Inhibition of Bruton tyrosine kinase in patients with severe COVID-19
Research Articles
[키워드] a BTK inhibitor
Acalabrutinib
activated
Activation
Administered
Analysis
baseline
blood monocyte
BTK
BTK inhibitor
C-reactive protein
Clinical improvement
Cohort
Controlled clinical trial
correlation
Course
COVID-19
discharged
elevated
evidenced
had no
healthy volunteers
Host
Hyperinflammatory
IL-6
immune response
Inflammation
inhibition
International
lymphopenia
Macrophage
macrophage activation
majority
measure
mechanical ventilation
normalized
off-label
on mechanical ventilation
over
Oxygen requirement
Oxygenation
Patient
patients
patients hospitalized
Randomized
reduced
regulate
selective
severe COVID-19
Signaling
significantly
supplemental oxygen
target
therapeutic strategy
Toxicity
Treatment
tyrosine
[DOI] 10.1126/sciimmunol.abd0110 PMC 바로가기 [Article Type] Research Articles
[DOI] 10.1126/sciimmunol.abd0110 PMC 바로가기 [Article Type] Research Articles