate structural protein the RBD protein treatment group Vaccine while [DOI] 10.1016/j.micpath.2022.105687 PMC 바로가기