interferon – Page 23 – Communicable Diseases Research

The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies

숙주와 SARS-CoV-2의 전투: 선천 면역과 바이러스 회피 전략

Review

Published on 2022-05-042022-09-11
Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제,

Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen

CRISPR/Cas9 화면을 통한 SARS-CoV-2의 제한 요인으로 DAXX 식별

Article

Published on 2022-05-042022-09-11
Journal: Nature Communications [Category] COVID19(2023년), SARS, 유전자 메커니즘,

Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19

단일 세포 전사체는 노화와 함께 축적되고 COVID-19의 질병 중증도와 상관관계가 있는 고유한 기억 유사 NK 세포 하위 집합을 나타냅니다.

Article

Published on 2022-05-032022-09-11
Journal: Genome Medicine [Category] Coronavirus, 유전자 메커니즘, 치료제,

[키워드] accumulate accumulated age Ageing analysed Analysis antiviral responses applied CD52 Cell Characteristics COVID-19 COVID-19 disease COVID-19 patient dataset disease severity distribution dysfunction exhibited exhibiting flow cytometry function healthy control healthy donor healthy donors identify IFN-α immune system immunotherapies Immunotherapy Impact in vitro individual Infectious disease Infectious diseases influence innate lymphoid cell Innate lymphoid cells interferon lymphocyte Lymphocytes natural NK cell NK cells Peripheral blood peripheral blood samples phenotype positively correlated proinflammatory proportion scRNA-seq Sequencing Seurat single-cell single-cell level single-cell RNA-seq single-cell transcriptome single-cell transcriptomes Single-cell transcriptomics subpopulation subset Transcriptome type I interferon Type-I interferon. unique
[DOI] 10.1186/s13073-022-01049-3 PMC 바로가기 [Article Type] Article

Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms

감염 또는 신경학적 증상이 없는 대조군과 비교하여 COVID-19 감염 및 신경학적 증상이 있는 환자의 뇌척수액에서 바이러스 항원 및 염증성 바이오마커

Article

Published on 2022-05-022022-09-11
Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, 치료법,

[키워드] 95% CI age Antigen Biomarker capture Central nervous system cerebrospinal fluid clinical CNS component Concentration contribute Control control group controls correlated COVID COVID-19 COVID-19 infection COVID-19 severity cross-sectional cross-sectional study CSF Cytokines detectable disease severity Encephalopathy Evidence evidence of Gothenburg Health Organization healthy control highlight IL-10 IL-6 immune activation immune response immune responses immunoassay Infection Inflammatory Inflammatory biomarker inflammatory biomarkers Injury interferon interferon γ interleukin IQR male median microglobulin moderate Moderate COVID-19 Necrosis neurologic neuronal no differences nucleocapsid antigen Older outcome participant Participants Pathogenesis Patient patient groups platform Principal component principal component analysis Protein Sahlgrenska University Hospital SARS-COV-2 infection SARS-CoV-2 nucleocapsid scale severe COVID-19 severe disease significantly significantly higher Study protocol Swedish Symptom Symptoms test results Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α Viral Viral antigen viral invasion Viral RNA was performed with COVID-19 World Health Organization β2-microglobulin
[DOI] 10.1001/jamanetworkopen.2022.13253 PMC 바로가기 [Article Type] Article

The temporal course of T- and B-cell responses to vaccination with BNT162b2 and mRNA-1273

BNT162b2 및 mRNA-1273 백신 접종에 대한 T 세포 및 B 세포 반응의 시간적 경과

Article

Published on 2022-05-012022-09-11
Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration age ANAs antibody antinuclear antibodies Autoimmune response autoimmune responses B-cell response BNT162b2 coronavirus correlated Course COVID-19 detectable deviation dose doses elicit ELISA epitope Epitopes examined Factor Factors first dose first vaccination form healthcare professionals IFN-γ IgA IgG immune response immune responses immune system Immunity Immunosuppressed Immunosuppression individual Infection infection with SARS-CoV-2 influence interferon interferon-γ marker median median absolute deviation mRNA mRNA vaccine mRNA-1273 neutralization Neutralization assay participant Participants reaction recipient recipients recruited respiratory response responses against Result SARS-CoV-2 Screen second dose severe acute respiratory syndrome Coronavirus Sex significantly significantly increased T-cell Response the vaccine titre vaccination Vaccine vaccinees were measured
[DOI] 10.1016/j.cmi.2021.09.006 PMC 바로가기 [Article Type] Article

Human phospho-signaling networks of SARS-CoV-2 infection are rewired by population genetic variants

SARS-CoV-2 감염의 인간 phospho-signaling 네트워크는 인구 유전 변이에 의해 재배선됩니다

Article

Published on 2022-05-012022-09-11
Journal: Molecular Systems Biology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] alterations Amino acid amino acid substitution amino acid substitutions Analysis ARFGEF2 association Comorbidities contributing to COVID-19 COVID-19 pathology disrupt Evolution Factor Genetic genetic factors Genetic variant Genetic variation Glucose highlight homeostasis Hospitalization Host host defenses host responses Human human genetic variation identify immune responses in viral induce Infection innate immune responses Inter-individual variation interferon interferon response involved kinase leads life cycle MAPK Missense modulated motif motifs nucleotide pathology Pathways phosphorylation site phosphorylation sites protein-protein interaction RNA splicing SARS-CoV-2 SARS-COV-2 infection sequence Sequence motifs severe COVID-19 Signaling signaling pathway signaling pathways Single nucleotide variant SNV SNVs STARD13 TANK TBC1D4 TBK1 translational TRIM28 Viral viral life cycle Viral proteins with COVID-19
[DOI] 10.15252/msb.202110823 PMC 바로가기 [Article Type] Article

High T-cell response rate after COVID-19 vaccination in belimumab and rituximab recipients

벨리무맙 및 리툭시맙 수혜자에서 COVID-19 백신 접종 후 높은 T 세포 반응률

Article

Published on 2022-05-012022-09-11
Journal: Journal of autoimmunity [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

[키워드] absence All the patient all the patients analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Autoimmune diseases B cell B cells B-cell Belimumab caused circulating comparable completion complex Concentration consecutive patient Control COVID-19 COVID-19 vaccination COVID-19 vaccine detectable anti-SARS-CoV-2 antibodies detectable anti-SARS-CoV-2 antibody diagnostic evaluate evaluated exposure to healthcare personnel immune response immune responses immunogenicity indicate interferon Lupus material median mRNA vaccination mRNA vaccine mRNA vaccines neutralizing capacity Participants Patient patients patients treated positive pseudoviruses RBD receiving recipient recruited retention rituximab RTX SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 vaccination significantly lower strain systemic autoimmune disease Systemic autoimmune diseases T cell T-cell Response tested the antibodies the patient therapy Total treated Treatment vaccination Vaccine virus virus-specific cellular immunity
[DOI] 10.1016/j.jaut.2022.102827 PMC 바로가기 [Article Type] Article

SARS-CoV-2-specific antibody and T-cell responses 1 year after infection in people recovered from COVID-19: a longitudinal cohort study

COVID-19에서 회복된 사람들의 감염 1년 후 SARS-CoV-2-특이 항체 및 T-세포 반응: 종단 코호트 연구

Article

Published on 2022-05-012022-09-11
Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] Academy age analysed antibody Antibody Response antibody titres B.1.351 B.1.617.2 Beta Beta variant breadth caused center Chinese collected communicable disease Communicable Disease Diagnosis COVID-19 Critical cross-reactive cytokine cytokine profile D614G D614G variant delta variant Delta variants detect detectable discharged disease disease severity ELISA ELISPOT enrolled enzyme evaluated Follow-up Follow-up visit follow-up visits foundation humoral humoral and T-cell response ICS IFN-γ IFNγ IgA IgG antibodies IgG antibody IgM IL-2 immune immune response In-vitro individual individuals Infection initial interferon interferon γ interleukin interleukin-2 intracellular cytokine staining longitudinal cohort study magnitude Medical Research Council Medical Sciences memory memory immune response memory T-cell response memory T-cell responses microneutralisation assay natural Necrosis neutralising Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses neutralising antibody titre neutralising antibody titres no difference not disrupted participant Patient patients patients with moderate PBMC PBMCs plasma plasma sample plasma samples Protein Receptor-binding domain recovered patient recovered patients recruited reduce reduced reducing reduction Reinfection remained retained robustness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 strain SARS-CoV-2 viral SARS-CoV-2-specific T-cell response Science severe disease spike Spike protein subset symptom severity Symptoms T-cell Response T-cell responses tested the interferon the receptor-binding domain the SARS-CoV-2 titre TNFα tumour necrosis factor Tumour Necrosis Factor α variant variants variants of concern Viral proteins viral strain viral strains Wuhan Wuhan, China
[DOI] 10.1016/S2666-5247(22)00036-2 PMC 바로가기 [Article Type] Article

Clinical efficacy and safety of interferon-β-containing regimens in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

COVID-19 환자 치료에서 인터페론 베타 함유 요법의 임상 효능 및 안전성: 무작위 대조 시험의 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2022-05-012022-09-11
Journal: Expert review of anti-infective therapy [Category] COVID19(2023년), SARS, 임상, 치료제,

[키워드] 95% CI Admission adverse event all-cause mortality rate Antiviral treatment benefit clinical Clinical efficacy ClinicalTrials control group control groups Controlled controlled trials COVID-19 Efficacy Efficacy and safety help hospitalized patient hospitalized patients ICU ICU admission IFN-β inception increased risk increased survival intensive care intensive care unit interferon Interferon-β Meta-analysis Mortality mortality rate no significant difference Patient patients with COVID-19 Placebo Randomized Randomized controlled trial RCT RCTs reduce regimen regimens risk Safe SARS-CoV-2 searched serious AE significant difference study group study groups systematic review Treatment with COVID-19
[DOI] 10.1080/14787210.2022.2004118 PMC 바로가기 [Article Type] Meta-Analysis

ISGylation is increased in the peripheral blood mononuclear cells derived from symptomatic COVID-19 patients

Article

Published on 2022-05-012023-07-08
Journal: Experimental Biology and Medicine [Category] COVID19(2023년),

[키워드] COVID-19 Cytokine storm interferon Interferon-stimulated gene 15 ISGylation PBMCs
[DOI] 10.1177/15353702221075606 PMC 바로가기